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Examining the effects of BRG1 over-expression on Candida albicans strains growing as pseudohyphae
J. Mariscal, DP. Thomas, IA. Cleary
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
- MeSH
- Candida albicans * genetika MeSH
- fungální proteiny * genetika metabolismus MeSH
- hyfy MeSH
- regulace genové exprese u hub MeSH
- transkripční faktory genetika metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
The pathogen Candida albicans is pleiomorphic and grows in yeast and filamentous forms but the relationship between the regulation of different filamentous forms is unclear. BRG1 encodes a DNA binding protein which is an important regulator of morphology. Mutants lacking BRG1 grow as yeast under all conditions tested and over-expressing BRG1 drives hyphal growth even in the absence of inducing signals. A number of genetic mutants in repressors of filamentation form pseudohyphae under yeast conditions and some of these mutants can form hyphae under hypha-inducing conditions. This study examines the position of BRG1 in the regulatory networks that govern filamentation by examining the effect of over-expressing BRG1 in pseudohyphal mutants.
Citace poskytuje Crossref.org
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