Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Hypertension after the Menopause: What Can We Learn from Experimental Studies

J. Piťha, I. Vaněčková, J. Zicha

. 2023 ; 72 (Suppl 2) : S91-S112. [pub] 2023Jul31

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc23013873

Hypertension is the most prevalent cardiovascular disease of the adult population and is closely associated with serious cardiovascular events. The burden of hypertension with respect to vascular and other organ damage is greater in women. These sex differences are not fully understood. The unique feature in women is their transition to menopause accompanied by profound hormonal changes that affect the vasculature that are also associated with changes of blood pressure. Results from studies of hormone replacement therapy and its effects on the cardiovascular system are controversial, and the timing of treatment after menopause seems to be important. Therefore, revealing potential sex- and sex hormone-dependent pathophysiological mechanisms of hypertension in experimental studies could provide valuable information for better treatment of hypertension and vascular impairment, especially in postmenopausal women. The experimental rat models subjected to ovariectomy mimicking menopause could be useful tools for studying the mechanisms of blood pressure regulation after menopause and during subsequent therapy.

000      
00000naa a2200000 a 4500
001      
bmc23013873
003      
CZ-PrNML
005      
20231006100234.0
007      
ta
008      
230907s2023 xr d f 000 0|eng||
009      
AR
024    7_
$2 doi $a 10.33549/physiolres.935151
035    __
$a (PubMed)37565415
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Piťha, Jan, $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic $d 1964- $7 mzk2003187379 $u Second Medical Faculty, Motol Hospital, Prague, Czech Republic
245    10
$a Hypertension after the Menopause: What Can We Learn from Experimental Studies / $c J. Piťha, I. Vaněčková, J. Zicha
520    9_
$a Hypertension is the most prevalent cardiovascular disease of the adult population and is closely associated with serious cardiovascular events. The burden of hypertension with respect to vascular and other organ damage is greater in women. These sex differences are not fully understood. The unique feature in women is their transition to menopause accompanied by profound hormonal changes that affect the vasculature that are also associated with changes of blood pressure. Results from studies of hormone replacement therapy and its effects on the cardiovascular system are controversial, and the timing of treatment after menopause seems to be important. Therefore, revealing potential sex- and sex hormone-dependent pathophysiological mechanisms of hypertension in experimental studies could provide valuable information for better treatment of hypertension and vascular impairment, especially in postmenopausal women. The experimental rat models subjected to ovariectomy mimicking menopause could be useful tools for studying the mechanisms of blood pressure regulation after menopause and during subsequent therapy.
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a zvířata $7 D000818
650    12
$a hypertenze $7 D006973
650    _2
$a menopauza $x fyziologie $7 D008593
650    12
$a kardiovaskulární nemoci $x epidemiologie $7 D002318
650    _2
$a hormonální substituční terapie $7 D020249
650    _2
$a krevní tlak $x fyziologie $7 D001794
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vaněčková, Ivana, $d 1964- $7 xx0030586 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Zicha, Josef, $d 1950- $7 jk01152609 $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 72, Suppl 2 (2023), s. S91-S112
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37565415 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20230907 $b ABA008
991    __
$a 20231006100227 $b ABA008
999    __
$a ok $b bmc $g 1991300 $s 1200183
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 72 $c Suppl 2 $d S91-S112 $e 2023Jul31 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK198 $a Pubmed-20230907

Find record

Citation metrics

Archiving options