• Je něco špatně v tomto záznamu ?

Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light

C. Celiker, K. Weissova, KA. Cerna, J. Oppelt, B. Dorgau, FM. Gambin, J. Sebestikova, M. Lako, E. Sernagor, P. Liskova, T. Barta

. 2023 ; 26 (7) : 107237. [pub] 20230628

Status neindexováno Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23015676

Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and allows for adaptation to high levels of illumination, thereby enabling the rest of the visual system to remain responsive. It has been shown that retinal microRNA (miRNA) molecules play a key role in regulating these processes. However, despite extensive research using various model organisms, light-regulated miRNAs in human retinal cells remain unknown. Here, we aim to characterize these miRNAs. We generated light-responsive human retinal organoids that express miRNA families and clusters typically found in the retina. Using an in-house developed photostimulation device, we identified a subset of light-regulated miRNAs. Importantly, we found that these miRNAs are differentially regulated by distinct wavelengths of light and have a rapid turnover, highlighting the dynamic and adaptive nature of the human retina.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23015676
003      
CZ-PrNML
005      
20231020093600.0
007      
ta
008      
231010s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.isci.2023.107237 $2 doi
035    __
$a (PubMed)37485345
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Celiker, Canan $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
245    10
$a Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light / $c C. Celiker, K. Weissova, KA. Cerna, J. Oppelt, B. Dorgau, FM. Gambin, J. Sebestikova, M. Lako, E. Sernagor, P. Liskova, T. Barta
520    9_
$a Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and allows for adaptation to high levels of illumination, thereby enabling the rest of the visual system to remain responsive. It has been shown that retinal microRNA (miRNA) molecules play a key role in regulating these processes. However, despite extensive research using various model organisms, light-regulated miRNAs in human retinal cells remain unknown. Here, we aim to characterize these miRNAs. We generated light-responsive human retinal organoids that express miRNA families and clusters typically found in the retina. Using an in-house developed photostimulation device, we identified a subset of light-regulated miRNAs. Importantly, we found that these miRNAs are differentially regulated by distinct wavelengths of light and have a rapid turnover, highlighting the dynamic and adaptive nature of the human retina.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Weissova, Kamila $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Brno, Czech Republic
700    1_
$a Cerna, Katerina Amruz $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Oppelt, Jan $u Department of Pathology and Laboratory Medicine, Division of Neuropathology, Philadelphia, PA, USA
700    1_
$a Dorgau, Birthe $u Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
700    1_
$a Gambin, Francisco Molina $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Sebestikova, Jana $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Lako, Majlinda $u Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
700    1_
$a Sernagor, Evelyne $u Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
700    1_
$a Liskova, Petra $u Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Barta, Tomas $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
773    0_
$w MED00197302 $t iScience $x 2589-0042 $g Roč. 26, č. 7 (2023), s. 107237
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37485345 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20231010 $b ABA008
991    __
$a 20231020093553 $b ABA008
999    __
$a ok $b bmc $g 1997220 $s 1202038
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 26 $c 7 $d 107237 $e 20230628 $i 2589-0042 $m iScience $n iScience $x MED00197302
LZP    __
$a Pubmed-20231010

Najít záznam

Citační ukazatele

Možnosti archivace