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Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light

C. Celiker, K. Weissova, KA. Cerna, J. Oppelt, B. Dorgau, FM. Gambin, J. Sebestikova, M. Lako, E. Sernagor, P. Liskova, T. Barta

. 2023 ; 26 (7) : 107237. [pub] 20230628

Status neindexováno Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23015676

Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and allows for adaptation to high levels of illumination, thereby enabling the rest of the visual system to remain responsive. It has been shown that retinal microRNA (miRNA) molecules play a key role in regulating these processes. However, despite extensive research using various model organisms, light-regulated miRNAs in human retinal cells remain unknown. Here, we aim to characterize these miRNAs. We generated light-responsive human retinal organoids that express miRNA families and clusters typically found in the retina. Using an in-house developed photostimulation device, we identified a subset of light-regulated miRNAs. Importantly, we found that these miRNAs are differentially regulated by distinct wavelengths of light and have a rapid turnover, highlighting the dynamic and adaptive nature of the human retina.

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$a Cells in the human retina must rapidly adapt to constantly changing visual stimuli. This fast adaptation to varying levels and wavelengths of light helps to regulate circadian rhythms and allows for adaptation to high levels of illumination, thereby enabling the rest of the visual system to remain responsive. It has been shown that retinal microRNA (miRNA) molecules play a key role in regulating these processes. However, despite extensive research using various model organisms, light-regulated miRNAs in human retinal cells remain unknown. Here, we aim to characterize these miRNAs. We generated light-responsive human retinal organoids that express miRNA families and clusters typically found in the retina. Using an in-house developed photostimulation device, we identified a subset of light-regulated miRNAs. Importantly, we found that these miRNAs are differentially regulated by distinct wavelengths of light and have a rapid turnover, highlighting the dynamic and adaptive nature of the human retina.
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$a Weissova, Kamila $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Brno, Czech Republic
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$a Cerna, Katerina Amruz $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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$a Oppelt, Jan $u Department of Pathology and Laboratory Medicine, Division of Neuropathology, Philadelphia, PA, USA
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$a Dorgau, Birthe $u Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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$a Gambin, Francisco Molina $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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$a Sebestikova, Jana $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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$a Lako, Majlinda $u Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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$a Sernagor, Evelyne $u Biosciences Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
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$a Liskova, Petra $u Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic
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$a Barta, Tomas $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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