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A-agents, misleadingly known as "Novichoks": a narrative review
J. Opravil, J. Pejchal, V. Finger, J. Korabecny, T. Rozsypal, M. Hrabinova, L. Muckova, V. Hepnarova, J. Konecny, O. Soukup, D. Jun
Language English Country Germany
Document type Journal Article, Review
Grant support
DZRO-FVZ22-ZHN II
Ministry of Defence of the Czech Republic
DZRO-UOPZHN22-PROTECT II
Ministry of Defence of the Czech Republic
22-12859S
Czech Science Foundation
LUAUS23275
Ministry of Education, Youth, and Sports of the Czech Republic
SV/FVZ202302
Ministry of Education, Youth, and Sports of the Czech Republic
NLK
ProQuest Central
from 2002-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2002-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2002-01-01 to 1 year ago
- MeSH
- Drug Contamination * MeSH
- Nerve Agents * toxicity MeSH
- Organophosphorus Compounds MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
"Novichok" refers to a new group of nerve agents called the A-series agents. Their existence came to light in 2018 after incidents in the UK and again in 2020 in Russia. They are unique organophosphorus-based compounds developed during the Cold War in a program called Foliant in the USSR. This review is based on original chemical entities from Mirzayanov's memoirs published in 2008. Due to classified research, a considerable debate arose about their structures, and hence, various structural moieties were speculated. For this reason, the scientific literature is highly incomplete and, in some cases, contradictory. This review critically assesses the information published to date on this class of compounds. The scope of this work is to summarize all the available and relevant information, including the physicochemical properties, chemical synthesis, mechanism of action, toxicity, pharmacokinetics, and medical countermeasures used to date. The environmental stability of A-series agents, the lack of environmentally safe decontamination, their high toxicity, and the scarcity of information on post-contamination treatment pose a challenge for managing possible incidents.
References provided by Crossref.org
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