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HLA in isolated REM sleep behavior disorder and Lewy body dementia
E. Yu, L. Krohn, JA. Ruskey, F. Asayesh, D. Spiegelman, Z. Shah, R. Chia, I. Arnulf, MTM. Hu, JY. Montplaisir, JF. Gagnon, A. Desautels, Y. Dauvilliers, GL. Gigli, M. Valente, F. Janes, A. Bernardini, B. Högl, A. Stefani, A. Ibrahim, A....
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
ZIA NS003154
Intramural NIH HHS - United States
NLK
Directory of Open Access Journals
from 2014
Free Medical Journals
from 2014 to 2 years ago
PubMed Central
from 2014
Europe PubMed Central
from 2014
ProQuest Central
from 2014-01-01
Open Access Digital Library
from 2014-01-01
Open Access Digital Library
from 2014-01-01
Health & Medicine (ProQuest)
from 2014-01-01
Psychology Database (ProQuest)
from 2014-01-01
Wiley-Blackwell Open Access Titles
from 2014
PubMed
37401389
DOI
10.1002/acn3.51841
Knihovny.cz E-resources
- MeSH
- Lewy Body Disease * genetics MeSH
- HLA Antigens MeSH
- HLA-DRB1 Chains genetics MeSH
- Humans MeSH
- REM Sleep Behavior Disorder * genetics complications MeSH
- Synucleinopathies * genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
Clinical Neurology Unit Department of Neurosciences University Hospital of Udine Udine Italy
Department of Human Genetics McGill University Montréal Québec Canada
Department of Medicine University of Udine Udine Italy
Department of Neurological Sciences Università Vita Salute San Raffaele Milan Italy
Department of Neurology and Neurosurgery McGill University Montréal Québec Canada
Department of Neurology Johns Hopkins University Medical Center Baltimore Maryland USA
Department of Neurology Mayo Clinic Rochester Minnesota USA
Department of Neurology Philipps University Marburg Germany
Department of Neurology St Dimpna Regional Hospital Geel Belgium
Department of Neurology University Hospital Antwerp Edegem Antwerp Belgium
Department of Neurosciences Université de Montréal Montréal Québec Canada
Department of Neurosurgery University Medical Centre Göttingen Göttingen Germany
Department of Psychiatry Université de Montréal Montréal Québec Canada
Department of Psychology Université du Québec à Montréal Montréal Québec Canada
Division of Neurology Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK
EuroMov Digital Health in Motion University of Montpellier IMT Mines Ales Montpellier France
IRCCS Institute of Neurological Sciences of Bologna Bologna Italy
Laboratory for Sleep Disorders St Dimpna Regional Hospital Geel Belgium
Neuromuscular Diseases Research Section National Institute on Aging Bethesda Maryland USA
Oxford Parkinson's Disease Centre University of Oxford Oxford UK
Paracelsus Elena Klinik Kassel Germany
Sleep and Neurology Unit Beau Soleil Clinic Montpellier France
Sleep disorder Unit Carémeau Hospital University Hospital of Nîmes Nîmes France
Sleep Disorders Clinic Department of Neurology Medical University of Innsbruck Innsbruck Austria
References provided by Crossref.org
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