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Autor
Abril, Beatriz 1 Antelmi, Elena 1 Arnulf, Isabelle 1 Asayesh, Farnaz 1 Bernardini, Andrea 1 Boeve, Bradley F 1 Chia, Ruth 1 Cochen De Cock, Valérie 1 Dauvilliers, Yves 1 Desautels, Alex 1 Dijkstra, Femke 1 Dusek, Petr 1 Ferini-Strambi, Luigi 1 Figorilli, Michela 1 Gagnon, Jean-François 1 Gan-Or, Ziv 1 Gigli, Gian Luigi 1 Heidbreder, Anna 1 Hu, Michele T M 1 Högl, Birgit 1
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Pracoviště
Center for Advanced Research in Sleep... 1 Clinical Neurology Unit Department of... 1 Department for Sleep Medicine and Neu... 1 Department of Biomedical Metabolic an... 1 Department of Human Genetics McGill U... 1 Department of Medical Sciences and Pu... 1 Department of Medicine University of ... 1 Department of Neurological Sciences U... 1 Department of Neurology Johns Hopkins... 1 Department of Neurology Mayo Clinic R... 1 Department of Neurology Philipps Univ... 1 Department of Neurology St Dimpna Reg... 1 Department of Neurology University Ho... 1 Department of Neurology and Centre of... 1 Department of Neurology and Neurosurg... 1 Department of Neurosciences Universit... 1 Department of Neurosurgery University... 1 Department of Psychiatry Université d... 1 Department of Psychology Université d... 1 Division of Neurology Nuffield Depart... 1
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Autor
Abril, Beatriz 1 Antelmi, Elena 1 Arnulf, Isabelle 1 Asayesh, Farnaz 1 Bernardini, Andrea 1 Boeve, Bradley F 1 Chia, Ruth 1 Cochen De Cock, Valérie 1 Dauvilliers, Yves 1 Desautels, Alex 1 Dijkstra, Femke 1 Dusek, Petr 1 Ferini-Strambi, Luigi 1 Figorilli, Michela 1 Gagnon, Jean-François 1 Gan-Or, Ziv 1 Gigli, Gian Luigi 1 Heidbreder, Anna 1 Hu, Michele T M 1 Högl, Birgit 1
- Organizace
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Pracoviště
Center for Advanced Research in Sleep... 1 Clinical Neurology Unit Department of... 1 Department for Sleep Medicine and Neu... 1 Department of Biomedical Metabolic an... 1 Department of Human Genetics McGill U... 1 Department of Medical Sciences and Pu... 1 Department of Medicine University of ... 1 Department of Neurological Sciences U... 1 Department of Neurology Johns Hopkins... 1 Department of Neurology Mayo Clinic R... 1 Department of Neurology Philipps Univ... 1 Department of Neurology St Dimpna Reg... 1 Department of Neurology University Ho... 1 Department of Neurology and Centre of... 1 Department of Neurology and Neurosurg... 1 Department of Neurosciences Universit... 1 Department of Neurosurgery University... 1 Department of Psychiatry Université d... 1 Department of Psychology Université d... 1 Division of Neurology Nuffield Depart... 1
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- Yu, Eric
- Krohn, Lynne
- Ruskey, Jennifer A
- Asayesh, Farnaz
- Spiegelman, Dan
- Shah, Zalak
- Chia, Ruth
- Arnulf, Isabelle
- Hu, Michele T M
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Montplaisir, Jacques Y
Autor Montplaisir, Jacques Y Center for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada
PubMed Central od 2014
Europe PubMed Central od 2014
ProQuest Central od 2014-01-01
Open Access Digital Library od 2014-01-01
Open Access Digital Library od 2014-01-01
Health & Medicine (ProQuest) od 2014-01-01
Psychology Database (ProQuest) od 2014-01-01
Wiley-Blackwell Open Access Titles od 2014
PubMed
37401389
DOI
10.1002/acn3.51841
Knihovny.cz E-zdroje
Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
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