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Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
M. Čarna, IG. Onyango, S. Katina, D. Holub, JS. Novotny, M. Nezvedova, D. Jha, Z. Nedelska, V. Lacovich, TV. Vyvere, R. Houbrechts, K. Garcia-Mansfield, R. Sharma, V. David-Dirgo, M. Vyhnalek, K. Texlova, H. Chaves, N. Bakkar, L. Pertierra, M....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
U01 U01AG061357
NIA NIH HHS - United States
U01 AG061357
NIA NIH HHS - United States
P30 AGO62429
NIH HHS - United States
P30 CA033572
NCI NIH HHS - United States
6980382
NIA NIH HHS - United States
P30 AG066530
NIA NIH HHS - United States
LX22NPO5107
NIA NIH HHS - United States
PubMed
36825691
DOI
10.1002/alz.12970
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc * patologie MeSH
- lidé MeSH
- plexus chorioideus metabolismus patologie MeSH
- proteomika MeSH
- stárnutí MeSH
- zánět MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD. HIGHLIGHTS: Cerebrospinal fluid changes associated with aging are perturbed in Alzheimer's disease Paradoxically, in Alzheimer's disease, the choroid plexus exhibits increased cytokine levels without evidence of inflammatory activation or infiltrates In Alzheimer's disease, increased choroid plexus volumes correlate with age and cognitive performance.
Center for Neurodegenerative Disease Emory University School of Medicine Atlanta Georgia USA
Center for Neurologic Study La Jolla California USA
Department of Cellular Pathology Imperial College Healthcare NHS Trust London UK
Department of Neurobiology Barrow Neurological Institute Phoenix Arizona USA
Department of Neurosciences University of California San Diego La Jolla California USA
Departments of Bioachemistry and Neurology Emory University School of Medicine Atlanta Georgia USA
Division of Neurology University Medical Centre Ljubljana Slovenia
Goizueta Alzheimer's Disease Research Center Emory University Atlanta Georgia USA
Imperial College London Faculty of Medicine London UK
Institute of Hematology and Blood Transfusion Prague Czech Republic
Institute of Mathematics and Statistics Masaryk University Brno Czech Republic
International Clinical Research Centre St Anne's University Hospital Brno Czech Republic
RECETOX Centre Faculty of Sciences Masaryk University Brno Czech Republic
Translational Aging and Neuroscience Program Mayo Clinic Rochester Minnesota USA
Citace poskytuje Crossref.org
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