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Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
MN. Kjær, TS. Meyhoff, P. Sivapalan, A. Granholm, PB. Hjortrup, MB. Madsen, MH. Møller, I. Egerod, J. Wetterslev, T. Lange, M. Cronhjort, JH. Laake, SM. Jakob, M. Nalos, M. Ostermann, D. Gould, M. Cecconi, MLNG. Malbrain, C. Ahlstedt, LB. Kiel,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, komentáře
Grantová podpora
NNF17OC0028608.
AgNovos Healthcare
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- jednotky intenzivní péče MeSH
- kvalita života MeSH
- lidé MeSH
- péče o pacienty v kritickém stavu MeSH
- přežívající MeSH
- septický šok * terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- komentáře MeSH
PURPOSE: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. METHODS: We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. RESULTS: Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) - 4.8 to 7.8]. Mean differences were 0.00 (99% CI - 0.06 to 0.05) for EQ-5D-5L index values, - 0.65 for EQ VAS (- 5.40 to 4.08), and - 0.14 for Mini MoCA (- 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. CONCLUSIONS: Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.
1st Department of Anaesthesiology and Intensive Therapy Medical University Lublin Lublin Poland
Anaesthesia and Intensive Care Medicine IRCCS Humanitas Research Hospital Rozzano Milan Italy
Anesthesia and Intensive Care Unit Azienda Ospedaliero Universitaria Delle Marche Ancona Italy
Anesthesia and Intensive Care Unit Humanitas Research Hospital Castellanza Italy
Clinical Trial Unit Intensive Care National Audit and Research Centre London UK
Collaboration for Research in Intensive Care Copenhagen Denmark
Copenhagen Academy for Medical Education and Simulation Rigshospitalet Copenhagen Denmark
Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark
Department of Anaesthesia and Intensive Care Capio St Görans Hospital Stockholm Sweden
Department of Anaesthesia and Intensive Care Herning Hospital Herning Denmark
Department of Anaesthesia and Intensive Care Holbæk Hospital Holbæk Denmark
Department of Anaesthesia and Intensive Care Humanitas Gavazzeni Hospital Bergamo Bergamo Italy
Department of Anaesthesia and Intensive Care Randers Hospital Randers Denmark
Department of Anaesthesia and Intensive Care Viborg Hospital Viborg Denmark
Department of Anaesthesia and Intensive Care Zealand University Hospital Køge Denmark
Department of Anaesthesia and Intensive Care Zealand University Hospital Roskilde Denmark
Department of Anesthesia and Intensive Care Medicine Hospital Østfold Kalnes Grålum Norway
Department of Anesthesia and Intensive Care Oslo University Hospital Ullevål Oslo Norway
Department of Biomedical Sciences and Public Health Università Politecnica Delle Marche Ancona Italy
Department of Biomedical Sciences Humanitas University Pieve Emanuele Milan Italy
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Emergency Medicine Capio St Görans Hospital Stockholm Sweden
Department of Intensive Care Guy's and St Thomas' Hospital London UK
Department of Intensive Care Hospital Innland Hamar Hamar Norway
Department of Intensive Care Medicine Stavanger University Hospital Stavanger Norway
Department of Intensive Care Medicine University Hospital Bern University of Bern Bern Switzerland
Department of Intensive Care Medicine University Hospital Brussels Jette Belgium
Department of Perioperative Medicine and Intensive Care Karolinska University Hospital Solna Sweden
Faculty of Medicine and Pharmacy Vrije Universiteit Brussel Brussels Belgium
Institute of Clinical Medicine University of Oslo Oslo Norway
Intensive Care Unit Basel University Hospital Basel Switzerland
Section of Biostatistics Department of Public Health University of Copenhagen Copenhagen Denmark
Citace poskytuje Crossref.org
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- $a Kjær, Maj-Brit Nørregaard $u Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. maj-brit.noerregaard.kjaer@regionh.dk $u Collaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark. maj-brit.noerregaard.kjaer@regionh.dk $1 https://orcid.org/0000000265360504
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- $a Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock / $c MN. Kjær, TS. Meyhoff, P. Sivapalan, A. Granholm, PB. Hjortrup, MB. Madsen, MH. Møller, I. Egerod, J. Wetterslev, T. Lange, M. Cronhjort, JH. Laake, SM. Jakob, M. Nalos, M. Ostermann, D. Gould, M. Cecconi, MLNG. Malbrain, C. Ahlstedt, LB. Kiel, MH. Bestle, L. Nebrich, T. Hildebrandt, L. Russell, M. Vang, ML. Rasmussen, C. Sølling, AC. Brøchner, M. Krag, C. Pfortmueller, M. Kriz, M. Siegemund, G. Albano, SR. Aagaard, H. Bundgaard, V. Crone, S. Wichmann, B. Johnstad, YK. Martin, P. Seidel, J. Mårtensson, J. Hollenberg, M. Wistrand, A. Donati, E. Barbara, T. Karvunidis, A. Hollinger, A. Carsetti, N. Lumlertgul, E. Joelsson-Alm, N. Lambiris, TN. Aslam, FF. Friberg, GK. Vesterlund, CB. Mortensen, SR. Vestergaard, SF. Caspersen, DB. Jensen, M. Borup, BS. Rasmussen, A. Perner
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