• Something wrong with this record ?

Dietary environmental factors shape the immune defense against Cryptosporidium infection

MR. Maradana, NB. Marzook, OE. Diaz, T. Mkandawire, NL. Diny, Y. Li, A. Liebert, K. Shah, M. Tolaini, M. Kváč, B. Stockinger, A. Sateriale

. 2023 ; 31 (12) : 2038-2050.e4. [pub] 20231204

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24000248

Cryptosporidium is a leading cause of diarrheal-related deaths in children, especially in resource-poor settings. It also targets the immunocompromised, chronically infecting people living with HIV and primary immunodeficiencies. There is no vaccine or effective treatment. Although it is known from human cases and animal models that CD4+ T cells play a role in curbing Cryptosporidium, the role of CD8+ T cells remains to be defined. Using a Cryptosporidium tyzzeri mouse model, we show that gut-resident CD8+ intraepithelial lymphocytes (IELs) confer resistance to parasite growth. CD8+ IELs express and depend on the ligand-dependent transcription factor aryl hydrocarbon receptor (AHR). AHR deficiency reduces CD8+ IELs, decreases their cytotoxicity, and worsens infection. Transfer of CD8+ IELs rescues severely immunodeficient mice from death following Cryptosporidium challenge. Finally, dietary supplementation of the AHR pro-ligand indole-3-carbinol in newborn mice promotes resistance to infection. Therefore, common dietary metabolites augment the host immune response to cryptosporidiosis, protecting against disease.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24000248
003      
CZ-PrNML
005      
20240213093032.0
007      
ta
008      
240109s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.chom.2023.11.008 $2 doi
035    __
$a (PubMed)38052207
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Maradana, Muralidhara Rao $u AhR Immunity Lab, The Francis Crick Institute, London, UK
245    10
$a Dietary environmental factors shape the immune defense against Cryptosporidium infection / $c MR. Maradana, NB. Marzook, OE. Diaz, T. Mkandawire, NL. Diny, Y. Li, A. Liebert, K. Shah, M. Tolaini, M. Kváč, B. Stockinger, A. Sateriale
520    9_
$a Cryptosporidium is a leading cause of diarrheal-related deaths in children, especially in resource-poor settings. It also targets the immunocompromised, chronically infecting people living with HIV and primary immunodeficiencies. There is no vaccine or effective treatment. Although it is known from human cases and animal models that CD4+ T cells play a role in curbing Cryptosporidium, the role of CD8+ T cells remains to be defined. Using a Cryptosporidium tyzzeri mouse model, we show that gut-resident CD8+ intraepithelial lymphocytes (IELs) confer resistance to parasite growth. CD8+ IELs express and depend on the ligand-dependent transcription factor aryl hydrocarbon receptor (AHR). AHR deficiency reduces CD8+ IELs, decreases their cytotoxicity, and worsens infection. Transfer of CD8+ IELs rescues severely immunodeficient mice from death following Cryptosporidium challenge. Finally, dietary supplementation of the AHR pro-ligand indole-3-carbinol in newborn mice promotes resistance to infection. Therefore, common dietary metabolites augment the host immune response to cryptosporidiosis, protecting against disease.
650    _2
$a dítě $7 D002648
650    _2
$a lidé $7 D006801
650    _2
$a myši $7 D051379
650    _2
$a zvířata $7 D000818
650    12
$a kryptosporidióza $x parazitologie $7 D003457
650    _2
$a CD8-pozitivní T-lymfocyty $7 D018414
650    12
$a Cryptosporidium $7 D003458
650    _2
$a ligandy $7 D008024
650    _2
$a dieta $7 D004032
655    _2
$a časopisecké články $7 D016428
700    1_
$a Marzook, N Bishara $u Cryptosporidiosis Lab, The Francis Crick Institute, London, UK
700    1_
$a Diaz, Oscar E $u AhR Immunity Lab, The Francis Crick Institute, London, UK
700    1_
$a Mkandawire, Tapoka $u Cryptosporidiosis Lab, The Francis Crick Institute, London, UK
700    1_
$a Diny, Nicola Laura $u AhR Immunity Lab, The Francis Crick Institute, London, UK
700    1_
$a Li, Ying $u AhR Immunity Lab, The Francis Crick Institute, London, UK
700    1_
$a Liebert, Anke $u AhR Immunity Lab, The Francis Crick Institute, London, UK
700    1_
$a Shah, Kathleen $u AhR Immunity Lab, The Francis Crick Institute, London, UK
700    1_
$a Tolaini, Mauro $u AhR Immunity Lab, The Francis Crick Institute, London, UK
700    1_
$a Kváč, Martin $u Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic
700    1_
$a Stockinger, Brigitta $u AhR Immunity Lab, The Francis Crick Institute, London, UK. Electronic address: brigitta.stockinger@crick.ac.uk
700    1_
$a Sateriale, Adam $u Cryptosporidiosis Lab, The Francis Crick Institute, London, UK. Electronic address: adam.sateriale@crick.ac.uk
773    0_
$w MED00173236 $t Cell host & microbe $x 1934-6069 $g Roč. 31, č. 12 (2023), s. 2038-2050.e4
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38052207 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240109 $b ABA008
991    __
$a 20240213093029 $b ABA008
999    __
$a ok $b bmc $g 2049116 $s 1209942
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 31 $c 12 $d 2038-2050.e4 $e 20231204 $i 1934-6069 $m Cell host & microbe $n Cell Host Microbe $x MED00173236
LZP    __
$a Pubmed-20240109

Find record

Citation metrics

Archiving options