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Inter-placental variability is not a major factor affecting the healing efficiency of amniotic membrane when used for treating chronic non-healing wounds

V. Horvath, A. Svobodova, JV. Cabral, R. Fiala, J. Burkert, P. Stadler, J. Lindner, J. Bednar, M. Zemlickova, K. Jirsova

. 2023 ; 24 (4) : 779-788. [pub] 20230525

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24000552

Grant support
NV18-08-00106 Ministerstvo Zdravotnictví Ceské Republiky
BBMRI_CZ LM2018125 Ministerstvo Školství, Mládeže a Tělovýchovy
Cooperacio Univerzita Karlova v Praze
Medical Diagnostics Univerzita Karlova v Praze
Basic Medical Sciences Univerzita Karlova v Praze

E-resources Online Full text

NLK ProQuest Central from 2000-01-01 to 1 year ago
Medline Complete (EBSCOhost) from 2011-02-01 to 1 year ago
Nursing & Allied Health Database (ProQuest) from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest) from 2000-01-01 to 1 year ago

Links

PubMed 37227562
DOI 10.1007/s10561-023-10096-y
Knihovny.cz E-resources

This study aimed to evaluate the efficacy of cryopreserved amniotic membrane (AM) grafts in chronic wound healing, including the mean percentage of wound closure per one AM application, and to determine whether the healing efficiency differs between AM grafts obtained from different placentas. A retrospective study analyzing inter-placental differences in healing capacity and mean wound closure after the application of 96 AM grafts prepared from nine placentas. Only the placentas from which the AM grafts were applied to patients suffering from long-lasting non-healing wounds successfully healed by AM treatment were included. The data from the rapidly progressing wound-closure phase (p-phase) were analyzed. The mean efficiency for each placenta, expressed as an average of wound area reduction (%) seven days after the AM application (baseline, 100%), was calculated from at least 10 applications. No statistical difference between the nine placentas' efficiency was found in the progressive phase of wound healing. The 7-day average wound reduction in particular placentas varied from 5.70 to 20.99% (median from 1.07 to 17.75) of the baseline. The mean percentage of wound surface reduction of all analyzed defects one week after the application of cryopreserved AM graft was 12.17 ± 20.12% (average ± SD). No significant difference in healing capacity was observed between the nine placentas. The data suggest that if there are intra- and inter-placental differences in AM sheets' healing efficacy, they are overridden by the actual health status of the subject or even the status of its individual wounds.

References provided by Crossref.org

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