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International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World
MI. Rodriguez-Davalos, F. Lopez-Verdugo, M. Kasahara, P. Muiesan, MS. Reddy, A. Flores-Huidobro Martinez, Q. Xia, JC. Hong, CU. Niemann, J. Seda-Neto, TA. Miloh, NJ. Yi, GV. Mazariegos, VL. Ng, CO. Esquivel, J. Lerut, M. Rela, Pediatric Liver...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- dítě MeSH
- lidé MeSH
- nemoci jater * MeSH
- sčítání lidu MeSH
- smrt MeSH
- transplantace jater * škodlivé účinky MeSH
- žijící dárci MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions. METHODS: A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita. RESULTS: One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries. CONCLUSIONS: This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.
Department of Abdominal Transplantation Stanford University Medical Center Palo Alto CA
Department of Hepatology and Liver Transplantation Hospital Sirio Libanes Sao Paulo Brazil
Department of Surgery Seoul National University College of Medicine Seoul Republic of Korea
Department of Surgery University of California San Francisco San Francisco CA
Division of Transplant Surgery Department of Surgery Medical College of Wisconsin Milwaukee WI
Hillman Center for Pediatric Transplantation UPMC Children's Hospital of Pittsburgh Pittsburgh PA
Institute for Experimental and Clinical Research Université Catholique Louvain Brussels Belgium
Institute of Liver Studies King's College Hospital London United Kingdom
Liver Unit Birmingham Children's Hospital NHS Foundation Trust Birmingham United Kingdom
Miami Transplant Institute University of Miami Miami FL
Organ Transplantation Center National Center for Child Health and Development Tokyo Japan
School of Medicine Tecnologico de Monterrey Mexico City Mexico
Citace poskytuje Crossref.org
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- $a Rodriguez-Davalos, Manuel I $u Liver Transplant Unit, Intermountain Primary Children's Hospital and the Center for Global Surgery, University of Utah, Salt Lake City, UT
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- $a BACKGROUND: Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions. METHODS: A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita. RESULTS: One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries. CONCLUSIONS: This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.
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