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International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World

MI. Rodriguez-Davalos, F. Lopez-Verdugo, M. Kasahara, P. Muiesan, MS. Reddy, A. Flores-Huidobro Martinez, Q. Xia, JC. Hong, CU. Niemann, J. Seda-Neto, TA. Miloh, NJ. Yi, GV. Mazariegos, VL. Ng, CO. Esquivel, J. Lerut, M. Rela, Pediatric Liver...

. 2023 ; 107 (10) : 2087-2097. [pub] 20230925

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24001133

BACKGROUND: Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions. METHODS: A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita. RESULTS: One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries. CONCLUSIONS: This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.

Department of Abdominal Transplantation Stanford University Medical Center Palo Alto CA

Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco CA

Department of Hepatology and Liver Transplantation Hospital Sirio Libanes Sao Paulo Brazil

Department of Liver Surgery and Liver Transplantation Renji Hospital Shanghai People's Republic of China

Department of Surgery Seoul National University College of Medicine Seoul Republic of Korea

Department of Surgery University of California San Francisco San Francisco CA

Division of Pediatric Gastroenterology Hepatology and Nutrition and Transplant and Regenerative Medicine Center The Hospital for Sick Children University of Toronto Toronto Canada

Division of Transplant Surgery Department of Surgery Medical College of Wisconsin Milwaukee WI

Hillman Center for Pediatric Transplantation UPMC Children's Hospital of Pittsburgh Pittsburgh PA

Institute for Experimental and Clinical Research Université Catholique Louvain Brussels Belgium

Institute of Liver Studies King's College Hospital London United Kingdom

Liver Transplant Unit Intermountain Primary Children's Hospital and the Center for Global Surgery University of Utah Salt Lake City UT

Liver Unit Birmingham Children's Hospital NHS Foundation Trust Birmingham United Kingdom

Miami Transplant Institute University of Miami Miami FL

Organ Transplantation Center National Center for Child Health and Development Tokyo Japan

School of Medicine Tecnologico de Monterrey Mexico City Mexico

School of Medicine Universidad Anahuac Mexico City Mexico

The Institute of Liver Disease and Transplantation Dr Rela Institute and Medical Centre and Bharath Institute of Higher Education and Research Chennai India

Citace poskytuje Crossref.org

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$a BACKGROUND: Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions. METHODS: A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita. RESULTS: One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries. CONCLUSIONS: This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.
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