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Pathophysiological and clinical point of view on Kawasaki disease and MIS-C
L. Vaňková, J. Bufka, V. Křížková
Language English Country Singapore
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2008
Free Medical Journals
from 2008
ROAD: Directory of Open Access Scholarly Resources
from 2008
- MeSH
- COVID-19 * MeSH
- Child MeSH
- Mucocutaneous Lymph Node Syndrome * diagnosis MeSH
- Humans MeSH
- Systemic Inflammatory Response Syndrome MeSH
- Inflammation MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
This article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alteration and systemic inflammation under certain circumstances. The two share common pathophysiology, including enhancement of interleukin-1 neutrophils, activation of the inflammasome, pyroptosis, or NETosis. Moreover, the clinical presentation of the diseases overlaps. However, they are indeed two separate diseases, proven by the differences in the epidemiological and etiological aspects and the pathophysiological processes involved in the development and frequency of some clinical signs. This article highlights potentially exciting areas that have not yet been studied in detail, which could help better understand the development of these diseases.
References provided by Crossref.org
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