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The cytisine-enriched poly(3-hydroxybutyrate) fibers for sustained-release dosage form
A. Czerniecka-Kubicka, M. Skotnicki, W. Gonciarz, I. Zarzyka, B. Jadach, L. Lovecká, K. Maternia-Dudzik, M. Kovářová, M. Pyda, P. Tutka, V. Sedlařík
Language English Country Netherlands
Document type Journal Article
- MeSH
- Calorimetry, Differential Scanning MeSH
- 3-Hydroxybutyric Acid MeSH
- Delayed-Action Preparations chemistry MeSH
- Nanofibers * chemistry MeSH
- Polymers * chemistry MeSH
- Publication type
- Journal Article MeSH
The polymeric cytisine-enriched fibers based on poly(3-hydroxybutyrate) were obtained using electrospinning method. The biocompatibility study, advanced thermal analysis and release of cytisine from the poly(3-hydroxybutyrate) fibers were carried out. The nanofibers' morphology was evaluated by scanning electron microscopy. The formation and description of phases during the thermal processes of fibers by the advanced thermal analysis were examined. The new quantitative thermal analysis of polymeric fibers with cytisine phases based on vibrational, solid and liquid heat capacities was presented. The apparent heat capacity of fibers was measured using the standard differential scanning calorimetry. The quantitative analysis allowed for the study of the glass transition and melting/crystallization process. The mobile amorphous fraction, degree of crystallinity and rigid amorphous fraction were determined depending on the thermal history of semicrystalline polymeric fibers. Furthermore, the cytisine dissolution behaviour was studied. It was observed that the kinetic of the release from polymeric nanofiber is delayed than for the marketed product. The immunosafety of the tested polymeric nanofibers with cytisine was confirmed by the Food and Drug Agency Guidance as well as the European Medicines Agency. The polymeric matrix with cytisine seems to be a promising candidate for the prolonged release formulation.
Department of Biophysics Poznan University of Medical Sciences 60 780 Poznan Poland
Department of Chemistry Rzeszow University of Technology 35 959 Rzeszow Poland
National Drug and Alcohol Research Centre University of New South Wales Sydney NSW Australia
References provided by Crossref.org
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- $a Czerniecka-Kubicka, Anna $u Department of Experimental and Clinical Pharmacology, Medical College of Rzeszow University, The University of Rzeszow, 35-310 Rzeszow, Poland; Centre of Polymer Systems, Tomas Bata University in Zlin, trida Tomase Bati 5678, 760-01 Zlin, Czech Republic. Electronic address: aczerniecka@ur.edu.pl
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- $a The cytisine-enriched poly(3-hydroxybutyrate) fibers for sustained-release dosage form / $c A. Czerniecka-Kubicka, M. Skotnicki, W. Gonciarz, I. Zarzyka, B. Jadach, L. Lovecká, K. Maternia-Dudzik, M. Kovářová, M. Pyda, P. Tutka, V. Sedlařík
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- $a The polymeric cytisine-enriched fibers based on poly(3-hydroxybutyrate) were obtained using electrospinning method. The biocompatibility study, advanced thermal analysis and release of cytisine from the poly(3-hydroxybutyrate) fibers were carried out. The nanofibers' morphology was evaluated by scanning electron microscopy. The formation and description of phases during the thermal processes of fibers by the advanced thermal analysis were examined. The new quantitative thermal analysis of polymeric fibers with cytisine phases based on vibrational, solid and liquid heat capacities was presented. The apparent heat capacity of fibers was measured using the standard differential scanning calorimetry. The quantitative analysis allowed for the study of the glass transition and melting/crystallization process. The mobile amorphous fraction, degree of crystallinity and rigid amorphous fraction were determined depending on the thermal history of semicrystalline polymeric fibers. Furthermore, the cytisine dissolution behaviour was studied. It was observed that the kinetic of the release from polymeric nanofiber is delayed than for the marketed product. The immunosafety of the tested polymeric nanofibers with cytisine was confirmed by the Food and Drug Agency Guidance as well as the European Medicines Agency. The polymeric matrix with cytisine seems to be a promising candidate for the prolonged release formulation.
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