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Naringin inhibits P2X4 receptor expression on satellite glial cells in the neonatal rat dorsal root ganglion

H. Wang, L. Chen, J. Xing, X. Shi, C. Xu

. 2023 ; 21 (4) : 193-199. [pub] 20231204

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24002964

Grantová podpora
20232ACB206020 Jiangxi Provincial Natural Science Foundation - China
20202BAB206027 Jiangxi Provincial Natural Science Foundation - China
2022233 Jiangxi Province Human Resources and Social Security Department) - China

Naringin inhibits inflammation and oxidative stress, the P2 purinoreceptor X4 receptor (P2X4R) is associated with glial cell activation and inflammation, the purpose of this study is to investigate the effects of naringin on P2X4 receptor expression on satellite glial cells (SGCs) and its possible mechanisms. ATP promoted the SGC activation and upregulated P2X4R expression; naringin inhibited SGC activation, decreased expression of P2X4R, P38 MAPK/ERK, and NF-κB, and reduced levels of Ca2+, TNF-α, and IL-1β in SGCs in an ATP-containing environment. These findings suggest that naringin attenuates the ATP-induced SGC activation and reduces P2X4R expression via the Ca2+-P38 MAPK/ERK-NF-κB pathway.

Citace poskytuje Crossref.org

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