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Proteomic Profiling of Dilated Cardiomyopathy Plasma Samples ─ Searching for Biomarkers with Potential to Predict the Outcome of Therapy
J. Klimentova, P. Rehulka, J. Stulik, V. Vozandychova, H. Rehulkova, I. Jurcova, M. Lazarova, R. Aiglova, J. Dokoupil, J. Hrecko, R. Pudil
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- biologické markery MeSH
- dilatační kardiomyopatie * terapie MeSH
- hemokoagulace MeSH
- lidé MeSH
- proteom genetika MeSH
- proteomika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Determination of the prognosis and treatment outcomes of dilated cardiomyopathy is a serious problem due to the lack of valid specific protein markers. Using in-depth proteome discovery analysis, we compared 49 plasma samples from patients suffering from dilated cardiomyopathy with plasma samples from their healthy counterparts. In total, we identified 97 proteins exhibiting statistically significant dysregulation in diseased plasma samples. The functional enrichment analysis of differentially expressed proteins uncovered dysregulation in biological processes like inflammatory response, wound healing, complement cascade, blood coagulation, and lipid metabolism in dilated cardiomyopathy patients. The same proteome approach was employed in order to find protein markers whose expression differs between the patients well-responding to therapy and nonresponders. In this case, 45 plasma proteins revealed statistically significant different expression between these two groups. Of them, fructose-1,6-bisphosphate aldolase seems to be a promising biomarker candidate because it accumulates in plasma samples obtained from patients with insufficient treatment response and with worse or fatal outcome. Data are available via ProteomeXchange with the identifier PXD046288.
Citace poskytuje Crossref.org
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- $a Klimentova, Jana $u Faculty of Military Health Sciences, Department of Molecular Pathology and Biology, University of Defence, Trebesska 1575, Hradec Kralove 50001, Czech Republic $u The first Department of Internal Medicine - Cardioangiology, Medical Faculty of Charles University in Hradec Kralove and University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 50005, Czech Republic $1 https://orcid.org/0000000326006438 $7 xx0135751
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- $a Determination of the prognosis and treatment outcomes of dilated cardiomyopathy is a serious problem due to the lack of valid specific protein markers. Using in-depth proteome discovery analysis, we compared 49 plasma samples from patients suffering from dilated cardiomyopathy with plasma samples from their healthy counterparts. In total, we identified 97 proteins exhibiting statistically significant dysregulation in diseased plasma samples. The functional enrichment analysis of differentially expressed proteins uncovered dysregulation in biological processes like inflammatory response, wound healing, complement cascade, blood coagulation, and lipid metabolism in dilated cardiomyopathy patients. The same proteome approach was employed in order to find protein markers whose expression differs between the patients well-responding to therapy and nonresponders. In this case, 45 plasma proteins revealed statistically significant different expression between these two groups. Of them, fructose-1,6-bisphosphate aldolase seems to be a promising biomarker candidate because it accumulates in plasma samples obtained from patients with insufficient treatment response and with worse or fatal outcome. Data are available via ProteomeXchange with the identifier PXD046288.
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