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Synthesis of [3 H]Org24598 using in-house prepared [3 H]MeI

M. Kriegelstein, G. Nováková, A. Marek

. 2024 ; 67 (3) : 91-103. [pub] 20240114

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24006915

Grantová podpora
RVO 61388963 Czech Academy of Sciences

The synthesis of tritium-labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in-house prepared tritium-labelled alkylating agent ([3 H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.

Citace poskytuje Crossref.org

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