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Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity

AK. Yadav, H. Polasek-Sedlackova

. 2024 ; 7 (1) : 167. [pub] 20240209

Language English Country England, Great Britain

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc24007167

Grant support
22-20303M Grantová Agentura České Republiky (Grant Agency of the Czech Republic)
22-20303M Grantová Agentura České Republiky (Grant Agency of the Czech Republic)

Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.

References provided by Crossref.org

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