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Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
J. Yang, AA. Huggins, D. Sun, CL. Baird, CC. Haswell, JL. Frijling, M. Olff, M. van Zuiden, SBJ. Koch, L. Nawijn, DJ. Veltman, B. Suarez-Jimenez, X. Zhu, Y. Neria, AR. Hudson, SC. Mueller, JT. Baker, LAM. Lebois, ML. Kaufman, R. Qi, GM. Lu, P....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
IK2 RX002922
RRD VA - United States
IK2 CX001680
CSRD VA - United States
R01 MH105535
NIMH NIH HHS - United States
R01 MH116147
NIMH NIH HHS - United States
R01 MH119227
NIMH NIH HHS - United States
R56 AG058854
NIA NIH HHS - United States
T32 MH018931
NIMH NIH HHS - United States
R01 MH129832
NIMH NIH HHS - United States
R01 AG059874
NIA NIH HHS - United States
P41 EB015922
NIBIB NIH HHS - United States
P30 HD003352
NICHD NIH HHS - United States
UL1 TR001863
NCATS NIH HHS - United States
R21 MH112956
NIMH NIH HHS - United States
K01 MH118428
NIMH NIH HHS - United States
R01 AG067103
NIA NIH HHS - United States
R01 MH105355
NIMH NIH HHS - United States
R01 MH111671
NIMH NIH HHS - United States
R01 MH106574
NIMH NIH HHS - United States
IK1 RX002325
RRD VA - United States
R01 MH129742
NIMH NIH HHS - United States
I01 RX000622
RRD VA - United States
U54 EB020403
NIBIB NIH HHS - United States
R01 MH117601
NIMH NIH HHS - United States
R01 MH043454
NIMH NIH HHS - United States
R21 MH102634
NIMH NIH HHS - United States
R01 MH131532
NIMH NIH HHS - United States
K01 MH118467
NIMH NIH HHS - United States
NLK
Free Medical Journals
od 1994 do Před 1 rokem
PubMed Central
od 2010 do Před 1 rokem
Europe PubMed Central
od 2010 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1994-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- emoce MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozek MeSH
- posttraumatická stresová porucha * psychologie MeSH
- prefrontální mozková kůra MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.
ARQ National Psychotrauma Centre Diemen The Netherlands
Center for Healthy Minds University of Wisconsin Madison Madison WI USA
Comprehensive Injury Center Medical College of Wisconsin Milwaukee WI USA
Del Monte Institute for Neuroscience University of Rochester Medical Center Rochester NY USA
Department of Clinical Psychology University of Groningen Groningen The Netherlands
Department of Comparative Medicine Yale University New Haven CT USA
Department of Experimental Clinical and Health Psychology Ghent University Ghent Belgium
Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Jiangsu China
Department of Neurology University of Utah Salt Lake City UT USA
Department of Neuroscience Yale University New Haven CT USA
Department of Psychiatry Amsterdam University Medical Center Amsterdam The Netherlands
Department of Psychiatry and Behavioral Science Texas A and M University College Station TX USA
Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
Department of Psychiatry Columbia University Medical Center New York NY USA
Department of Psychiatry Harvard Medical School Boston MA USA
Department of Psychiatry of Behavioral Sciences Baylor College of Medicine Houston TX USA
Department of Psychiatry Stellenbosch University Cape Town South Africa
Department of Psychiatry University of Michigan Ann Arbor MI USA
Department of Psychiatry University of Minnesota Minneapolis MN USA
Department of Psychiatry University of Wisconsin Madison Madison WI USA
Department of Psychiatry Yale University School of Medicine New Haven CT USA
Department of Psychology and Neuroscience Baylor University Waco TX USA
Department of Psychology The Education University of Hong Kong Hong Kong China
Department of Psychology University of Chinese Academy of Sciences Beijing China
Department of Psychology University of Wisconsin Madison Madison WI USA
Department of Psychology University of Wisconsin Milwaukee Milwaukee WI USA
Department of Psychology Vanderbilt University Nashville TN USA
Department of Psychology Yale University New Haven CT USA
Department of Radiology Washington University in St Louis St Louis MO USA
Division of Clinical Neuroscience National Center for PTSD West Haven CT USA
Division of Depression and Anxiety Disorders McLean Hospital Belmont MA USA
Division of Women's Mental Health McLean Hospital Belmont MA USA
Duke UNC Brain Imaging and Analysis Center Duke University Durham NC USA
George E Wahlen Veterans Affairs Medical Center Salt Lake City UT USA
Institute for Technology in Psychiatry McLean Hospital Harvard University Belmont MA USA
Institute of Medical Psychology and Systems Neuroscience University of Münster Münster Germany
Minneapolis VA Health Care System Minneapolis MN USA
Munroe Meyer Institute University of Nebraska Medical Center Omaha NE USA
New York State Psychiatric Institute New York NY USA
Citace poskytuje Crossref.org
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