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Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation
JL. Piñana, G. Tridello, A. Xhaard, L. Wendel, J. Montoro, L. Vazquez, I. Heras, P. Ljungman, M. Mikulska, U. Salmenniemi, A. Perez, N. Kröger, J. Cornelissen, E. Sala, R. Martino, C. Geurten, J. Byrne, J. Maertens, T. Kerre, M. Martin, MJ....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
NLK
Free Medical Journals
od 1997 do Před 1 rokem
Open Access Digital Library
od 1997-04-01
PubMed
37440459
DOI
10.1093/infdis/jiad268
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- infekce dýchací soustavy * epidemiologie etiologie farmakoterapie MeSH
- infekce viry z čeledi Paramyxoviridae * epidemiologie MeSH
- kohortové studie MeSH
- lidé MeSH
- lymfopenie * MeSH
- Metapneumovirus * MeSH
- retrospektivní studie MeSH
- transplantace hematopoetických kmenových buněk * škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area. METHODS: This retrospective multicenter cohort study examined the epidemiology, clinical characteristics, and risk factors for poor outcomes associated with human metapneumovirus (hMPV) infections in recipients of allo-HCT. RESULTS: We included 428 allo-HCT recipients who developed 438 hMPV infection episodes between January 2012 and January 2019. Most recipients were adults (93%). hMPV infections were diagnosed at a median of 373 days after allo-HCT. The infections were categorized as upper respiratory tract disease (URTD) or lower respiratory tract disease (LRTD), with 60% and 40% of cases, respectively. Patients with hMPV LRTD experienced the infection earlier in the transplant course and had higher rates of lymphopenia, neutropenia, corticosteroid use, and ribavirin therapy. Multivariate analysis identified lymphopenia and corticosteroid use (>30 mg/d) as independent risk factors for LRTD occurrence. The overall mortality at day 30 after hMPV detection was 2% for URTD, 12% for possible LRTD, and 21% for proven LRTD. Lymphopenia was the only independent risk factor associated with day 30 mortality in LRTD cases. CONCLUSIONS: These findings highlight the significance of lymphopenia and corticosteroid use in the development and severity of hMPV infections after allo-HCT, with lymphopenia being a predictor of higher mortality in LRTD cases.
Antwerp University Hospital Edegem Belgium
Azienda Ospedaliera Universitaria Integrata Verona Verona Italy
Centre Hospitalier Universitaire de Liege Liege Belgium
Department for Stem Cell Transplantation University Medical Center Hamburg Eppendorf Hamburg Germany
Department of Internal Medicine 3 University Hospital of Ulm Ulm Germany
Department of Medicine Huddinge Karolinska Institutet Stockholm Sweden
Department of Medicine University of Valencia Valencia Spain
Faculty of Medicine Hebrew University of Jerusalem Hadassah Medical Center Jerusalem Israel
Hannover Medical School Hannover Germany
Hematology Department Birmingham Children's Hospital Birmingham United Kingdom
Hematology Department Erasmus Medical Center Cancer Institute Rotterdam The Netherlands
Hematology Department Ghent University Hospital Gent Belgium
Hematology Department Hospital Clinic Barcelona Spain
Hematology Department Hospital Clinico Universitario de Salamanca Salamanca Spain
Hematology Department Hospital Clinico Universitario de Valencia Valencia Spain
Hematology Department Hospital de la Princesa Madrid Spain
Hematology Department Hospital de la Santa Creu 1 Sant Pau Barcelona Spain
Hematology Department Hospital Morales Meseguer Murcia Spain
Hematology Department Hospital Regional de Málaga Malaga Spain
Hematology Department Hospital Universitario Sanitas La Zarzuela Madrid Spain
Hematology Department Leicester Royal Infirmary Leicester United Kingdom
Hematology Department Nottingham University Nottingham United Kingdom
Hematology Department Tor Vergata University of Rome Rome Italy
Hematology Department University Hospital Gasthuisberg Leuven Belgium
Hematology Department University of Freiburg Freiburg Germany
Hematology División Hospital Universitario y Politécnico La Fe Valencia Spain
Institut Català de Oncología Hospital Duran i Reynals Barcelona Spain
Institution of Hematology Rabin Medical Center Petach Tikva Israel
IRCCS Ospedale Policlinico San Martino Genova Italy
Leiden Study Unit EBMT Leiden The Netherlands
Masaryk University Hospital Brno Brno Czech Republic
Nijmegen Medical Centre Nijmegen The Netherlands
Rambam Medical Center Haifa Israel
Sackler School of Medicine Tel Aviv University Tel Aviv Israel
Service d'Hématologie Greffe Hôpital Saint Louis Université Paris Diderot Paris France
The Children`s Hospital at Westmead Sydney Australia
University Medical Center Groningen University of Groningen Groningen The Netherlands
Citace poskytuje Crossref.org
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