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Implementation and validation of a Bayesian method for accurately forecasting duration of optimal pharmacodynamic target attainment with dalbavancin during long-term use for subacute and chronic staphylococcal infections
PG. Cojutti, M. Gatti, N. Punt, J. Douša, E. Zamparini, S. Tedeschi, P. Viale, F. Pea
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- antibakteriální látky * terapeutické užití farmakologie MeSH
- Bayesova věta MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- stafylokokové infekce * farmakoterapie MeSH
- Staphylococcus MeSH
- teikoplanin terapeutické užití farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Dalbavancin is increasingly being used for long-term treatment of subacute and chronic staphylococcal infections. In this study, a new Bayesian model was implemented and validated using MwPharm software for accurately forecasting the duration of pharmacodynamic target attainment above the efficacy thresholds of 4.02 mg/L or 8.04 mg/L against staphylococci. Forecasting accuracy improved substantially with the a posteriori approach compared with the a priori approach, particularly when two measured concentrations were used. This strategy may help clinicians to estimate the duration of optimal exposure with dalbavancin in the context of long-term treatment.
Clinical Pharmacology Unit IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy
Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy
Infectious Diseases Unit IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy
Citace poskytuje Crossref.org
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- $a Cojutti, Pier Giorgio $u Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy; Clinical Pharmacology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. Electronic address: piergiorgio.cojutti@unibo.it
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- $a Gatti, Milo $u Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy; Clinical Pharmacology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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