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YAP Signaling Regulates the Cellular Uptake and Therapeutic Effect of Nanoparticles
M. Cassani, S. Fernandes, J. Oliver-De La Cruz, H. Durikova, J. Vrbsky, M. Patočka, V. Hegrova, S. Klimovic, J. Pribyl, D. Debellis, P. Skladal, F. Cavalieri, F. Caruso, G. Forte
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
Grantová podpora
NU23J-08-00035
Ministerstvo Zdravotnictví Ceské Republiky
800924
H2020 Marie Skłodowska-Curie Actions
CZ.02.1.01/0.0/0.0/18_046/0015974
European Regional Development Fund
CZ.02.1.01/0.0/0.0/16_019/0000868
European Regional Development Fund
CZ.02.1.01/0.0/0.0/15_003/0000492
European Regional Development Fund
NLK
Directory of Open Access Journals
od 2014
PubMed Central
od 2014
Europe PubMed Central
od 2014
ProQuest Central
od 2014-12-01
Open Access Digital Library
od 2014-01-01
Open Access Digital Library
od 2014-12-01
Wiley-Blackwell Open Access Titles
od 2014
ROAD: Directory of Open Access Scholarly Resources
od 2014
PubMed
37946710
DOI
10.1002/advs.202302965
Knihovny.cz E-zdroje
- MeSH
- lidé MeSH
- nanočástice * MeSH
- signální proteiny YAP MeSH
- signální transdukce fyziologie MeSH
- triple-negativní karcinom prsu * farmakoterapie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Interactions between living cells and nanoparticles are extensively studied to enhance the delivery of therapeutics. Nanoparticles size, shape, stiffness, and surface charge are regarded as the main features able to control the fate of cell-nanoparticle interactions. However, the clinical translation of nanotherapies has so far been limited, and there is a need to better understand the biology of cell-nanoparticle interactions. This study investigates the role of cellular mechanosensitive components in cell-nanoparticle interactions. It is demonstrated that the genetic and pharmacologic inhibition of yes-associated protein (YAP), a key component of cancer cell mechanosensing apparatus and Hippo pathway effector, improves nanoparticle internalization in triple-negative breast cancer cells regardless of nanoparticle properties or substrate characteristics. This process occurs through YAP-dependent regulation of endocytic pathways, cell mechanics, and membrane organization. Hence, the study proposes targeting YAP may sensitize triple-negative breast cancer cells to chemotherapy and increase the selectivity of nanotherapy.
Department of Bioanalytical Instrumentation CEITEC Masaryk University Brno 60200 Czech Republic
Department of Chemical Engineering The University of Melbourne Parkville Victoria 3010 Australia
Institute for Bioengineering of Catalonia Barcelona Spain
International Clinical Research Center St Anne's University Hospital Brno 60200 Czech Republic
NenoVision Purkynova 649 127 Brno 61200 Czech Republic
School of Science RMIT University Melbourne 3000 Victoria Australia
Citace poskytuje Crossref.org
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