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Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies
Y. Li, A. Saul, B. Taylor, AL. Ponsonby, S. Simpson-Yap, L. Blizzard, S. Broadley, J. Lechner-Scott, Ausimmune/AusLong Investigators Group, R. Karabudak, F. Patti, S. Eichau, M. Onofrj, S. Ozakbas, D. Horakova, E. Kubala Havrdova, F....
Language English Country Germany
Document type Journal Article
Grant support
14-031
Multiple Sclerosis Australia
NLK
ProQuest Central
from 1997-04-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-04-01 to 1 year ago
- MeSH
- Multiple Sclerosis, Chronic Progressive * epidemiology etiology MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Multicenter Studies as Topic MeSH
- Recurrence MeSH
- Risk Factors MeSH
- Multiple Sclerosis * epidemiology etiology MeSH
- Case-Control Studies MeSH
- Age of Onset MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Australia MeSH
It is unknown whether the currently known risk factors of multiple sclerosis reflect the etiology of progressive-onset multiple sclerosis (POMS) as observational studies rarely included analysis by type of onset. We designed a case-control study to examine associations between environmental factors and POMS and compared effect sizes to relapse-onset MS (ROMS), which will offer insights into the etiology of POMS and potentially contribute to prevention and intervention practice. This study utilizes data from the Primary Progressive Multiple Sclerosis (PPMS) Study and the Australian Multi-center Study of Environment and Immune Function (the AusImmune Study). This report outlines the conduct of the PPMS Study, whether the POMS sample is representative, and the planned analysis methods. The study includes 155 POMS, 204 ROMS, and 558 controls. The distributions of the POMS were largely similar to Australian POMS patients in the MSBase Study, with 54.8% female, 85.8% POMS born before 1970, mean age of onset of 41.44 ± 8.38 years old, and 67.1% living between 28.9 and 39.4° S. The POMS were representative of the Australian POMS population. There are some differences between POMS and ROMS/controls (mean age at interview: POMS 55 years vs. controls 40 years; sex: POMS 53% female vs. controls 78% female; location of residence: 14.3% of POMS at a latitude ≤ 28.9°S vs. 32.8% in controls), which will be taken into account in the analysis. We discuss the methodological issues considered in the study design, including prevalence-incidence bias, cohort effects, interview bias and recall bias, and present strategies to account for it. Associations between exposures of interest and POMS/ROMS will be presented in subsequent publications.
Aarhus University Hospital Aarhus Denmark
AHEPA University Hospital Thessaloniki Greece
Al Zahra Hospital Isfahan Iran
American University of Beirut Medical Center Beirut Lebanon
Austin Health Melbourne Australia
Bombay Hospital Institute of Medical Sciences Mumbai India
Central Clinical School Monash University Melbourne Australia
Centro Hospitalar Universitario de Sao Joao Porto Portugal
Charles University Prague and General University Hospital Prague Czech Republic
CHUM and Universite de Montreal Montreal Canada
CSSS Saint Jérôme Saint Jerome Canada
Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia Catania Italy
Department of Medicine CORe University of Melbourne Melbourne Australia
Department of Medicine School of Clinical Sciences Monash University Melbourne Australia
Department of Medicine The University of Melbourne Melbourne Australia
Department of Neurology Neroimmunology Centre Royal Melbourne Hospital Melbourne Australia
Dipartimento di Scienze Biomediche e Neuromotorie Università di Bologna Bologna Italy
Dokuz Eylul University Konak Izmir Turkey
Faculty of Health Sciences University Fernando Pessoa Porto Portugal
Faculty of Medicine of Tunis University of Tunis El Manar 1007 Tunis Tunisia
Florey Institute for Neuroscience The University of Melbourne Melbourne VIC Australia
Florey Institute for Neuroscience University of Melbourne Melbourne VIC Australia
Golestan University of Medical Sciences Gogan Iran
Groene Hart Ziekenhuis Gouda Netherlands
Hacettepe University Ankara Turkey
Hospital Clinic de Barcelona Barcelona Spain
Hospital Clinico San Carlos Madrid Spain
Hospital General Universitario de Alicante Alicante Spain
Hospital Germans Trias i Pujol Badalona Spain
Hospital Universitario Donostia and IIS Biodonostia San Sebastián Spain
Hospital Universitario Virgen Macarena Seville Spain
Hunter Medical Research Institute University of Newcastle Callaghan Australia
IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy
Isfahan University of Medical Sciences Isfahan Iran
King Fahad Specialist Hospital Dammam Khobar Saudi Arabia
Monash Medical Centre Melbourne Australia
Monash University Melbourne Australia
Nemocnice Jihlava Jihlava Czech Republic
Pelt and Hasselt University Hasselt Belgium
Royal Brisbane and Women's Hospital Brisbane Australia
Royal Victoria Hospital Belfast UK
S Maria delle Croci Hospital AUSL Romagna Ravenna Italy
School for Mental Health and Neuroscience Maastricht University Maastricht The Netherlands
School of Medicine and Dentistry Griffith University Brisbane QLD Australia
South Eastern HSC Trust Belfast UK
St Vincent's University Hospital Dublin Ireland
The Alfred Hospital Melbourne Australia
Universitary Hospital Ghent Ghent Belgium
University College Dublin Dublin Ireland
University G d'Annunzio Chieti Italy
University Hospital Center Zagreb Zagreb Croatia
University of Florence Florence Italy
University of Queensland Brisbane Australia
University of Zagreb School of Medicine Zagreb Croatia
UOS Sclerosi Multipla AOU Policlinico G Rodloico San Marco University of Catania Catania Italy
References provided by Crossref.org
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