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Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses
N. Banaj, D. Vecchio, F. Piras, P. De Rossi, J. Bustillo, S. Ciufolini, P. Dazzan, M. Di Forti, EW. Dickie, JM. Ford, P. Fuentes-Claramonte, O. Gruber, A. Guerrero-Pedraza, HK. Hamilton, FM. Howells, B. Kraemer, SM. Lawrie, DH. Mathalon, R....
Language English Country England, Great Britain
Document type Meta-Analysis, Journal Article
Grant support
P50 MH094268
NIMH NIH HHS - United States
R01 MH105660
NIMH NIH HHS - United States
R01 MH076989
NIMH NIH HHS - United States
R01 MH116147
NIMH NIH HHS - United States
IK6 CX002519
CSRD VA - United States
R01 MH092443
NIMH NIH HHS - United States
R01 MH121246
NIMH NIH HHS - United States
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1997-01-01
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Psychology Database (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Cerebral Cortex diagnostic imaging MeSH
- Neuroimaging MeSH
- Schizophrenia * genetics MeSH
- Syndrome MeSH
- Parietal Lobe MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
Converging evidence suggests that schizophrenia (SZ) with primary, enduring negative symptoms (i.e., Deficit SZ (DSZ)) represents a distinct entity within the SZ spectrum while the neurobiological underpinnings remain undetermined. In the largest dataset of DSZ and Non-Deficit (NDSZ), we conducted a meta-analysis of data from 1560 individuals (168 DSZ, 373 NDSZ, 1019 Healthy Controls (HC)) and a mega-analysis of a subsampled data from 944 individuals (115 DSZ, 254 NDSZ, 575 HC) collected across 9 worldwide research centers of the ENIGMA SZ Working Group (8 in the mega-analysis), to clarify whether they differ in terms of cortical morphology. In the meta-analysis, sites computed effect sizes for differences in cortical thickness and surface area between SZ and control groups using a harmonized pipeline. In the mega-analysis, cortical values of individuals with schizophrenia and control participants were analyzed across sites using mixed-model ANCOVAs. The meta-analysis of cortical thickness showed a converging pattern of widespread thinner cortex in fronto-parietal regions of the left hemisphere in both DSZ and NDSZ, when compared to HC. However, DSZ have more pronounced thickness abnormalities than NDSZ, mostly involving the right fronto-parietal cortices. As for surface area, NDSZ showed differences in fronto-parietal-temporo-occipital cortices as compared to HC, and in temporo-occipital cortices as compared to DSZ. Although DSZ and NDSZ show widespread overlapping regions of thinner cortex as compared to HC, cortical thinning seems to better typify DSZ, being more extensive and bilateral, while surface area alterations are more evident in NDSZ. Our findings demonstrate for the first time that DSZ and NDSZ are characterized by different neuroimaging phenotypes, supporting a nosological distinction between DSZ and NDSZ and point toward the separate disease hypothesis.
Biomedical Network Research Centre on Mental Health Instituto de Salud Carlos 3 Madrid Spain
CARE National Institute of Mental Health Klecany Czech Republic
Center for the Neurobiology of Learning and Memory University of California Irvine Irvine CA USA
Child and Adolescence Neuropsychiatry Unit Bambino Gesù Children's Hospital IRCCS Rome Italy
Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD USA
Department of child and adolescent psychiatry TU Dresden Dresden Saxony Germany
Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD USA
Department of Pharmacology Johns Hopkins University School of Medicine Baltimore MD USA
Department of Psychiatry and Behavioral Sciences University of California San Francisco CA USA
Department of Psychiatry Johns Hopkins University School of Medicine Baltimore MD USA
Department of Psychiatry University of California Irvine Newfoundland NJ NJ 07435 USA
Department of Psychiatry University of Toronto Temerty Faculty of Medicine Toronto ON Canada
Department of Psychiatry University of Toronto Toronto ON Canada
Division of Psychiatry University of Edinburgh Edinburg EH10 5HF UK
FIMDAG Sisters Hospitallers Research Foundation Barcelona Spain
Hospital Benito Menni CASM Barcelona Spain
Imaging of mood and anxiety related disorders Barcelona 08036 Spain
Kimel Family Lab Centre for Addiction and Mental Health Toronto ON Canada
Medicina University of Barcelona Barcelona 08036 Spain
Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA
Psichiatry and Neuroscience University of New Mexico Albuquerque NM USA
Psychiatry and Human Behavior University of California Irvine Orange CA 92868 USA
Psychosis Studies Institute of Psychiatry Psychology and Neurology King's College London London UK
San Francisco VA Health Care System San Francisco CA USA
West Region Institute of Mental Health National Healthcare Group Singapore Singapore
Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
References provided by Crossref.org
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