Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Evaluation of free thyroxine level and bcl11a gene polymorphism with beta-thalassemia

Mayssam M. Salih, Ahmed G. Al-Ziaydi, Aalan Hadi Al-Zamili

. 2024 ; 93 (2) : 160-166. [pub] 20240603

Jazyk angličtina Země Česko

Typ dokumentu klinická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc24010004

Background: Thalassemia` is an autosomal recessive hereditary chronic hemolytic anaemia caused by a partial or total deficit in the production of β -globin chains that make up the main adult haemoglobin. Patients with the beta-thalassemia major have changes in thyroid function and result from thyroid function tests. The B-cell lymphoma /leukemia11A (BCL11A) gene is mainly located in the human chromosome 2p16.1 region; the BCL11A gene can regulate the expression of fetal haemoglobin.The aim: analysis of the association between beta-thalassemia and the BCL11A gene polymorphism in the Iraqi patient and to evaluate the effect of beta-thalassemia on the thyroid gland through the determination of free thyroxine concentration.Method: There were 150 participants in this study, split into two primary groups beta-thalassemia patients and healthy individuals. The result is measured using the ELISA for measurement of free thyroxine and polymerase chain reaction techniques for amplification of B-cell lymphoma /leukemia11A (BCL11A) gene polymorphism.Results: The findings showed a substantial drop in free thyroxine levels in beta-thalassemia patient groups as compared to the control group (P 0.01). The BCL11A gene has three alleles: homozygous CC, heterozygous TC, and homozygous TT. At (431 bais pair and 280 bais pair), (431 bais pair, 280 bais pair, and 195 bais pair), and (431 bais pair, and 195 bais pair), the bands appeared, respectively. The BCL11A rs11886868 gene is affected overall, and research into the causes of thalassemia found a substantial correlation between the BCL11A (rs 11886868) T and C-alleles and thalassemia (P-value = 0.004). The fact that these people have low serum thyroxine (T4) levels highlights the importance of routine screening to assess their endocrine function.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24010004
003      
CZ-PrNML
005      
20241116214606.0
007      
ta
008      
241008s2024 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.31482/mmsl.2023.018 $2 doi
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Salih, Mayssam M. $u Department of Medical Chemistry, College of Medicine, University of Al-Qadisiyah, University Street, 58002, Al- Diwaniyah, Iraq
245    10
$a Evaluation of free thyroxine level and bcl11a gene polymorphism with beta-thalassemia / $c Mayssam M. Salih, Ahmed G. Al-Ziaydi, Aalan Hadi Al-Zamili
520    9_
$a Background: Thalassemia` is an autosomal recessive hereditary chronic hemolytic anaemia caused by a partial or total deficit in the production of β -globin chains that make up the main adult haemoglobin. Patients with the beta-thalassemia major have changes in thyroid function and result from thyroid function tests. The B-cell lymphoma /leukemia11A (BCL11A) gene is mainly located in the human chromosome 2p16.1 region; the BCL11A gene can regulate the expression of fetal haemoglobin.The aim: analysis of the association between beta-thalassemia and the BCL11A gene polymorphism in the Iraqi patient and to evaluate the effect of beta-thalassemia on the thyroid gland through the determination of free thyroxine concentration.Method: There were 150 participants in this study, split into two primary groups beta-thalassemia patients and healthy individuals. The result is measured using the ELISA for measurement of free thyroxine and polymerase chain reaction techniques for amplification of B-cell lymphoma /leukemia11A (BCL11A) gene polymorphism.Results: The findings showed a substantial drop in free thyroxine levels in beta-thalassemia patient groups as compared to the control group (P 0.01). The BCL11A gene has three alleles: homozygous CC, heterozygous TC, and homozygous TT. At (431 bais pair and 280 bais pair), (431 bais pair, 280 bais pair, and 195 bais pair), and (431 bais pair, and 195 bais pair), the bands appeared, respectively. The BCL11A rs11886868 gene is affected overall, and research into the causes of thalassemia found a substantial correlation between the BCL11A (rs 11886868) T and C-alleles and thalassemia (P-value = 0.004). The fact that these people have low serum thyroxine (T4) levels highlights the importance of routine screening to assess their endocrine function.
650    07
$a lidé $7 D006801 $2 czmesh
650    17
$a thyroxin $x krev $7 D013974 $2 czmesh
650    07
$a protoonkogeny $7 D011519 $2 czmesh
650    07
$a polymorfismus genetický $7 D011110 $2 czmesh
650    17
$a beta-talasemie $x genetika $x krev $7 D017086 $2 czmesh
650    07
$a ELISA $x metody $7 D004797 $2 czmesh
650    07
$a alely $7 D000483 $2 czmesh
650    07
$a štítná žláza $x patofyziologie $7 D013961 $2 czmesh
650    07
$a elektroforéza $7 D004586 $2 czmesh
655    _7
$a klinická studie $7 D000068397 $2 czmesh
700    1_
$a Al-Ziaydi, Ahmed G. $u Department of Medical Chemistry, College of Medicine, University of Al-Qadisiyah, University Street, 58002, Al- Diwaniyah, Iraq
700    1_
$a Al-Zamili, Aalan Hadi $u Department of Pediatrics, College of Medicine, University of Al-Qadisiyah, University Street, 58002, Al- Diwaniyah, Iraq
773    0_
$t Vojenské zdravotnické listy $x 0372-7025 $g Roč. 93, č. 2 (2024), s. 160-166 $w MED00011116
856    41
$u https://mmsl.cz/artkey/mms-202402-0002_evaluation-of-free-thyroxine-level-and-bcl11a-gene-polymorphism-with-beta-thalassemia.php $y plný text volně přístupný
910    __
$a ABA008 $b A 3 $c 1073 $y p $z 0
990    __
$a 20240606 $b ABA008
991    __
$a 20241116214556 $b ABA008
999    __
$a ok $b bmc $g 2203017 $s 1219834
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2024 $b 93 $c 2 $d 160-166 $e 20240603 $i 0372-7025 $m Vojenské zdravotnické listy $x MED00011116
LZP    __
$c NLK189 $d 20241116 $b NLK111 $a Actavia-MED00011116-20240606

Najít záznam

Citační ukazatele

Možnosti archivace