This study aimed to investigate the concentration of pregabalin in the plasma of chicks to determine its pharmacokinetic parameters. Pregabalin (300 mg/kg) was administered orally to 42 clinically healthy Ross chicks as part of a randomized controlled study. Blood samples were collected from the jugular vein at 0.5, 1, 2, 4, 8, and 24 h after drug administration from six chicks per each time. The concentrations of pregabalin in the plasma samples were determined using a quantitative HPLC assay, and pharmacokinetic parameters were calculated using the PKSolver program. Pharmacokinetic parameters were determined using a noncom-partmental model. The concentrations of pregabalin were 133.80 ± 2.35, 183.20 ± 3.91, 295.60 ± 2.82, 248.40 ± 7.60, 219.00 ± 2.72 and 154.00 ± 5.50 μg/ml at the times 0.5, 1, 2, 4, 8, and 24 h respectively. The pharmacokinetics parameters were t1/2β 29 h, Tmax 2 h, Cmax 295 μg, Kel 0.023 h-1, MRT 43h, Vd 1.127 L/h/kg, Cl 0.026 L/h/kg and AUC0-∞ 11420.31 μg.h/ml. This study concluded that pregabalin has a long elimination half-life and poor clearance from the animal body, which is reflected in the prolonged impact of its action.

Department of Physiology Biochemistry and Pharmacology College of Veterinary Medicine University of Mosul Mosul Iraq

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