-
Je něco špatně v tomto záznamu ?
Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus
R. Obeid, E. Andrès, R. Češka, B. Hooshmand, RM. Guéant-Rodriguez, GI. Prada, J. Sławek, L. Traykov, B. Ta Van, T. Várkonyi, K. Reiners, . The Vitamin B Consensus Panelists Group
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
not applicable
Wörwag Pharma (Germany)
NLK
Free Medical Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2019-01-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-01
Health & Medicine (ProQuest)
od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
38673453
DOI
10.3390/jcm13082176
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. Data were used to design a two-round Delphi survey to study the level of consensus among 42 experts. Results: The panelists agreed on the need for educational and organizational changes in the current medical practices for diagnosing and treating B12 deficiency. Recognition of clinical symptoms should receive the highest priority in establishing the diagnosis. There is agreement that the serum B12 concentration is useful as a screening marker and methylmalonic acid or homocysteine can support the diagnosis. Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency. Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency. The use of high-dose oral B12 at different frequencies may be considered for long-term treatment. Prophylactic B12 supplementation should be considered for specific high-risk groups. Conclusions: There is a consensus that clinical symptoms need to receive more attention in establishing the diagnosis of B12 deficiency. B12 laboratory markers can support the diagnosis. The severity of clinical symptoms, the causes of B12 deficiency, and the treatment goals govern decisions regarding the route and dose of B12 therapy.
Aging Research Center Karolinska Institute 171 65 Stockholm Sweden
Consultant in Neurology and Clinical Neurophysiology 41844 Wegberg Germany
Department of Internal Medicine University of Szeged 6720 Szeged Hungary
Department of Neurology and Stroke St Adalbert Hospital 80 462 Gdańsk Poland
Department of Neurology Benedictus Klinikum Tutzing 82327 Tutzing Germany
Department of Neurology University Hospital Alexandrovska Medical University 1431 Sofia Bulgaria
Vietnam Institute of Diabetes and Metabolic Disorders Hanoi Medical University Hanoi 116001 Vietnam
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24013030
- 003
- CZ-PrNML
- 005
- 20240726151506.0
- 007
- ta
- 008
- 240723s2024 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/jcm13082176 $2 doi
- 035 __
- $a (PubMed)38673453
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Obeid, Rima $u Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, 66421 Homburg, Germany $1 https://orcid.org/0000000200647029
- 245 10
- $a Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus / $c R. Obeid, E. Andrès, R. Češka, B. Hooshmand, RM. Guéant-Rodriguez, GI. Prada, J. Sławek, L. Traykov, B. Ta Van, T. Várkonyi, K. Reiners, . The Vitamin B Consensus Panelists Group
- 520 9_
- $a Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop a widely accepted expert consensus to guide the practice of diagnosing and treating B12 deficiency. Methods: We conducted a scoping review of the literature published in PubMed since January 2003. Data were used to design a two-round Delphi survey to study the level of consensus among 42 experts. Results: The panelists agreed on the need for educational and organizational changes in the current medical practices for diagnosing and treating B12 deficiency. Recognition of clinical symptoms should receive the highest priority in establishing the diagnosis. There is agreement that the serum B12 concentration is useful as a screening marker and methylmalonic acid or homocysteine can support the diagnosis. Patient lifestyle, disease history, and medications can provide clues to the cause of B12 deficiency. Regardless of the cause of the deficiency, initial treatment with parenteral B12 was regarded as the first choice for patients with acute and severe manifestations of B12 deficiency. The use of high-dose oral B12 at different frequencies may be considered for long-term treatment. Prophylactic B12 supplementation should be considered for specific high-risk groups. Conclusions: There is a consensus that clinical symptoms need to receive more attention in establishing the diagnosis of B12 deficiency. B12 laboratory markers can support the diagnosis. The severity of clinical symptoms, the causes of B12 deficiency, and the treatment goals govern decisions regarding the route and dose of B12 therapy.
- 590 __
- $a NEINDEXOVÁNO
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Andrès, Emmanuel $u Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, France $1 https://orcid.org/0000000279147616
- 700 1_
- $a Češka, Richard $u IIIrd Department of Internal Medicine, Center of Preventive Cardiology, University General Hospital, Charles University in Prague, 110 00 Prague, Czech Republic
- 700 1_
- $a Hooshmand, Babak $u Aging Research Center, Karolinska Institute, 171 65 Stockholm, Sweden $u Department of Neurology, Benedictus Klinikum Tutzing, 82327 Tutzing, Germany $u Department of Psychiatry and Psychotherapy, Ludwig Maximillian University Hospital, 80539 Munich, Germany
- 700 1_
- $a Guéant-Rodriguez, Rosa-Maria $u INSERM, UMR_S1256, NGERE-Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, 54500 Vandoeuvre-lès-Nancy, France $u Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, 54000 Vandoeuvre-lès-Nancy, France
- 700 1_
- $a Prada, Gabriel Ioan $u Clinical Department of the National Institute of Gerontology and Geriatrics "Ana Aslan", University of Medicine and Pharmacy "Carol Davila", 011241 Bucharest, Romania $1 https://orcid.org/0000000247629581
- 700 1_
- $a Sławek, Jarosław $u Department of Neurology & Stroke, St. Adalbert Hospital, 80-462 Gdańsk, Poland $u Department of Neurological-Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdańsk, 80-210 Gdańsk, Poland $1 https://orcid.org/0000000168160877
- 700 1_
- $a Traykov, Latchezar $u Department of Neurology, University Hospital "Alexandrovska", Medical University, 1431 Sofia, Bulgaria
- 700 1_
- $a Ta Van, Binh $u Vietnam Institute of Diabetes and Metabolic Disorders, Hanoi Medical University, Hanoi 116001, Vietnam
- 700 1_
- $a Várkonyi, Tamás $u Department of Internal Medicine, University of Szeged, 6720 Szeged, Hungary $1 https://orcid.org/0000000320577993
- 700 1_
- $a Reiners, Karlheinz $u Consultant in Neurology and Clinical Neurophysiology, 41844 Wegberg, Germany $1 https://orcid.org/0000000210931867
- 700 1_
- $a The Vitamin B Consensus Panelists Group,
- 773 0_
- $w MED00195462 $t Journal of clinical medicine $x 2077-0383 $g Roč. 13, č. 8 (2024)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38673453 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240723 $b ABA008
- 991 __
- $a 20240726151458 $b ABA008
- 999 __
- $a ok $b bmc $g 2125568 $s 1224893
- BAS __
- $a 3
- BAS __
- $a PreBMC-PubMed-not-MEDLINE
- BMC __
- $a 2024 $b 13 $c 8 $e 20240410 $i 2077-0383 $m Journal of clinical medicine $n J Clin Med $x MED00195462
- GRA __
- $a not applicable $p Wörwag Pharma (Germany)
- LZP __
- $a Pubmed-20240723
