-
Je něco špatně v tomto záznamu ?
Maternal and fetal outcomes in multiparous women with Cystic Fibrosis
M. Cohen-Cymberknoh, M. Ariel Dabby, B. Gindi Reiss, J. Melo Tanner, G. Pérez, N. Lechtzin, E. Polverino, J. Perez Miranda, A. Gramegna, S. Aliberti, H. Levine, H. Mussaffi, H. Blau, D. Prais, M. Mei-Zahav, M. Shteinberg, G. Livnat, M. Gur, L....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
- MeSH
- cystická fibróza * komplikace MeSH
- dospělí MeSH
- komplikace těhotenství epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- parita MeSH
- předčasný porod epidemiologie MeSH
- progrese nemoci MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- stupeň závažnosti nemoci MeSH
- těhotenství mnohočetné MeSH
- těhotenství MeSH
- výsledek těhotenství * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Quality of life and survival in Cystic Fibrosis (CF) have improved dramatically, making family planning a feasible option. Maternal and perinatal outcomes in women with CF (wwCF) are similar to those seen in the general population. However, the effect of undergoing multiple pregnancies is unknown. METHODS: A multinational-multicenter retrospective cohort study. Data was obtained from 18 centers worldwide, anonymously, on wwCF 18-45 years old, including disease severity and outcome, as well as obstetric and newborn complications. Data were analyzed, within each individual patient to compare the outcomes of an initial pregnancy (1st or 2nd) with a multigravid pregnancy (≥3) as well as secondary analysis of grouped data to identify risk factors for disease progression or adverse neonatal outcomes. Three time periods were assessed - before, during, and after pregnancy. RESULTS: The study population included 141 wwCF of whom 41 (29%) had ≥3 pregnancies, "multiparous". Data were collected on 246 pregnancies, between 1973 and 2020, 69 (28%) were multiparous. A greater decline in ppFEV1 was seen in multiparous women, primarily in pancreatic insufficient (PI) wwCF and those with two severe (class I-III) mutations. Multigravid pregnancies were shorter, especially in wwCF over 30 years old, who had high rates of prematurity and newborn complications. There was no effect on pulmonary exacerbations or disease-related complications. CONCLUSIONS: Multiple pregnancies in wwCF are associated with accelerated respiratory deterioration and higher rates of preterm births. Therefore, strict follow-up by a multidisciplinary CF and obstetric team is needed in women who desire to carry multiple pregnancies.
Center for Innovative Research on Gender Health Equity University of Pittsburgh Pittsburgh PA USA
Charite Hospital Berlin Germany
Department of Biomedical Sciences Humanitas University Milan Italy
Department of Pediatrics University of Pittsburgh School of Medicine Pittsburgh USA
Department Pathophysiology and Transplantation University of Milan Italy
Faculty of Medicine Hebrew University of Jerusalem Israel
Hospital Universitari Vall d'Hebron Barcelona Spain
Instituto Nacional del Tórax Santiago Chile
IRCCS Humanitas Research Hospital Respiratory Unit Milan Italy
Johns Hopkins University School of Medicine Baltimore MD USA
Pediatric Pulmonary Unit and Cystic Fibrosis Center Hadassah Medical Center Jerusalem Israel
Pediatric Pulmonary Unit Shaare Zedek Medical Center Jerusalem Israel
Pediatric Pulmonology and Cystic Fibrosis Unit Hospital Exequiel González Cortés Chile
Safra Sheba Medical Center Ramat Gan Israel
Wellcome Wolfson Institute for Experimental Medicine Queen's University Belfast Ireland
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24013371
- 003
- CZ-PrNML
- 005
- 20240905133543.0
- 007
- ta
- 008
- 240725e20240511enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.rmed.2024.107654 $2 doi
- 035 __
- $a (PubMed)38735372
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Cohen-Cymberknoh, Malena $u Pediatric Pulmonary Unit and Cystic Fibrosis Center, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Israel. Electronic address: malena@hadassah.org.il
- 245 10
- $a Maternal and fetal outcomes in multiparous women with Cystic Fibrosis / $c M. Cohen-Cymberknoh, M. Ariel Dabby, B. Gindi Reiss, J. Melo Tanner, G. Pérez, N. Lechtzin, E. Polverino, J. Perez Miranda, A. Gramegna, S. Aliberti, H. Levine, H. Mussaffi, H. Blau, D. Prais, M. Mei-Zahav, M. Shteinberg, G. Livnat, M. Gur, L. Bentur, DG. Downey, A. Dagan, I. Golan-Tripto, M. Aviram, P. Mondejar-Lopez, E. Picard, C. Schwarz, P. Jakubec, TM. Kazmerski, H. Amsalem, D. Hochner Celnikier, E. Kerem, J. Reiter
- 520 9_
- $a BACKGROUND: Quality of life and survival in Cystic Fibrosis (CF) have improved dramatically, making family planning a feasible option. Maternal and perinatal outcomes in women with CF (wwCF) are similar to those seen in the general population. However, the effect of undergoing multiple pregnancies is unknown. METHODS: A multinational-multicenter retrospective cohort study. Data was obtained from 18 centers worldwide, anonymously, on wwCF 18-45 years old, including disease severity and outcome, as well as obstetric and newborn complications. Data were analyzed, within each individual patient to compare the outcomes of an initial pregnancy (1st or 2nd) with a multigravid pregnancy (≥3) as well as secondary analysis of grouped data to identify risk factors for disease progression or adverse neonatal outcomes. Three time periods were assessed - before, during, and after pregnancy. RESULTS: The study population included 141 wwCF of whom 41 (29%) had ≥3 pregnancies, "multiparous". Data were collected on 246 pregnancies, between 1973 and 2020, 69 (28%) were multiparous. A greater decline in ppFEV1 was seen in multiparous women, primarily in pancreatic insufficient (PI) wwCF and those with two severe (class I-III) mutations. Multigravid pregnancies were shorter, especially in wwCF over 30 years old, who had high rates of prematurity and newborn complications. There was no effect on pulmonary exacerbations or disease-related complications. CONCLUSIONS: Multiple pregnancies in wwCF are associated with accelerated respiratory deterioration and higher rates of preterm births. Therefore, strict follow-up by a multidisciplinary CF and obstetric team is needed in women who desire to carry multiple pregnancies.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a cystická fibróza $x komplikace $7 D003550
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a těhotenství $7 D011247
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 12
- $a výsledek těhotenství $7 D011256
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a novorozenec $7 D007231
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a parita $7 D010298
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a komplikace těhotenství $x epidemiologie $7 D011248
- 650 _2
- $a progrese nemoci $7 D018450
- 650 _2
- $a předčasný porod $x epidemiologie $7 D047928
- 650 _2
- $a těhotenství mnohočetné $7 D011272
- 650 _2
- $a stupeň závažnosti nemoci $7 D012720
- 650 _2
- $a rizikové faktory $7 D012307
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Ariel Dabby, Maya $u Faculty of Medicine, Hebrew University of Jerusalem, Israel
- 700 1_
- $a Gindi Reiss, Bar $u Safra Sheba Medical Center, Ramat-Gan, Israel
- 700 1_
- $a Melo Tanner, Joel $u Instituto Nacional del Tórax, Santiago, Chile
- 700 1_
- $a Pérez, Gema $u Pediatric Pulmonology and Cystic Fibrosis Unit, Hospital Exequiel González Cortés, Chile
- 700 1_
- $a Lechtzin, Noah $u Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 700 1_
- $a Polverino, Eva $u Hospital Universitari Vall d'Hebron, Barcelona, Spain
- 700 1_
- $a Perez Miranda, Javier $u Hospital Universitari Vall d'Hebron, Barcelona, Spain
- 700 1_
- $a Gramegna, Andrea $u Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Center, Italy; Department Pathophysiology and Transplantation University of Milan, Italy
- 700 1_
- $a Aliberti, Stefano $u Department of Biomedical Sciences, Humanitas University, Milan, Italy; IRCCS Humanitas Research Hospital, Respiratory Unit, Milan, Italy
- 700 1_
- $a Levine, Hagit $u Graub CF Center, Schneider Children's Medical Center, Petach-Tikva and Sackler School of Medicine, Tel-Aviv University, Israel
- 700 1_
- $a Mussaffi, Huda $u Graub CF Center, Schneider Children's Medical Center, Petach-Tikva and Sackler School of Medicine, Tel-Aviv University, Israel
- 700 1_
- $a Blau, Hanna $u Graub CF Center, Schneider Children's Medical Center, Petach-Tikva and Sackler School of Medicine, Tel-Aviv University, Israel
- 700 1_
- $a Prais, Dario $u Graub CF Center, Schneider Children's Medical Center, Petach-Tikva and Sackler School of Medicine, Tel-Aviv University, Israel
- 700 1_
- $a Mei-Zahav, Meir $u Graub CF Center, Schneider Children's Medical Center, Petach-Tikva and Sackler School of Medicine, Tel-Aviv University, Israel
- 700 1_
- $a Shteinberg, Michal $u Pulmonology Institute and CF Center, Carmel Medical Center and the Technion- Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Livnat, Galit $u Pulmonology Institute and CF Center, Carmel Medical Center and the Technion- Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Gur, Michal $u Pediatric Pulmonary Institute and CF Center, Ruth Rappaport Children's Hospital, Rambam Medical Center and the Technion- Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Bentur, Lea $u Pediatric Pulmonary Institute and CF Center, Ruth Rappaport Children's Hospital, Rambam Medical Center and the Technion- Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Downey, Damian G $u Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, Ireland
- 700 1_
- $a Dagan, Adi $u Safra Sheba Medical Center, Ramat-Gan, Israel
- 700 1_
- $a Golan-Tripto, Inbal $u Pediatric Pulmonary Unit, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel
- 700 1_
- $a Aviram, Micha $u Pediatric Pulmonary Unit, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel
- 700 1_
- $a Mondejar-Lopez, Pedro $u Pediatric Pulmonology and Cystic Fibrosis Unit, Hospital Clinico Universitario Virgen de la Arrixaca, Murcia, Spain
- 700 1_
- $a Picard, Elie $u Pediatric Pulmonary Unit, Shaare Zedek Medical Center, Jerusalem, Israel
- 700 1_
- $a Schwarz, Carsten $u Charite Hospital, Berlin, Germany
- 700 1_
- $a Jakubec, Petr $u CF Center, University Hospital Olomouc and Faculty of Medicine, Palacky University, Olomouc, Czech Republic
- 700 1_
- $a Kazmerski, Traci M $u Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, USA; Center for Innovative Research on Gender Health Equity (CONVERGE), University of Pittsburgh, Pittsburgh, PA, USA
- 700 1_
- $a Amsalem, Hagai $u Department of Obstetrics and Gynecology, Mount Scopus, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
- 700 1_
- $a Hochner Celnikier, Drorit $u Department of Obstetrics and Gynecology, Mount Scopus, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
- 700 1_
- $a Kerem, Eitan $u Pediatric Pulmonary Unit and Cystic Fibrosis Center, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Israel
- 700 1_
- $a Reiter, Joel $u Pediatric Pulmonary Unit and Cystic Fibrosis Center, Hadassah Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Israel
- 773 0_
- $w MED00004105 $t Respiratory medicine $x 1532-3064 $g Roč. 228 (20240511), s. 107654
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38735372 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240725 $b ABA008
- 991 __
- $a 20240905133537 $b ABA008
- 999 __
- $a ok $b bmc $g 2143279 $s 1225237
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 228 $c - $d 107654 $e 20240511 $i 1532-3064 $m Respiratory medicine $n Respir Med $x MED00004105
- LZP __
- $a Pubmed-20240725
