-
Je něco špatně v tomto záznamu ?
Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM
J. Lübke, A. Schmid, D. Christen, HNG. Oude Elberink, LFR. Span, M. Niedoszytko, A. Gorska, M. Lange, KV. Gleixner, E. Hadzijusufovic, A. Stefan, I. Angelova-Fischer, R. Zanotti, M. Bonifacio, P. Bonadonna, K. Shoumariyeh, N. von Bubnoff, S....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2016
PubMed Central
od 2016
Europe PubMed Central
od 2016
ROAD: Directory of Open Access Scholarly Resources
od 2016
- MeSH
- biologické markery krev MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- prognóza MeSH
- registrace * MeSH
- senioři MeSH
- systémová mastocytóza * diagnóza krev MeSH
- tryptasy krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Certain laboratory abnormalities correlate with subvariants of systemic mastocytosis (SM) and are often prognostically relevant. To assess the diagnostic and prognostic value of individual serum chemistry parameters in SM, 2607 patients enrolled within the European Competence Network on Mastocytosis and 575 patients enrolled within the German Registry on Eosinophils and Mast Cells were analyzed. For screening and diagnosis of SM, tryptase was identified as the most specific serum parameter. For differentiation between indolent and advanced SM (AdvSM), the following serum parameters were most relevant: tryptase, alkaline phosphatase, β2-microglobulin, lactate dehydrogenase (LDH), albumin, vitamin B12, and C-reactive protein (P < .001). With regard to subvariants of AdvSM, an elevated LDH of ≥260 U/L was associated with multilineage expansion (leukocytosis, r = 0.37, P < .001; monocytosis, r = 0.26, P < .001) and the presence of an associated myeloid neoplasm (P < .001), whereas tryptase levels were highest in mast cell leukemia (MCL) vs non-MCL (308μg/L vs 146μg/L, P = .003). Based on multivariable analysis, the hazard-risk weighted assignment of 1 point to LDH (hazard ratio [HR], 2.1; 95% confidence interval [CI], 1.1-4.0; P = .018) and 1.5 points each to β2-microglobulin (HR, 2.7; 95% CI, 1.4-5.4; P = .004) and albumin (HR, 3.3; 95% CI, 1.7-6.5; P = .001) delineated a highly predictive 3-tier risk classification system (0 points, 8.1 years vs 1 point, 2.5 years; ≥1.5 points, 1.7 years; P < .001). Moreover, serum chemistry parameters enabled further stratification of patients classified as having an International Prognostic Scoring System for Mastocytosis-AdvSM1/2 risk score (P = .027). In conclusion, serum chemistry profiling is a crucial tool in the clinical practice supporting diagnosis and prognostication of SM and its subvariants.
Allergy Unit Verona University Hospital Verona Italy
Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf Aachen Germany
Department of Allergology Medical University of Gdańsk Gdańsk Poland
Department of Biomedicine University Hospital Basel and University of Basel Basel Switzerland
Department of Dermatology and Venereology University Hospital Graz Graz Austria
Department of Dermatology Medical Center Faculty of Medicine University of Freiburg Freiburg Germany
Department of Dermatology Venereology and Allergology Medical University of Gdańsk Gdańsk Poland
Department of Hematology Semmelweis University Budapest Hungary
Department of Medicine Pediatric Dermatology Unit University of Padova Padova Italy
Department of Medicine Section of Hematology Verona University Hospital Verona Italy
Division of Allergy and Clinical Immunology University of Salerno Salerno Italy
Division of Hematology Department of Medical Sciences Uppsala University Uppsala Sweden
Division of Hematology Istanbul Medical School University of Istanbul Istanbul Turkey
German Cancer Consortium Heidelberg Germany
Hematology Unit Fondazione IRCCS Policlinico San Matteo Pavia Italy
Ludwig Boltzmann Institute for Hematology and Oncology Medical University of Vienna Vienna Austria
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24013533
- 003
- CZ-PrNML
- 005
- 20240905134337.0
- 007
- ta
- 008
- 240725s2024 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1182/bloodadvances.2024012756 $2 doi
- 035 __
- $a (PubMed)38593217
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Lübke, Johannes $u Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany $1 https://orcid.org/0000000307671504
- 245 10
- $a Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM / $c J. Lübke, A. Schmid, D. Christen, HNG. Oude Elberink, LFR. Span, M. Niedoszytko, A. Gorska, M. Lange, KV. Gleixner, E. Hadzijusufovic, A. Stefan, I. Angelova-Fischer, R. Zanotti, M. Bonifacio, P. Bonadonna, K. Shoumariyeh, N. von Bubnoff, S. Müller, C. Perkins, C. Elena, L. Malcovati, H. Hagglund, M. Mattsson, R. Parente, J. Varkonyi, AB. Fortina, F. Caroppo, K. Brockow, A. Zink, C. Breynaert, T. Leven, AS. Yavuz, M. Doubek, V. Sabato, T. Schug, K. Hartmann, M. Triggiani, J. Gotlib, O. Hermine, M. Arock, HC. Kluin-Nelemans, J. Panse, WR. Sperr, P. Valent, A. Reiter, J. Schwaab
- 520 9_
- $a Certain laboratory abnormalities correlate with subvariants of systemic mastocytosis (SM) and are often prognostically relevant. To assess the diagnostic and prognostic value of individual serum chemistry parameters in SM, 2607 patients enrolled within the European Competence Network on Mastocytosis and 575 patients enrolled within the German Registry on Eosinophils and Mast Cells were analyzed. For screening and diagnosis of SM, tryptase was identified as the most specific serum parameter. For differentiation between indolent and advanced SM (AdvSM), the following serum parameters were most relevant: tryptase, alkaline phosphatase, β2-microglobulin, lactate dehydrogenase (LDH), albumin, vitamin B12, and C-reactive protein (P < .001). With regard to subvariants of AdvSM, an elevated LDH of ≥260 U/L was associated with multilineage expansion (leukocytosis, r = 0.37, P < .001; monocytosis, r = 0.26, P < .001) and the presence of an associated myeloid neoplasm (P < .001), whereas tryptase levels were highest in mast cell leukemia (MCL) vs non-MCL (308μg/L vs 146μg/L, P = .003). Based on multivariable analysis, the hazard-risk weighted assignment of 1 point to LDH (hazard ratio [HR], 2.1; 95% confidence interval [CI], 1.1-4.0; P = .018) and 1.5 points each to β2-microglobulin (HR, 2.7; 95% CI, 1.4-5.4; P = .004) and albumin (HR, 3.3; 95% CI, 1.7-6.5; P = .001) delineated a highly predictive 3-tier risk classification system (0 points, 8.1 years vs 1 point, 2.5 years; ≥1.5 points, 1.7 years; P < .001). Moreover, serum chemistry parameters enabled further stratification of patients classified as having an International Prognostic Scoring System for Mastocytosis-AdvSM1/2 risk score (P = .027). In conclusion, serum chemistry profiling is a crucial tool in the clinical practice supporting diagnosis and prognostication of SM and its subvariants.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a systémová mastocytóza $x diagnóza $x krev $7 D034721
- 650 _2
- $a prognóza $7 D011379
- 650 12
- $a registrace $7 D012042
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a biologické markery $x krev $7 D015415
- 650 _2
- $a tryptasy $x krev $7 D053802
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Schmid, Alicia $u Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
- 700 1_
- $a Christen, Deborah $u Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany $u Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany $1 https://orcid.org/0000000328395983
- 700 1_
- $a Oude Elberink, Hanneke N G $u Department of Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands $1 https://orcid.org/0000000328442196
- 700 1_
- $a Span, Lambert F R $u Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
- 700 1_
- $a Niedoszytko, Marek $u Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland
- 700 1_
- $a Gorska, Aleksandra $u Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland
- 700 1_
- $a Lange, Magdalena $u Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland $1 https://orcid.org/0000000269671393
- 700 1_
- $a Gleixner, Karoline V $u Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria $u Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- 700 1_
- $a Hadzijusufovic, Emir $u Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria $u Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria $u Department/University Clinic for Companion Animals and Horses, Internal Medicine Small Animals, University Clinic for Small Animals, University of Veterinary Medicine, Vienna, Austria $1 https://orcid.org/0000000174094204
- 700 1_
- $a Stefan, Alex $u University Clinic for Hematology and Oncology, Kepler University Hospital, Johannes Kepler University, Linz, Austria
- 700 1_
- $a Angelova-Fischer, Irena $u Department of Dermatology and Venereology, Allergy Center, Kepler University Hospital, Johannes Kepler University, Linz, Austria
- 700 1_
- $a Zanotti, Roberta $u Department of Medicine, Section of Hematology, Verona University Hospital, Verona, Italy
- 700 1_
- $a Bonifacio, Massimiliano $u Department of Medicine, Section of Hematology, Verona University Hospital, Verona, Italy
- 700 1_
- $a Bonadonna, Patrizia $u Allergy Unit, Verona University Hospital, Verona, Italy
- 700 1_
- $a Shoumariyeh, Khalid $u Department of Medicine I, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany $u German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany
- 700 1_
- $a von Bubnoff, Nikolas $u Department of Medicine I, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany $u German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany $u Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany $1 https://orcid.org/0000000195938947
- 700 1_
- $a Müller, Sabine $u Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
- 700 1_
- $a Perkins, Cecelia $u Stanford Cancer Institute, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA
- 700 1_
- $a Elena, Chiara $u Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
- 700 1_
- $a Malcovati, Luca $u Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy $1 https://orcid.org/0000000214601611
- 700 1_
- $a Hagglund, Hans $u Division of Hematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
- 700 1_
- $a Mattsson, Mattias $u Division of Hematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
- 700 1_
- $a Parente, Roberta $u Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy
- 700 1_
- $a Varkonyi, Judit $u Department of Hematology, Semmelweis University, Budapest, Hungary
- 700 1_
- $a Fortina, Anna Belloni $u Department of Medicine, Pediatric Dermatology Unit, University of Padova, Padova, Italy
- 700 1_
- $a Caroppo, Francesca $u Department of Medicine, Pediatric Dermatology Unit, University of Padova, Padova, Italy $1 https://orcid.org/0000000335830816
- 700 1_
- $a Brockow, Knut $u Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany $1 https://orcid.org/0000000227753681
- 700 1_
- $a Zink, Alexander $u Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany $1 https://orcid.org/0000000193136588
- 700 1_
- $a Breynaert, Christine $u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group and MASTeL, University Hospitals Leuven, Leuven, Belgium $1 https://orcid.org/0000000273681068
- 700 1_
- $a Leven, Toon $u KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group and MASTeL, University Hospitals Leuven, Leuven, Belgium
- 700 1_
- $a Yavuz, Akif Selim $u Division of Hematology, Istanbul Medical School, University of Istanbul, Istanbul, Turkey
- 700 1_
- $a Doubek, Michael $u Department of Internal Medicine - Hematology and Oncology, University Hospital Brno & Faculty of Medicine, Masaryk University, Brno, Czech Republic
- 700 1_
- $a Sabato, Vito $u Department of Immunology-Allergology-Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerpen, Belgium
- 700 1_
- $a Schug, Tanja $u Department of Dermatology and Venereology, University Hospital Graz, Graz, Austria
- 700 1_
- $a Hartmann, Karin $u Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland $u Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland $1 https://orcid.org/0000000245958226
- 700 1_
- $a Triggiani, Massimo $u Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy $1 https://orcid.org/0000000173182093
- 700 1_
- $a Gotlib, Jason $u Stanford Cancer Institute, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA
- 700 1_
- $a Hermine, Olivier $u French Reference Center for Mastocytosis, Hospital Necker, Assistance Publique Hôpitaux de Paris, Imagine Institute, University Paris Descartes, Paris, France
- 700 1_
- $a Arock, Michel $u French Reference Center for Mastocytosis, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, University Paris Sorbonne, Paris, France
- 700 1_
- $a Kluin-Nelemans, Hanneke C $u Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands $1 https://orcid.org/0000000326179427
- 700 1_
- $a Panse, Jens $u Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany $u Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany $1 https://orcid.org/0000000163163112
- 700 1_
- $a Sperr, Wolfgang R $u Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria $u Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
- 700 1_
- $a Valent, Peter $u Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria $u Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria $1 https://orcid.org/0000000304565095 $7 xx0061768
- 700 1_
- $a Reiter, Andreas $u Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
- 700 1_
- $a Schwaab, Juliana $u Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
- 773 0_
- $w MED00194912 $t Blood advances $x 2473-9537 $g Roč. 8, č. 11 (2024), s. 2890-2900
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38593217 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240725 $b ABA008
- 991 __
- $a 20240905134331 $b ABA008
- 999 __
- $a ok $b bmc $g 2143381 $s 1225399
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 8 $c 11 $d 2890-2900 $e 20240611 $i 2473-9537 $m Blood advances $n Blood Adv $x MED00194912
- LZP __
- $a Pubmed-20240725
