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Technical considerations for isolated limb perfusion: A consensus paper
AJ. Hayes, DJ. Coker, L. Been, VW. Boecxstaens, S. Bonvalot, F. De Cian, L. de la Cruz-Merino, C. Duarte, A. Eggermont, V. Farricha, M. Fiore, D. Grünhagen, R. Grützmann, C. Honoré, J. Jakob, M. Hocevar, W. van Houdt, J. Klauzner, C. Kettelhack,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, směrnice pro lékařskou praxi, přehledy
- MeSH
- chemoterapie nádorů pomocí regionální perfúze * metody MeSH
- delfská metoda MeSH
- končetiny * krevní zásobení MeSH
- konsensus MeSH
- lidé MeSH
- nádory MeSH
- TNF-alfa MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- směrnice pro lékařskou praxi MeSH
BACKGROUND: Isolated limb perfusion (ILP) is a well-established surgical procedure for the administration of high dose chemotherapy to a limb for the treatment of advanced extremity malignancy. Although the technique of ILP was first described over 60 years ago, ILP is utilised in relatively few specialist centres, co-located with tertiary or quaternary cancer centres. The combination of high dose cytotoxic chemotherapy and the cytokine tumour necrosis factor alpha (TNFα), mandates leakage monitoring to prevent potentially serious systemic toxicity. Since the procedure is performed at relatively few specialist centres, an ILP working group was formed with the aim of producing technical consensus guidelines for the procedure to streamline practice and to provide guidance for new centres commencing the technique. METHODS: Between October 2021 and October 2023 a series of face to face online and hybrid meetings were held in which a modified Delphi process was used to develop a unified consensus document. After each meeting the document was modified and recirculated and then rediscussed at subsequent meeting until a greater than 90% consensus was achieved in all recommendations. RESULTS: The completed consensus document comprised 23 topics in which greater than 90% consensus was achieved, with 83% of recommendations having 100% consensus across all members of the working group. The consensus recommendations covered all areas of the surgical procedure including pre-operative assessment, drug dosing and administration, perfusion parameters, hyperthermia, leakage monitoring and theatre logistics, practical surgical strategies and also post-operative care, response evaluation and staff training. CONCLUSION: We present the first joint expert-based consensus statement with respect to the technical aspects of ILP that can serve as a reference point for both existing and new centres in providing ILP.
Belpharma s a Luxembourg Luxembourg
Chairman surgical subgroup EORTC Melanoma Group Brussels Belgium
Clarunis University Center for Gastrointestinal and Liver Disease Basel Basel Switzerland
Department of Academic Surgery Royal Marsden Hospital London UK
Department of Cardiovascular Surgery Clinica University of Navarra Pamplona Spain
Department of Surgery Institute Curie Paris France
Department of Surgery Oncology and Gastroenterology DISCOG University of Padua Padua Italy
Department of Surgery Royal Prince Alfred Hospital Sydney Australia
Department of Surgery Veneto Institute of Oncology IOV IRCCS Padua Italy
Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Rotterdam the Netherlands
Department of Surgical Oncology Instituto Nacional de Cancerología Bogota Colombia
Department of Surgical Oncology University Hospitals Leuven Belgium
Deputy Direction of Surgical Oncology Instituto Nacional de Cancerología Mexico
Direttore divisione dermatologia Oncologica Image Institute Milan Italy
Emeritus Professor of Surgical Oncology University of Crete Greece
Institut Bergonié Sarcoma Unit '229 cours de l'Argonne 33000 Bordeaux France
Institute of Cancer Research London UK
Institute of Oncology Ljubljana Slovenia
Instituto Português De Oncologia De Porto 4200 Porto Portugal
IRCSS Istituto Europeo di Oncologia Milan Italy
Italy Clinical Oncology Department Italy
Melanoma and Sarcoma Unit Department of Surgery Portuguese Institute of Oncology Lisbon Portugal
Peter MacCallum Cancer Centre Victoria Australia
Policlinico San Martino University of Genoa Genoa Italy Clinical Oncology Department
Sarcoma Service Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy
Sir Peter MacCallum Department of Oncology University of Melbourne Victoria Australia
The University of Sydney Sydney Australia
University Hospital Virgen Macarena Seville Spain
University Medical Center Utrecht and Princess Maxima Center Utrecht the Netherlands
Citace poskytuje Crossref.org
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