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Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis

RJ. Fox, BAC. Cree, J. de Sèze, R. Gold, HP. Hartung, D. Jeffery, L. Kappos, X. Montalban, B. Weinstock-Guttman, CM. Singh, A. Altincatal, N. Belviso, RL. Avila, PR. Ho, R. Su, R. Engle, D. Sangurdekar, C. de Moor, E. Fisher, BC. Kieseier, RA. Rudick

Fox, Robert J
Autor Fox, Robert J ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Cree, Bruce A C
Autor Cree, Bruce A C ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
de Sèze, Jérôme
Autor de Sèze, Jérôme ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Gold, Ralf
Autor Gold, Ralf ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Hartung, Hans-Peter
Autor Autorita ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Jeffery, Douglas
Autor Jeffery, Douglas From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Kappos, Ludwig
Autor Autorita ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Montalban, Xavier
Autor Montalban, Xavier ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Weinstock-Guttman, Bianca
Autor Weinstock-Guttman, Bianca ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Singh, Carol M
Autor Singh, Carol M From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Altincatal, Arman
Autor Altincatal, Arman ORCID From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Belviso, Nicholas
Autor Belviso, Nicholas From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Avila, Robin L
Autor Avila, Robin L From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Ho, Pei-Ran
Autor Ho, Pei-Ran From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Su, Ray
Autor Su, Ray From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Engle, Robert
Autor Engle, Robert From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Sangurdekar, Dipen
Autor Sangurdekar, Dipen From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
de Moor, Carl
Autor de Moor, Carl From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Fisher, Elizabeth
Autor Fisher, Elizabeth From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Kieseier, Bernd C
Autor Kieseier, Bernd C From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA
Rudick, Richard A
Autor Rudick, Richard A From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany Brain and Mind Center, University of Sydney, Australia Department of Neurology, Palacky University Olomouc, Czech Republic Piedmont HealthCare (D.J.), Mooresville, NC Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.) Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland Vall d'Hebron University Hospital (X.M.), Barcelona, Spain Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

Neurology. 2024 ; 102 (9) : e209357. [pub] 20240422

ISSN 1526-632X
Medvik
Zdroj

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, randomizované kontrolované studie, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/bmc24013943

PubMed 38648580
DOI 10.1212/wnl.0000000000209357
Knihovny.cz E-zdroje

BACKGROUND AND OBJECTIVES: Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We evaluated the relationship between sNfL levels and radiologic MS disease activity through monthly assessments during the 24-week natalizumab treatment interruption period in RESTORE (NCT01071083). METHODS: In the RESTORE trial, participants with relapsing forms of MS who had received natalizumab for ≥12 months were randomized to either continue or stop natalizumab and followed with MRI and blood draws every 4 weeks to week 28 and again at week 52 The sNfL was measured, and its dynamics were correlated with the development of gadolinium-enhancing (Gd+) lesions. Log-linear trend in sNfL levels were modeled longitudinally using generalized estimating equations with robust variance estimator from baseline to week 28. RESULTS: Of 175 patients enrolled in RESTORE, 166 had serum samples for analysis. Participants with Gd+ lesions were younger (37.7 vs 43.1, p = 0.001) and had lower Expanded Disability Status Scale scores at baseline (2.7 vs 3.4, p = 0.017) than participants without Gd+ lesions. sNfL levels increased in participants with Gd+ lesions (n = 65) compared with those without (n = 101, mean change from baseline to maximum sNfL value, 12.1 vs 3.2 pg/mL, respectively; p = 0.003). As the number of Gd+ lesions increased, peak median sNfL change also increased by 1.4, 3.0, 4.3, and 19.6 pg/mL in the Gd+ lesion groups of 1 (n = 12), 2-3 (n = 18), 4-9 (n = 21), and ≥10 (n = 14) lesions, respectively. However, 46 of 65 (71%) participants with Gd+ lesions did not increase above the 95th percentile threshold of the group without Gd+ lesions. The initial increase of sNfL typically trailed the first observation of Gd+ lesions, and the peak increase in sNfL was a median [interquartile range] of 8 [0, 12] weeks after the first appearance of the Gd+ lesion. DISCUSSION: Although sNfL correlated with the presence of Gd+ lesions, most participants with Gd+ lesions did not have elevations in sNfL levels. These observations have implications for the use and interpretation of sNfL as a biomarker for monitoring MS disease activity in controlled trials and clinical practice.

Biogen Cambridge MA

Brain and Mind Center University of Sydney Australia

Department of Neurology Heinrich Heine University Düsseldorf Germany

Department of Neurology Hôpital Civil Strasbourg France

Department of Neurology Palacky University Olomouc Czech Republic

Department of Neurology St Josef Hospital Ruhr University Bochum Germany

Department of Neurology Weill Institute for Neurosciences University of California San Francisco

Departments of Head Spine and Neuromedicine Clinical Research and Biomedical Engineering University Hospital and University of Basel Switzerland

From the Mellen Center for Multiple Sclerosis Neurological Institute Cleveland Clinic OH

Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence Jacobs School of Medicine and Biomedical Sciences Buffalo NY

Piedmont HealthCare Mooresville NC

Research Center for Clinical Neuroimmunology and Neuroscience and MS Center

Vall d'Hebron University Hospital Barcelona Spain

Citace poskytuje Crossref.org

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024 7_: $a 10.1212/WNL.0000000000209357 $2 doi

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100 1_: $a Fox, Robert J $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000242633717

245 10: $a Temporal Relationship Between Serum Neurofilament Light Chain and Radiologic Disease Activity in Patients With Multiple Sclerosis / $c RJ. Fox, BAC. Cree, J. de Sèze, R. Gold, HP. Hartung, D. Jeffery, L. Kappos, X. Montalban, B. Weinstock-Guttman, CM. Singh, A. Altincatal, N. Belviso, RL. Avila, PR. Ho, R. Su, R. Engle, D. Sangurdekar, C. de Moor, E. Fisher, BC. Kieseier, RA. Rudick

520 9_: $a BACKGROUND AND OBJECTIVES: Serum neurofilament light chain (sNfL) levels correlate with multiple sclerosis (MS) disease activity, but the dynamics of this correlation are unknown. We evaluated the relationship between sNfL levels and radiologic MS disease activity through monthly assessments during the 24-week natalizumab treatment interruption period in RESTORE (NCT01071083). METHODS: In the RESTORE trial, participants with relapsing forms of MS who had received natalizumab for ≥12 months were randomized to either continue or stop natalizumab and followed with MRI and blood draws every 4 weeks to week 28 and again at week 52 The sNfL was measured, and its dynamics were correlated with the development of gadolinium-enhancing (Gd+) lesions. Log-linear trend in sNfL levels were modeled longitudinally using generalized estimating equations with robust variance estimator from baseline to week 28. RESULTS: Of 175 patients enrolled in RESTORE, 166 had serum samples for analysis. Participants with Gd+ lesions were younger (37.7 vs 43.1, p = 0.001) and had lower Expanded Disability Status Scale scores at baseline (2.7 vs 3.4, p = 0.017) than participants without Gd+ lesions. sNfL levels increased in participants with Gd+ lesions (n = 65) compared with those without (n = 101, mean change from baseline to maximum sNfL value, 12.1 vs 3.2 pg/mL, respectively; p = 0.003). As the number of Gd+ lesions increased, peak median sNfL change also increased by 1.4, 3.0, 4.3, and 19.6 pg/mL in the Gd+ lesion groups of 1 (n = 12), 2-3 (n = 18), 4-9 (n = 21), and ≥10 (n = 14) lesions, respectively. However, 46 of 65 (71%) participants with Gd+ lesions did not increase above the 95th percentile threshold of the group without Gd+ lesions. The initial increase of sNfL typically trailed the first observation of Gd+ lesions, and the peak increase in sNfL was a median [interquartile range] of 8 [0, 12] weeks after the first appearance of the Gd+ lesion. DISCUSSION: Although sNfL correlated with the presence of Gd+ lesions, most participants with Gd+ lesions did not have elevations in sNfL levels. These observations have implications for the use and interpretation of sNfL as a biomarker for monitoring MS disease activity in controlled trials and clinical practice.

650 _2: $a lidé $7 D006801

650 12: $a neurofilamentové proteiny $x krev $7 D016900

650 _2: $a ženské pohlaví $7 D005260

650 _2: $a mužské pohlaví $7 D008297

650 _2: $a dospělí $7 D000328

650 _2: $a lidé středního věku $7 D008875

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650 _2: $a imunologické faktory $x terapeutické užití $x krev $7 D007155

650 _2: $a roztroušená skleróza $x krev $x diagnostické zobrazování $x farmakoterapie $7 D009103

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655 _2: $a randomizované kontrolované studie $7 D016449

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700 1_: $a Cree, Bruce A C $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000176892533

700 1_: $a de Sèze, Jérôme $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000271977578

700 1_: $a Gold, Ralf $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000272233052

700 1_: $a Hartung, Hans-Peter $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000206146989 $7 nlk20050167624

700 1_: $a Jeffery, Douglas $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Kappos, Ludwig $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000341755509 $7 xx0060839

700 1_: $a Montalban, Xavier $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0000000200989918

700 1_: $a Weinstock-Guttman, Bianca $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/000000016732151X

700 1_: $a Singh, Carol M $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Altincatal, Arman $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA $1 https://orcid.org/0009000366666227

700 1_: $a Belviso, Nicholas $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Avila, Robin L $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Ho, Pei-Ran $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Su, Ray $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Engle, Robert $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Sangurdekar, Dipen $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a de Moor, Carl $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Fisher, Elizabeth $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Kieseier, Bernd C $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

700 1_: $a Rudick, Richard A $u From the Mellen Center for Multiple Sclerosis (R.J.F.), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (B.A.C.C.), Weill Institute for Neurosciences, University of California San Francisco; Department of Neurology (J.S.), Hôpital Civil, Strasbourg, France; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (H.-P.H.), Heinrich Heine University, Düsseldorf, Germany; Brain and Mind Center, University of Sydney, Australia; Department of Neurology, Palacky University Olomouc, Czech Republic; Piedmont HealthCare (D.J.), Mooresville, NC; Research Center for Clinical Neuroimmunology and Neuroscience and MS Center (L.K.); Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Vall d'Hebron University Hospital (X.M.), Barcelona, Spain; Jacobs Multiple Sclerosis Center and Pediatric Multiple Sclerosis Center of Excellence (B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; and Biogen (C.M.S., A.A., N.B., R.L.A., P.-R.H., R.S., R.E., D.S., C.M., E.F., B.C.K., R.A.R.), Cambridge, MA

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