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Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology
F. Roth-Walter, IM. Adcock, C. Benito-Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, KF. Chung, Z. Diamant, I. Eguiluz-Gracia, EF. Knol, M. Jesenak, F. Levi-Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M....
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
Grantová podpora
Aimwell Charitable Trust
Austrian Science Fund FWF project SFB F4606-B28
Danube Allergy Research Cluster-DARC #08
Emalie Gutterman Memorial Endowed Fund
EPSRC (EP/T003189/1)
European Academy for Allergy and Clinical Immunology
Instituto de Salud Carlos III of the Spanish Ministry of Economy and Competitiveness
Israel Science Foundation
MICIIN (PID2020-114396RB-I00)
Ministero dell'Istruzione, dell'Università e della Ricerca
MRC (MR/T010371/1)
Novartis
Stiftung vorm. Bündner Heilstätte Arosa
Swiss National Science Foundation (SNSF nr 310030_189334/1)
University of Messina, Sicilia Region
University of Salerno and Campania Region
PubMed
38108546
DOI
10.1111/all.15977
Knihovny.cz E-zdroje
- MeSH
- chronická nemoc MeSH
- chronická obstrukční plicní nemoc metabolismus farmakoterapie imunologie MeSH
- lidé MeSH
- metabolické sítě a dráhy * MeSH
- plicní nemoci etiologie farmakoterapie metabolismus imunologie MeSH
- stárnutí buněk * účinky léků MeSH
- stárnutí imunologie metabolismus MeSH
- zánět metabolismus imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation. Metabolic changes imposed by environmental stress and inflammation on immune cells and tissue microenvironment are thus chiefly involved in the pathophysiology of allergic and other immune-driven diseases. Altered cell metabolism is also a hallmark of cell senescence, a condition characterized by loss of proliferative activity in cells that remain metabolically active. Accelerated senescence can be triggered by acute or chronic stress and inflammatory responses. In contrast, replicative senescence occurs as part of the physiological aging process and has protective roles in cancer surveillance and wound healing. Importantly, cell senescence can also change or hamper response to diverse therapeutic treatments. Understanding the metabolic pathways of senescence in immune and structural cells is therefore critical to detect, prevent, or revert detrimental aspects of senescence-related immunopathology, by developing specific diagnostics and targeted therapies. In this paper, we review the main changes and metabolic alterations occurring in senescent immune cells (macrophages, B cells, T cells). Subsequently, we present the metabolic footprints described in translational studies in patients with chronic asthma and chronic obstructive pulmonary disease (COPD), and review the ongoing preclinical studies and clinical trials of therapeutic approaches aiming at targeting metabolic pathways to antagonize pathological senescence. Because this is a recently emerging field in allergy and clinical immunology, a better understanding of the metabolic profile of the complex landscape of cell senescence is needed. The progress achieved so far is already providing opportunities for new therapies, as well as for strategies aimed at disease prevention and supporting healthy aging.
APC Microbiome Ireland University College Cork Cork Ireland
Christine Kühne Center for Allergy Research and Education Davos Switzerland
Department of Medicine and Surgery University of Parma Pneumologia Italy
Department of Medicine Section of Pharmacology University of Perugia Perugia Italy
Department of Medicine University College Cork Cork Ireland
Molecular Cell Biology Group National Heart and Lung Institute Imperial College London London UK
School of Microbiology University College Cork Cork Ireland
Swiss Institute of Allergy and Asthma Research University of Zürich Davos Switzerland
Citace poskytuje Crossref.org
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