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Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis
O. Bin-Alamer, H. Abou-Al-Shaar, R. Singh, AN. Mallela, A. Legarreta, G. Bowden, D. Mathieu, HK. Perlow, JD. Palmer, S. Elhamdani, M. Shepard, Y. Liang, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdelkarim, AMN. El-Shehaby, R. Emad Eldin, AH....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie
PubMed
37948682
DOI
10.3171/2023.8.jns231231
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- kolorektální nádory * patologie mortalita MeSH
- lidé středního věku MeSH
- lidé MeSH
- míra přežití MeSH
- nádory mozku * sekundární radioterapie mortalita chirurgie MeSH
- radiochirurgie * škodlivé účinky MeSH
- retrospektivní studie MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVE: The goal of this study was to characterize local tumor control (LC), overall survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM). METHODS: Ten international institutions participating in the International Radiosurgery Research Foundation provided data for this retrospective case series. This study included 187 patients with CRBM (281 tumors), with a median age of 62 years and 56.7% being male. Most patients (53.5%) had solitary tumors, although 10.7% had > 5 tumors. The median tumor volume was 2.7 cm3 (IQR 0.22-8.1 cm3), and the median margin dose was 20 Gy (IQR 18-22 Gy). RESULTS: The 3-year LC and OS rates were 72% and 20%, respectively. Symptomatic adverse radiation effects occurred in 1.6% of patients. In the multivariate analysis, age > 65 years and tumor volume > 4.0 cm3 were significant predictors of tumor progression (hazard ratio [HR] 2.6, 95% CI 1.4-4.9; p = 0.003 and HR 3.4, 95% CI 1.7-6.9; p < 0.001, respectively). Better performance status (Karnofsky Performance Scale score > 80) was associated with a reduced risk of tumor progression (HR 0.38, 95% CI 0.19-0.73; p = 0.004). Patient age > 62 years (HR 1.6, 95% CI 1.1-2.3; p = 0.03) and the presence of active extracranial disease (HR 1.7, 95% CI 1.1-2.4; p = 0.009) were significantly associated with worse OS. CONCLUSIONS: Stereotactic radiosurgery offers a high LC rate and a low rate of symptomatic adverse radiation effects for the majority of CRBMs. The OS and LC favored younger patients with high functional performance scores and inactive extracranial disease.
Ain Shams University Cairo Egypt
Clinical Oncology Ain Shams University Cairo Egypt
Department of Neurological Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania
Department of Neurosurgery Benha University Benha Egypt
Department of Neurosurgery Humanitas Research Hospital IRCCS Milan Italy
Department of Neurosurgery Koc University School of Medicine Istanbul Turkey
Department of Neurosurgery Neurological Institute Taipei Veterans General Hospital Taipei Taiwan
Department of Neurosurgery Université de Sherbrooke Quebec Canada
Department of Neurosurgery University of Alberta Edmonton Alberta Canada
Department of Neurosurgery University of Pennsylvania Philadelphia Pennsylvania
Department of Neurosurgery Yale University School of Medicine New Haven Connecticut
Department of Radiation Oncology Mayo Clinic Florida Jacksonville Florida
Department of Radiation Oncology National Cancer Institute Cairo University Cairo Egypt
Department of Radiation Oncology Virginia Commonwealth University Health System Richmond Virginia
Department of Stereotactic and Radiation Neurosurgery Na Homolce Hospital Prague Czech Republic
Departments of11Neurosurgery and
Departments of22Neurological Surgery and
Departments of5Radiation Oncology and
Departments of7Neurosurgery and
Gamma Knife Center Jewish Hospital Mayfield Clinic Cincinnati Ohio
Gamma Knife Center Nasser Institute Hospital Cairo Egypt
National Yang Ming Chiao Tung University School of Medicine Hsinchu Taiwan
Radiation Oncology Allegheny Health Network Pittsburgh Pennsylvania
Radiation Oncology University of Virginia Charlottesville Virginia
Citace poskytuje Crossref.org
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- $a Bin-Alamer, Othman $u 1Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
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- $a Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis / $c O. Bin-Alamer, H. Abou-Al-Shaar, R. Singh, AN. Mallela, A. Legarreta, G. Bowden, D. Mathieu, HK. Perlow, JD. Palmer, S. Elhamdani, M. Shepard, Y. Liang, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdelkarim, AMN. El-Shehaby, R. Emad Eldin, AH. Elazzazi, RE. Warnick, YM. Gozal, M. Daly, B. McShane, M. Addis-Jackson, G. Karthikeyan, S. Smith, P. Picozzi, A. Franzini, T. Kaisman-Elbaz, HC. Yang, J. Hess, K. Templeton, X. Zhang, Z. Wei, S. Pikis, G. Mantziaris, G. Simonova, R. Liscak, S. Peker, Y. Samanci, V. Chiang, CR. Kersh, CC. Lee, DM. Trifiletti, A. Niranjan, CG. Hadjipanayis, LD. Lunsford, JP. Sheehan
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- $a OBJECTIVE: The goal of this study was to characterize local tumor control (LC), overall survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM). METHODS: Ten international institutions participating in the International Radiosurgery Research Foundation provided data for this retrospective case series. This study included 187 patients with CRBM (281 tumors), with a median age of 62 years and 56.7% being male. Most patients (53.5%) had solitary tumors, although 10.7% had > 5 tumors. The median tumor volume was 2.7 cm3 (IQR 0.22-8.1 cm3), and the median margin dose was 20 Gy (IQR 18-22 Gy). RESULTS: The 3-year LC and OS rates were 72% and 20%, respectively. Symptomatic adverse radiation effects occurred in 1.6% of patients. In the multivariate analysis, age > 65 years and tumor volume > 4.0 cm3 were significant predictors of tumor progression (hazard ratio [HR] 2.6, 95% CI 1.4-4.9; p = 0.003 and HR 3.4, 95% CI 1.7-6.9; p < 0.001, respectively). Better performance status (Karnofsky Performance Scale score > 80) was associated with a reduced risk of tumor progression (HR 0.38, 95% CI 0.19-0.73; p = 0.004). Patient age > 62 years (HR 1.6, 95% CI 1.1-2.3; p = 0.03) and the presence of active extracranial disease (HR 1.7, 95% CI 1.1-2.4; p = 0.009) were significantly associated with worse OS. CONCLUSIONS: Stereotactic radiosurgery offers a high LC rate and a low rate of symptomatic adverse radiation effects for the majority of CRBMs. The OS and LC favored younger patients with high functional performance scores and inactive extracranial disease.
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