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Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

N. Basheer, L. Buee, JP. Brion, T. Smolek, MK. Muhammadi, J. Hritz, T. Hromadka, I. Dewachter, S. Wegmann, I. Landrieu, P. Novak, A. Mudher, N. Zilka

. 2024 ; 12 (1) : 52. [pub] 20240404

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu systematický přehled, časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc24014360

Grantová podpora
APVV-20-0447 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
APVV-19-0585 Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
MULTI-MEMO EU Joint Programme - Neurodegenerative Disease Research
2/0127/22 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
873127 HORIZON EUROPE Marie Sklodowska-Curie Actions

The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.

Citace poskytuje Crossref.org

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$a The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotypical spread of tau and reproduce various types of tau inclusions linked to specific tauopathy, albeit with varying degrees of fidelity. With this systematic review, we underscore the significance of judicious selection and meticulous functional, biochemical, and biophysical characterization of various tau inocula. Furthermore, we highlight the necessity of choosing suitable animal models and inoculation sites, along with the critical need for validation of fibrillary pathology using confirmatory staining, to accurately recapitulate disease-specific inclusions. As a practical guide, we put forth a framework for establishing a benchmark of inoculation-based tau propagation models that holds promise for use in preclinical testing of disease-modifying drugs.
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