-
Something wrong with this record ?
A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function
P. Ameri, V. Mercurio, P. Pollesello, MS. Anker, J. Backs, A. Bayes-Genis, BA. Borlaug, D. Burkhoff, S. Caravita, SY. Chan, F. de Man, G. Giannakoulas, A. González, M. Guazzi, PM. Hassoun, AR. Hemnes, C. Maack, B. Madden, V. Melenovsky, OJ....
Language English Country England, Great Britain
Document type Journal Article, Review
Grant support
CVON-2018-29 PHAEDRA-IMPACT
Royal Netherlands Academy of Sciences
R01 HL162828
NHLBI NIH HHS - United States
R01 HL128526
NHLBI NIH HHS - United States
CVON-2012-08 PHAEDRA
Royal Netherlands Academy of Sciences
ERC CoG 101045236
HORIZON Europe ERC
R01 HL162828
NIH HHS - United States
R01 HL122596
NHLBI NIH HHS - United States
394046768
German Research Foundation DFG
W81XWH2210245
United States Department of Defense
759248
European Research Council under the European Union's Horizon 2020 research and innovation programme
U01 HL160226
NIH HHS - United States
German Centre for Cardiovascular Research
Netherlands Organisation for Health Research and Development
Dutch Heart Foundation, Dutch Federation of University Medical Centres
R01 HL128526
NIH HHS - United States
PNRR-MAD-2022-12376632
Italian Ministry of Health
LX22NPO5104
the National Institute for Research of Metabolic and Cardiovascular Diseases
HL 122596
NIH HHS - United States
NWO-VIDI: 917.18.338
The Netherlands Organization for Scientific Research
DISSECT-HF
HORIZON Europe ERC
European Union - Next Generation EU
R01 HL124021
NIH HHS - United States
Netherlands CardioVascular Research Initiative
CVON-2017-10 Dolphin-Genesis
Royal Netherlands Academy of Sciences
RF-2016-02362988
Italian Ministry of Health
2018T059
Dutch Heart Foundation Dekker senior post-doc
18EIA33900027
American Heart Association
CRC1366 C07
German Research Foundation DFG
NU22-02-00161
Ministry of Health of the Czech Republic
U01 HL160226
NHLBI NIH HHS - United States
R01 HL124021
NHLBI NIH HHS - United States
NLK
Medline Complete (EBSCOhost)
from 2000-03-01 to 1 year ago
Wiley Free Content
from 1999 to 1 year ago
PubMed
38639017
DOI
10.1002/ejhf.3236
Knihovny.cz E-resources
- MeSH
- Ventricular Function, Right * physiology MeSH
- Humans MeSH
- Hypertension, Pulmonary * physiopathology etiology therapy MeSH
- Pulmonary Circulation * physiology MeSH
- Heart Failure * physiopathology complications therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Pulmonary hypertension (PH) associated with left heart failure (LHF) (PH-LHF) is one of the most common causes of PH. It directly contributes to symptoms and reduced functional capacity and negatively affects right heart function, ultimately leading to a poor prognosis. There are no specific treatments for PH-LHF, despite the high number of drugs tested so far. This scientific document addresses the main knowledge gaps in PH-LHF with emphasis on pathophysiology and clinical trials. Key identified issues include better understanding of the role of pulmonary venous versus arteriolar remodelling, multidimensional phenotyping to recognize patient subgroups positioned to respond to different therapies, and conduct of rigorous pre-clinical studies combining small and large animal models. Advancements in these areas are expected to better inform the design of clinical trials and extend treatment options beyond those effective in pulmonary arterial hypertension. Enrichment strategies, endpoint assessments, and thorough haemodynamic studies, both at rest and during exercise, are proposed to play primary roles to optimize early-stage development of candidate therapies for PH-LHF.
Amsterdam Cardiovascular Sciences Pulmonary Hypertension and Thrombosis Amsterdam The Netherlands
Cardiac Thoracic and Vascular Department IRCCS Ospedale Policlinico San Martino Genoa Italy
Cardiology Division San Paolo University Hospital Milan Italy
Cardiovascular Research Foundation New York NY USA
Center for Basic and Clinical Immunology Research Federico 2 University Naples Italy
Center for Molecular Medicine Cologne Faculty of Medicine University of Cologne Cologne Germany
Comprehensive Heart Failure Center and Medical Clinic 1 University Clinic Würzburg Würzburg Germany
Content and Communication Branded Products Orion Pharma Espoo Finland
Department of Cardiology Hopital Universitaire de Bruxelles Erasme Brussels Belgium
Department of Cardiology Institute for Clinical and Experimental Medicine IKEM Prague Czech Republic
Department of Cardiology Istituto Auxologico Italiano IRCCS Ospedale San Luca Milan Italy
Department of Cardiology University Hospital Mannheim Heidelberg University Mannheim Germany
Department of Cardiovascular Diseases Mayo Clinic Rochester MN USA
Department of Internal Medicine and Cardiology Medical University of Warsaw Warsaw Poland
Department of Internal Medicine University of Genova Genoa Italy
Department of Management Information and Production Engineering University of Bergamo Dalmine Italy
Department of Medicine St Johann in Tirol General Hospital St Johann in Tirol Austria
Division of Cardiology Department of Advanced Biomedical Sciences Federico 2 University Naples Italy
Division of Cardiology Department of Medicine Medical University of South Carolina Charleston SC USA
Division of Cardiology Medical University of Graz Graz Austria
Division of Cardiology Northwestern University Feinberg School of Medicine Chicago IL USA
German Center for Cardiovascular Research Berlin Germany
German Centre for Cardiovascular Research Partner Site Berlin Berlin Germany
Heart Research Institute Sydney Australia
Max Rubner Center Department of Cardiology Charité Universitätsmedizin Berlin Berlin Germany
Program of Cardiovascular Diseases CIMA Universidad de Navarra and IdiSNA Pamplona Spain
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24014395
- 003
- CZ-PrNML
- 005
- 20240905133843.0
- 007
- ta
- 008
- 240725s2024 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1002/ejhf.3236 $2 doi
- 035 __
- $a (PubMed)38639017
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Ameri, Pietro $u Department of Internal Medicine, University of Genova, Genoa, Italy $u Cardiac, Thoracic, and Vascular Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
- 245 12
- $a A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function / $c P. Ameri, V. Mercurio, P. Pollesello, MS. Anker, J. Backs, A. Bayes-Genis, BA. Borlaug, D. Burkhoff, S. Caravita, SY. Chan, F. de Man, G. Giannakoulas, A. González, M. Guazzi, PM. Hassoun, AR. Hemnes, C. Maack, B. Madden, V. Melenovsky, OJ. Müller, Z. Papp, SS. Pullamsetti, PP. Rainer, MM. Redfield, S. Rich, GG. Schiattarella, H. Skaara, K. Stellos, RJ. Tedford, T. Thum, JL. Vachiery, P. van der Meer, S. Van Linthout, P. Pruszczyk, P. Seferovic, AJS. Coats, M. Metra, G. Rosano, S. Rosenkranz, CG. Tocchetti
- 520 9_
- $a Pulmonary hypertension (PH) associated with left heart failure (LHF) (PH-LHF) is one of the most common causes of PH. It directly contributes to symptoms and reduced functional capacity and negatively affects right heart function, ultimately leading to a poor prognosis. There are no specific treatments for PH-LHF, despite the high number of drugs tested so far. This scientific document addresses the main knowledge gaps in PH-LHF with emphasis on pathophysiology and clinical trials. Key identified issues include better understanding of the role of pulmonary venous versus arteriolar remodelling, multidimensional phenotyping to recognize patient subgroups positioned to respond to different therapies, and conduct of rigorous pre-clinical studies combining small and large animal models. Advancements in these areas are expected to better inform the design of clinical trials and extend treatment options beyond those effective in pulmonary arterial hypertension. Enrichment strategies, endpoint assessments, and thorough haemodynamic studies, both at rest and during exercise, are proposed to play primary roles to optimize early-stage development of candidate therapies for PH-LHF.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a srdeční selhání $x patofyziologie $x komplikace $x terapie $7 D006333
- 650 12
- $a plicní hypertenze $x patofyziologie $x etiologie $x terapie $7 D006976
- 650 12
- $a funkce pravé komory srdeční $x fyziologie $7 D016278
- 650 12
- $a plicní oběh $x fyziologie $7 D011652
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Mercurio, Valentina $u Department of Translational Medical Sciences, Interdepartmental Center for Clinical and Translational Research (CIRCET), and Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy
- 700 1_
- $a Pollesello, Piero $u Content and Communication, Branded Products, Orion Pharma, Espoo, Finland
- 700 1_
- $a Anker, Markus S $u Deutsches Herzzentrum der Charité, Klinik für Kardiologie, Angiologie und Intensivmedizin (Campus CBF), German Centre for Cardiovascular Research (DZHK) partner site Berlin, Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, Berlin, Germany
- 700 1_
- $a Backs, Johannes $u Institute of Experimental Cardiology, University Hospital Heidelberg, University of Heidelberg and DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
- 700 1_
- $a Bayes-Genis, Antoni $u Heart Institute, Hospital Universitari Germans Trias i Pujol, CIBERCV, Universitat Autònoma de Barcelona, Barcelona, Spain
- 700 1_
- $a Borlaug, Barry A $u Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA $u Cardiovascular Research Foundation, New York, NY, USA
- 700 1_
- $a Burkhoff, Daniel $u Cardiovascular Research Foundation, New York, NY, USA
- 700 1_
- $a Caravita, Sergio $u Department of Management, Information and Production Engineering, University of Bergamo, Dalmine (BG), Italy $u Department of Cardiology, Istituto Auxologico Italiano IRCCS Ospedale San Luca, Milan, Italy
- 700 1_
- $a Chan, Stephen Y $u Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA
- 700 1_
- $a de Man, Frances $u PHEniX laboratory, Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands $u Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands
- 700 1_
- $a Giannakoulas, George $u First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
- 700 1_
- $a González, Aránzazu $u Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA, Pamplona, Spain $u CIBERCV, Madrid, Spain
- 700 1_
- $a Guazzi, Marco $u University of Milan, Milan, Italy $u Cardiology Division, San Paolo University Hospital, Milan, Italy
- 700 1_
- $a Hassoun, Paul M $u Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
- 700 1_
- $a Hemnes, Anna R $u Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
- 700 1_
- $a Maack, Cristoph $u Comprehensive Heart Failure Center (CHFC) and Medical Clinic I, University Clinic Würzburg, Würzburg, Germany
- 700 1_
- $a Madden, Brendan $u St.Georges Hospital, London, UK
- 700 1_
- $a Melenovsky, Vojtech $u Department of Cardiology, Institute for Clinical and Experimental Medicine - IKEM, Prague, Czech Republic
- 700 1_
- $a Müller, Oliver J $u Department of Internal Medicine V, University Hospital Schleswig-Holstein, and German Centre for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany
- 700 1_
- $a Papp, Zoltan $u Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
- 700 1_
- $a Pullamsetti, Soni Savai $u Department of Internal Medicine and Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany
- 700 1_
- $a Rainer, Peter P $u Division of Cardiology, Medical University of Graz, Graz, Austria $u BioTechMed Graz, Graz, Austria $u Department of Medicine, St. Johann in Tirol General Hospital, St. Johann in Tirol, Austria
- 700 1_
- $a Redfield, Margaret M $u Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
- 700 1_
- $a Rich, Stuart $u Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
- 700 1_
- $a Schiattarella, Gabriele G $u Max-Rubner Center (CMR), Department of Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany $u German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany $u Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany $u Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
- 700 1_
- $a Skaara, Hall $u Pulmonary Hypertension Association Europe, Vienna, Austria
- 700 1_
- $a Stellos, Kostantinos $u Department of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany $u German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung, DZHK), Heidelberg/Mannheim Partner Site, Heidelberg and Mannheim, Germany $u Department of Cardiology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany $u Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
- 700 1_
- $a Tedford, Ryan J $u Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
- 700 1_
- $a Thum, Thomas $u Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany
- 700 1_
- $a Vachiery, Jean Luc $u Department of Cardiology, Hopital Universitaire de Bruxelles Erasme, Brussels, Belgium
- 700 1_
- $a van der Meer, Peter $u Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
- 700 1_
- $a Van Linthout, Sophie $u Berlin Institute of Health (BIH) at Charité, BIH Center for Regenerative Therapies, University of Medicine, Berlin, Germany $u German Center for Cardiovascular Research (DZHK, partner site Berlin), Berlin, Germany
- 700 1_
- $a Pruszczyk, Piotr $u Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland
- 700 1_
- $a Seferovic, Petar $u University of Belgrade Faculty of Medicine, Belgrade University Medical Center, Serbian Academy of Sciences and Arts, Belgrade, Serbia
- 700 1_
- $a Coats, Andrew J S $u Heart Research Institute, Sydney, Australia
- 700 1_
- $a Metra, Marco $u Cardiology. ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Rosano, Giuseppe $u IRCCS San Raffaele, Rome, Italy
- 700 1_
- $a Rosenkranz, Stephan $u Department of Cardiology and Cologne Cardiovascular Research Center (CCRC), Heart Center at the University Hospital Cologne, Cologne, Germany $u Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany
- 700 1_
- $a Tocchetti, Carlo Gabriele $u Department of Translational Medical Sciences, Interdepartmental Center for Clinical and Translational Research (CIRCET), and Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy $u Center for Basic and Clinical Immunology Research (CISI), Federico II University, Naples, Italy
- 773 0_
- $w MED00006634 $t European journal of heart failure $x 1879-0844 $g Roč. 26, č. 4 (2024), s. 707-729
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38639017 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240725 $b ABA008
- 991 __
- $a 20240905133837 $b ABA008
- 999 __
- $a ok $b bmc $g 2143894 $s 1226261
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 26 $c 4 $d 707-729 $e 20240419 $i 1879-0844 $m European journal of heart failure $n Eur J Heart Fail $x MED00006634
- GRA __
- $a CVON-2018-29 PHAEDRA-IMPACT $p Royal Netherlands Academy of Sciences
- GRA __
- $a R01 HL162828 $p NHLBI NIH HHS $2 United States
- GRA __
- $a R01 HL128526 $p NHLBI NIH HHS $2 United States
- GRA __
- $a CVON-2012-08 PHAEDRA $p Royal Netherlands Academy of Sciences
- GRA __
- $a ERC CoG 101045236 $p HORIZON Europe ERC
- GRA __
- $a R01 HL162828 $p NIH HHS $2 United States
- GRA __
- $a R01 HL122596 $p NHLBI NIH HHS $2 United States
- GRA __
- $a 394046768 $p German Research Foundation DFG
- GRA __
- $a W81XWH2210245 $p United States Department of Defense
- GRA __
- $a 759248 $p European Research Council under the European Union's Horizon 2020 research and innovation programme
- GRA __
- $a U01 HL160226 $p NIH HHS $2 United States
- GRA __
- $p German Centre for Cardiovascular Research
- GRA __
- $p Netherlands Organisation for Health Research and Development
- GRA __
- $p Dutch Heart Foundation, Dutch Federation of University Medical Centres
- GRA __
- $a R01 HL128526 $p NIH HHS $2 United States
- GRA __
- $a PNRR-MAD-2022-12376632 $p Italian Ministry of Health
- GRA __
- $a LX22NPO5104 $p the National Institute for Research of Metabolic and Cardiovascular Diseases
- GRA __
- $a HL 122596 $p NIH HHS $2 United States
- GRA __
- $a NWO-VIDI: 917.18.338 $p The Netherlands Organization for Scientific Research
- GRA __
- $a DISSECT-HF $p HORIZON Europe ERC
- GRA __
- $p European Union - Next Generation EU
- GRA __
- $a R01 HL124021 $p NIH HHS $2 United States
- GRA __
- $p Netherlands CardioVascular Research Initiative
- GRA __
- $a CVON-2017-10 Dolphin-Genesis $p Royal Netherlands Academy of Sciences
- GRA __
- $a RF-2016-02362988 $p Italian Ministry of Health
- GRA __
- $a 2018T059 $p Dutch Heart Foundation Dekker senior post-doc
- GRA __
- $a 18EIA33900027 $p American Heart Association
- GRA __
- $a CRC1366 C07 $p German Research Foundation DFG
- GRA __
- $a NU22-02-00161 $p Ministry of Health of the Czech Republic
- GRA __
- $a U01 HL160226 $p NHLBI NIH HHS $2 United States
- GRA __
- $a R01 HL124021 $p NHLBI NIH HHS $2 United States
- LZP __
- $a Pubmed-20240725
