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Overcoming antibiotic resistance: non-thermal plasma and antibiotics combination inhibits important pathogens
E. Vaňková, J. Julák, A. Machková, K. Obrová, A. Klančnik, S. Smole Možina, V. Scholtz
Language English Country United States
Document type Journal Article, Review
Grant support
J4-3088
Slovenian Research and Innovation Agency
NLK
PubMed Central
from 2014
ProQuest Central
from 2015-01-01 to 1 year ago
Open Access Digital Library
from 1996-01-01
Health & Medicine (ProQuest)
from 2015-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2015-01-01 to 1 year ago
Oxford Journals Open Access Collection
from 2013-02-01
- MeSH
- Anti-Bacterial Agents * pharmacology therapeutic use MeSH
- Drug Resistance, Microbial MeSH
- Drug Resistance, Bacterial MeSH
- Biofilms * drug effects MeSH
- Humans MeSH
- Methicillin-Resistant Staphylococcus aureus drug effects MeSH
- Disease Models, Animal MeSH
- Mice MeSH
- Plasma Gases * pharmacology MeSH
- Pseudomonas Infections microbiology drug therapy MeSH
- Pseudomonas aeruginosa drug effects MeSH
- Staphylococcal Infections microbiology drug therapy MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Antibiotic resistance (ATBR) is increasing every year as the overuse of antibiotics (ATBs) and the lack of newly emerging antimicrobial agents lead to an efficient pathogen escape from ATBs action. This trend is alarming and the World Health Organization warned in 2021 that ATBR could become the leading cause of death worldwide by 2050. The development of novel ATBs is not fast enough considering the situation, and alternative strategies are therefore urgently required. One such alternative may be the use of non-thermal plasma (NTP), a well-established antimicrobial agent actively used in a growing number of medical fields. Despite its efficiency, NTP alone is not always sufficient to completely eliminate pathogens. However, NTP combined with ATBs is more potent and evidence has been emerging over the last few years proving this is a robust and highly effective strategy to fight resistant pathogens. This minireview summarizes experimental research addressing the potential of the NTP-ATBs combination, particularly for inhibiting planktonic and biofilm growth and treating infections in mouse models caused by methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa. The published studies highlight this combination as a promising solution to emerging ATBR, and further research is therefore highly desirable.
References provided by Crossref.org
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