Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors

R. Jugas, P. Pokorna, S. Adamcova, K. Kozelkova, D. Knoflickova, H. Palova, J. Sterba, O. Slaby

. 2024 ; 55 (-) : 110590. [pub] 20240607

Status neindexováno Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24018121

Alterations in DNA methylation profiles belong to important mechanisms in cancer development, and their assessment can be utilized for rapid and precise diagnostics. Therefore, establishing datasets of methylation profiles can improve and deepen our understanding of the role of epigenetic changes in cancer development as well as improve our diagnostic capabilities. In this dataset, we generated NGS data for 189 samples of pediatric CNS, soft tissue, and bone tumors. The sequencing libraries were prepared using methyl capture bisulfite sequencing, an effective compromise between whole-genome bisulfite sequencing and array-based methods with a more limited scope of target regions. The larger part of the cohort was processed with the Agilent SureSelectXT Human Methyl-Seq kit (149 samples) and the rest with the Illumina TruSeq Methyl Capture EPIC Library Prep Kit (40 samples). The data presented in this article may help other researchers further elucidate the importance of methylation in diagnosing pediatric CNS tumors, soft tissue, and bone tumors.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24018121
003      
CZ-PrNML
005      
20241016081839.0
007      
ta
008      
241008e20240607ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.dib.2024.110590 $2 doi
035    __
$a (PubMed)38974008
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Jugas, Robin $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia
245    10
$a Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors / $c R. Jugas, P. Pokorna, S. Adamcova, K. Kozelkova, D. Knoflickova, H. Palova, J. Sterba, O. Slaby
520    9_
$a Alterations in DNA methylation profiles belong to important mechanisms in cancer development, and their assessment can be utilized for rapid and precise diagnostics. Therefore, establishing datasets of methylation profiles can improve and deepen our understanding of the role of epigenetic changes in cancer development as well as improve our diagnostic capabilities. In this dataset, we generated NGS data for 189 samples of pediatric CNS, soft tissue, and bone tumors. The sequencing libraries were prepared using methyl capture bisulfite sequencing, an effective compromise between whole-genome bisulfite sequencing and array-based methods with a more limited scope of target regions. The larger part of the cohort was processed with the Agilent SureSelectXT Human Methyl-Seq kit (149 samples) and the rest with the Illumina TruSeq Methyl Capture EPIC Library Prep Kit (40 samples). The data presented in this article may help other researchers further elucidate the importance of methylation in diagnosing pediatric CNS tumors, soft tissue, and bone tumors.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Pokorna, Petra $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia $u Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia
700    1_
$a Adamcova, Sona $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia
700    1_
$a Kozelkova, Katerina $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia
700    1_
$a Knoflickova, Dana $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia $u Department of Oncological Pathology, Masaryk Memorial Cancer Institute, Žlutý kopec 543/7, 656 53 Brno, Czechia
700    1_
$a Palova, Hana $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia
700    1_
$a Sterba, Jaroslav $u Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00 Brno, Czechia
700    1_
$a Slaby, Ondrej $u Department of Biology, Faculty of Medicine and Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czechia
773    0_
$w MED00188041 $t Data in brief $x 2352-3409 $g Roč. 55 (20240607), s. 110590
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38974008 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20241008 $b ABA008
991    __
$a 20241016081835 $b ABA008
999    __
$a ok $b bmc $g 2196465 $s 1230072
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2024 $b 55 $c - $d 110590 $e 20240607 $i 2352-3409 $m Data in brief $n Data Brief $x MED00188041
LZP    __
$a Pubmed-20241008

Najít záznam

Citační ukazatele

Možnosti archivace