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Assessing spatial distribution of bioindicator elements in various cutaneous tumors using correlative imaging with laser-ablation-based analytical methods

K. Kiss, H. Kopřivová, V. Stejskal, L. Krbal, J. Buday, L. Brunnbauer, E. Képeš, P. Pořízka, A. Ryška, M. Kaška, J. Kaiser, A. Limbeck

. 2024 ; 279 (-) : 126651. [pub] 20240805

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24018678

Correlative imaging of cutaneous tumors provides additional information to the standard histopathologic examination. However, the joint progress in the establishment of analytical techniques, such as Laser-Induced Breakdown Spectroscopy (LIBS) and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) in clinical practice is still limited. Their combination provides complementary information as it is also shown in our study in terms of major biotic (Ca, Mg, and P) and trace (Cu and Zn) elements. To elucidate changes in the elemental composition in tumors, we have compiled a set of malignant tumors (Squamous Cell Carcinoma, Basal Cell Carcinoma, Malignant Melanoma, and Epithelioid Angiosarcoma), one benign tumor (Pigmented Nevus) and one healthy-skin sample. The data processing was based on a methodological pipeline involving binary image registration and affine transformation. Thus, our paper brings a feasibility study of a practical methodological concept that enables us to compare LIBS and LA-ICP-MS results despite the mutual spatial distortion of original elemental images. Moreover, we also show that LIBS could be a sufficient pre-screening method even for a larger number of samples according to the speed and reproducibility of the analyses. Whereas LA-ICP-MS could serve as a ground truth and reference technique for preselected samples.

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$a Kiss, Kateřina $u Charles University, Faculty of Medicine in Hradec Králové, Academic Department of Surgery, Šimkova 870, 500 03 Hradec Králové, Czech Republic; Charles University, Third Faculty of Medicine, Department of Plastic Surgery, Ruská 2411, 100 00 Praha 10, Czech Republic; Surgical Department, Faculty of Medicine in Hradec Králové Charles University and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic
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$a Assessing spatial distribution of bioindicator elements in various cutaneous tumors using correlative imaging with laser-ablation-based analytical methods / $c K. Kiss, H. Kopřivová, V. Stejskal, L. Krbal, J. Buday, L. Brunnbauer, E. Képeš, P. Pořízka, A. Ryška, M. Kaška, J. Kaiser, A. Limbeck
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$a Correlative imaging of cutaneous tumors provides additional information to the standard histopathologic examination. However, the joint progress in the establishment of analytical techniques, such as Laser-Induced Breakdown Spectroscopy (LIBS) and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) in clinical practice is still limited. Their combination provides complementary information as it is also shown in our study in terms of major biotic (Ca, Mg, and P) and trace (Cu and Zn) elements. To elucidate changes in the elemental composition in tumors, we have compiled a set of malignant tumors (Squamous Cell Carcinoma, Basal Cell Carcinoma, Malignant Melanoma, and Epithelioid Angiosarcoma), one benign tumor (Pigmented Nevus) and one healthy-skin sample. The data processing was based on a methodological pipeline involving binary image registration and affine transformation. Thus, our paper brings a feasibility study of a practical methodological concept that enables us to compare LIBS and LA-ICP-MS results despite the mutual spatial distortion of original elemental images. Moreover, we also show that LIBS could be a sufficient pre-screening method even for a larger number of samples according to the speed and reproducibility of the analyses. Whereas LA-ICP-MS could serve as a ground truth and reference technique for preselected samples.
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$a Kopřivová, Hana $u Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00 Brno, Czech Republic
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$a Stejskal, Václav $u Charles University, Faculty of Medicine in Hradec Králové, Academic Department of Surgery, Šimkova 870, 500 03 Hradec Králové, Czech Republic; The Fingerland Department of Pathology, Faculty of Medicine in Hradec Králové Charles University and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic
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$a Krbal, Lukáš $u Charles University, Faculty of Medicine in Hradec Králové, Academic Department of Surgery, Šimkova 870, 500 03 Hradec Králové, Czech Republic; The Fingerland Department of Pathology, Faculty of Medicine in Hradec Králové Charles University and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic
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$a Buday, Jakub $u Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00 Brno, Czech Republic; Faculty of Mechanical Engineering (FME), Brno University of Technology, Technická 2 896, 616 69 Brno, Czech Republic
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$a Brunnbauer, Lukas $u TU Wien, Institute of Chemical Technologies and Analytics, Getreidemarkt 9/164-I(2)AC, 1060 Vienna, Austria
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$a Képeš, Erik $u Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00 Brno, Czech Republic
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$a Pořízka, Pavel $u Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00 Brno, Czech Republic; Faculty of Mechanical Engineering (FME), Brno University of Technology, Technická 2 896, 616 69 Brno, Czech Republic. Electronic address: pavel.porizka@ceitec.vutbr.cz
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$a Ryška, Aleš $u The Fingerland Department of Pathology, Faculty of Medicine in Hradec Králové Charles University and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic
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$a Kaška, Milan $u Charles University, Faculty of Medicine in Hradec Králové, Academic Department of Surgery, Šimkova 870, 500 03 Hradec Králové, Czech Republic; Surgical Department, Faculty of Medicine in Hradec Králové Charles University and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic
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$a Kaiser, Jozef $u Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00 Brno, Czech Republic; Faculty of Mechanical Engineering (FME), Brno University of Technology, Technická 2 896, 616 69 Brno, Czech Republic
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$a Limbeck, Andreas $u TU Wien, Institute of Chemical Technologies and Analytics, Getreidemarkt 9/164-I(2)AC, 1060 Vienna, Austria
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