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Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk
C. Corradi, G. Lencioni, A. Felici, C. Rizzato, M. Gentiluomo, S. Ermini, L. Archibugi, A. Mickevicius, M. Lucchesi, E. Malecka-Wojciesko, D. Basso, PG. Arcidiacono, MC. Petrone, S. Carrara, M. Götz, S. Bunduc, B. Holleczek, MN. Aoki, FG....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
Fondazione Arpa
Intramural funding of German Cancer Research Center (DKFZ)
Fondazione Tizzi
FIMP_ CUP J37G22000230001
Ministero della Salute
Ricerca Corrente 2022-2024
Ministero della Salute
2021-26201
Associazione Italiana per la Ricerca sul Cancro, AIRC IG
26343
Associazione Italiana per la Ricerca sul Cancro, AIRC IG
NU21-03-00499
Ministry of Health Czech Republic
5x1000 voluntary contribution
PubMed
38924078
DOI
10.1002/ijc.35046
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- antigeny nádorové * genetika MeSH
- Asijci genetika MeSH
- běloši genetika MeSH
- duktální karcinom slinivky břišní * genetika MeSH
- genetická predispozice k nemoci * MeSH
- GPI-vázané proteiny * genetika MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokus kvantitativního znaku MeSH
- metylace DNA * MeSH
- nádorové proteiny * genetika MeSH
- nádory slinivky břišní * genetika MeSH
- studie případů a kontrol MeSH
- vazebná nerovnováha * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10-5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer; however, functional studies are needed to elucidate the function relevance of the association.
ARC NET Centre for Applied Research on Cancer University and Hospital Trust of Verona Verona Italy
Blood Transfusion Service Azienda Ospedaliera Universitaria Meyer Children's Hospital Florence Italy
Carol Davila University of Medicine and Pharmacy Bucharest Romania
Center for Translational Medicine Semmelweis University Budapest Hungary
Clinics of Institute of Endocrinology Lithuanian University of Health Sciences Kaunas Lithuania
Department of Biology University of Pisa Pisa Italy
Department of Digestive Tract Diseases Medical University of Lodz Lodz Poland
Department of DiSCOG University of Padova Padua Italy
Department of General Surgery University of Heidelberg Heidelberg Germany
Department of Surgery Erasmus MC University Medical Center Rotterdam The Netherlands
Department of Surgery Lithuanian University of Health Sciences Kaunas Lithuania
Digestive and Liver Disease Unit Sant'Andrea Hospital Rome Italy
Digestive Diseases and Liver Transplantation Center Fundeni Clinical Institute Bucharest Romania
Division of General and Transplant Surgery Pisa University Hospital Pisa Italy
Division of Pancreatic Diseases Heart and Vascular Center Semmelweis University Budapest Hungary
Division of Preventive Oncology German Cancer Research Center Heidelberg Germany
Endoscoopic Unit Gastroenterology Department IRCCS Humanitas Research Hospital Rozzano Milan Italy
Faculty of Medicine and Dentistry Palacky University Olomouc Olomouc Czech Republic
Faculty of Medicine in Pilsen Biomedical Center Charles University Pilsen Czech Republic
Genomic Epidemiology Group German Cancer Research Center Heidelberg Germany
German Cancer Consortium Heidelberg Germany
Humanitas University Rozzano Milan Italy
Institute for Translational Medicine Medical School University of Pécs Pécs Hungary
János Szentágothai Research Center University of Pécs Pécs Hungary
Laboratory Medicine Department DIMED University of Padova Padua Italy
Oncology of Massa Carrara Oncological Department Azienda USL Toscana Nord Ovest Carrara Italy
Pancreatic Surgery Department IRCCS Humanitas Research Hospital Rozzano Milan Italy
Potenza County Medical Association Potenza Italy
Citace poskytuje Crossref.org
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