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RNAs in tumour-derived extracellular vesicles and their significance in the tumour microenvironment

M. Bugajova, M. Raudenska, M. Masarik, D. Kalfert, J. Betka, J. Balvan

. 2024 ; 155 (7) : 1147-1161. [pub] 20240606

Language English Country United States

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc24018813

Grant support
NU20J-08-00018 Ministry of Health of the Czech Republic
GACR - 21-06873S Grant Agency of the Czech Republic
MUNI/A/1370/2022 Ministry of Education, Youth and Sports of the Czech Republic
MUNI/A/1343/2022 Ministry of Education, Youth and Sports of the Czech Republic

Small extracellular vesicles (sEVs) secreted by various types of cells serve as crucial mediators of intercellular communication within the complex tumour microenvironment (TME). Tumour-derived small extracellular vesicles (TDEs) are massively produced and released by tumour cells, recapitulating the specificity of their cell of origin. TDEs encapsulate a variety of RNA species, especially messenger RNAs, microRNAs, long non-coding RNAs, and circular RNAs, which release to the TME plays multifaced roles in cancer progression through mediating cell proliferation, invasion, angiogenesis, and immune evasion. sEVs act as natural delivery vehicles of RNAs and can serve as useful targets for cancer therapy. This review article provides an overview of recent studies on TDEs and their RNA cargo, with emphasis on the role of these RNAs in carcinogenesis.

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