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Dynamics and necessity of SIRT1 for maternal-zygotic transition

J. Nevoral, D. Drutovic, M. Vaskovicova, M. Benc, F. Liska, I. Valentova, S. Stachovicova, J. Kubovciak, J. Havrankova, M. Shavit, L. Monsef, M. Iniesta-Cuerda, T. Zalmanova, P. Hosek, F. Strejcek, M. Kralickova, J. Petr

. 2024 ; 14 (1) : 21598. [pub] 20240916

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24018898

Grantová podpora
MED/DIAG Ministerstvo Školství, Mládeže a Tělovýchovy
SVV 260 651 Ministerstvo Školství, Mládeže a Tělovýchovy,Czechia
QL24010123 Technologická Agentura České Republiky
23-07532S Grantová Agentura České Republiky
DS-FR-22-0003 Agentúra na Podporu Výskumu a Vývoja
MZE-RO0723 Ministerstvo Zemědělství
00064165 Ministerstvo Zdravotnictví Ceské Republiky

Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action.

Citace poskytuje Crossref.org

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