-
Something wrong with this record ?
Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle
N. Aldweib, P. Deghani, CS. Broberg, A. van Dissel, A. Altibi, J. Wong, D. Baker, S. Gindi, P. Khairy, AR. Opotowsky, S. Shah, A. Magalski, J. Cramer, RM. Kauling, M. Dellborg, EV. Krieger, E. Yeung, J. Roos-Hesselink, J. Aboulhosn, J....
Language English Country United States
Document type Journal Article, Multicenter Study
Grant support
0885045N
American Heart Association-American Stroke Association - United States
UL1 TR002369
NCATS NIH HHS - United States
NLK
Free Medical Journals
from 2008 to 1 year ago
Open Access Digital Library
from 2008-05-01
- MeSH
- Adult MeSH
- Ventricular Function, Right physiology MeSH
- Hemodynamics * physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Pulmonary Wedge Pressure physiology MeSH
- Prognosis MeSH
- Retrospective Studies MeSH
- Cardiac Catheterization * MeSH
- Heart Ventricles * physiopathology diagnostic imaging MeSH
- Transposition of Great Vessels * physiopathology surgery MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
BACKGROUND: Patients with transposition of the great arteries (TGA) and systemic right ventricle often confront significant adverse cardiac events. The prognostic significance of invasive hemodynamic parameters in this context remains uncertain. Our hypothesis is that the aortic pulsatility index and hemodynamic profiling utilizing invasive measures provide prognostic insights for patients with TGA and a systemic right ventricle. METHODS: This retrospective multicenter cohort study encompasses adults with TGA and a systemic right ventricle who underwent cardiac catheterization. Data collection, spanning from 1994 to 2020, encompasses clinical and hemodynamic parameters, including measured and calculated values such as pulmonary capillary wedge pressure, aortic pulsatility index, and cardiac index. Pulmonary capillary wedge pressure and cardiac index values were used to establish 4 distinct hemodynamic profiles. A pulmonary capillary wedge pressure of ≥15 mm Hg indicated congestion, termed wet, while a cardiac index <2.2 L/min per m2 signified inadequate perfusion, labeled cold. The primary outcome comprised a composite of all-cause death, heart transplantation, or the requirement for mechanical circulatory support. RESULTS: Of 1721 patients with TGA, 242 individuals with available invasive hemodynamic data were included. The median follow-up duration after cardiac catheterization was 11.4 (interquartile range, 7.5-15.9) years, with a mean age of 38.5±10.8 years at the time of cardiac catheterization. Among hemodynamic parameters, an aortic pulsatility index <1.5 emerged as a robust predictor of the primary outcome, with adjusted hazard ratios of 5.90 (95% CI, 3.01-11.62; P<0.001). Among the identified 4 hemodynamic profiles, the cold/wet profile was associated with the highest risk for the primary outcome, with an adjusted hazard ratio of 3.83 (95% CI, 1.63-9.02; P<0.001). CONCLUSIONS: A low aortic pulsatility index (<1.5) and the cold/wet hemodynamic profile are linked with an elevated risk of adverse long-term cardiac outcomes in patients with TGA and systemic right ventricle.
Amsterdam University Medical Center the Netherlands
Children's Hospital of Wisconsin Milwaukee
Children's Hospital Omaha and University of Nebraska Medical Center
Children's National Hospital Washington DC
Colorado University School of Medicine Denver
Department of Medicine Royal Melbourne Hospital Melbourne VIC Australia
Departments of Pediatrics and Medicine School of Medicine Stanford University Palo Alto CA
Division of Cardiology St Paul's Hospital University of British Columbia Vancouver BC Canada
Emory University Hospital Atlanta GA
Erasmus Medical Center Rotterdam the Netherlands
Green Lane Paediatric and Congenital Cardiac Service Auckland City Hospital New Zealand
Hospital Universitario Virgen Del Rocio Sevilla Spain
Institute of Medicine Sahlgrenska Academy University of Gothenburg Sweden
Johns Hopkins University Baltimore MD
Knight Cardiovascular Institute Oregon Health and Science University Portland
Montreal Heart Institute QC Canada
Ochsner Medical Center New Orleans LA
Regina General Hospital SK Canada
University Hospital Motol Prague Czech Republic
University of Alberta Edmonton AB Canada
University of California Los Angeles Medical Center
University of Michigan Medical Center Ann Arbor
University of Missouri Kansas City and Saint Luke's Hospital
University of Sydney and Royal Prince Alfred Hospital NSW Australia
University of Washington Medical Center and Seattle Children's Hospital
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24019050
- 003
- CZ-PrNML
- 005
- 20241024111214.0
- 007
- ta
- 008
- 241015s2024 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1161/CIRCHEARTFAILURE.124.011882 $2 doi
- 035 __
- $a (PubMed)39206568
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Aldweib, Nael $u Knight Cardiovascular Institute, Oregon Health and Science University, Portland (N.A., C.S.B., A.A., L.M., C.M.) $1 https://orcid.org/0000000226805371
- 245 10
- $a Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle / $c N. Aldweib, P. Deghani, CS. Broberg, A. van Dissel, A. Altibi, J. Wong, D. Baker, S. Gindi, P. Khairy, AR. Opotowsky, S. Shah, A. Magalski, J. Cramer, RM. Kauling, M. Dellborg, EV. Krieger, E. Yeung, J. Roos-Hesselink, J. Aboulhosn, J. Nicolarsen, L. Masha, P. Gallego, DS. Celermajer, J. Kay, I. Vonder Muhll, SM. Jameson, C. O'Donnell, F. Fusco, AS. John, C. Macon, P. Antonova, T. Cotts, B. Sarubbi, F. Rodriguez, C. DeZorzi, PS. Jayadeva, M. Kuo, S. Kutty, T. Gupta, LJ. Burchill, CP. Rodriguez Monserrate, AM. Lubert, J. Grewal, S. Pylypchuk, MN. Belkin, WM. Wilson
- 520 9_
- $a BACKGROUND: Patients with transposition of the great arteries (TGA) and systemic right ventricle often confront significant adverse cardiac events. The prognostic significance of invasive hemodynamic parameters in this context remains uncertain. Our hypothesis is that the aortic pulsatility index and hemodynamic profiling utilizing invasive measures provide prognostic insights for patients with TGA and a systemic right ventricle. METHODS: This retrospective multicenter cohort study encompasses adults with TGA and a systemic right ventricle who underwent cardiac catheterization. Data collection, spanning from 1994 to 2020, encompasses clinical and hemodynamic parameters, including measured and calculated values such as pulmonary capillary wedge pressure, aortic pulsatility index, and cardiac index. Pulmonary capillary wedge pressure and cardiac index values were used to establish 4 distinct hemodynamic profiles. A pulmonary capillary wedge pressure of ≥15 mm Hg indicated congestion, termed wet, while a cardiac index <2.2 L/min per m2 signified inadequate perfusion, labeled cold. The primary outcome comprised a composite of all-cause death, heart transplantation, or the requirement for mechanical circulatory support. RESULTS: Of 1721 patients with TGA, 242 individuals with available invasive hemodynamic data were included. The median follow-up duration after cardiac catheterization was 11.4 (interquartile range, 7.5-15.9) years, with a mean age of 38.5±10.8 years at the time of cardiac catheterization. Among hemodynamic parameters, an aortic pulsatility index <1.5 emerged as a robust predictor of the primary outcome, with adjusted hazard ratios of 5.90 (95% CI, 3.01-11.62; P<0.001). Among the identified 4 hemodynamic profiles, the cold/wet profile was associated with the highest risk for the primary outcome, with an adjusted hazard ratio of 3.83 (95% CI, 1.63-9.02; P<0.001). CONCLUSIONS: A low aortic pulsatility index (<1.5) and the cold/wet hemodynamic profile are linked with an elevated risk of adverse long-term cardiac outcomes in patients with TGA and systemic right ventricle.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a transpozice velkých cév $x patofyziologie $x chirurgie $7 D014188
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 12
- $a hemodynamika $x fyziologie $7 D006439
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a prognóza $7 D011379
- 650 12
- $a srdeční katetrizace $7 D006328
- 650 12
- $a srdeční komory $x patofyziologie $x diagnostické zobrazování $7 D006352
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a funkce pravé komory srdeční $x fyziologie $7 D016278
- 650 _2
- $a plicní tlak v zaklínění $x fyziologie $7 D011669
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Deghani, Payam $u Regina General Hospital, SK, Canada (P.D.) $1 https://orcid.org/0000000178587989
- 700 1_
- $a Broberg, Craig S $u Knight Cardiovascular Institute, Oregon Health and Science University, Portland (N.A., C.S.B., A.A., L.M., C.M.) $1 https://orcid.org/0000000297979803
- 700 1_
- $a van Dissel, Alexandra $u Amsterdam University Medical Center, the Netherlands (A.v.D.) $1 https://orcid.org/0000000337300720
- 700 1_
- $a Altibi, Ahmad $u Knight Cardiovascular Institute, Oregon Health and Science University, Portland (N.A., C.S.B., A.A., L.M., C.M.) $1 https://orcid.org/0000000175185415
- 700 1_
- $a Wong, Joshua $u Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia (J.W., P.S.J., L.J.B., W.M.W.)
- 700 1_
- $a Baker, David $u University of Sydney and Royal Prince Alfred Hospital, NSW, Australia (D.B.) $1 https://orcid.org/0000000173497554
- 700 1_
- $a Gindi, Salil $u Children's Hospital of Wisconsin, Milwaukee (S.G.)
- 700 1_
- $a Khairy, Paul $u Montreal Heart Institute, QC, Canada (P.K.) $1 https://orcid.org/0000000340593800
- 700 1_
- $a Opotowsky, Alexander R $u Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Heart Institute, University of Cincinnati College of Medicine, OH (A.R.O., A.M.L.) $1 https://orcid.org/0000000261072281
- 700 1_
- $a Shah, Sangeeta $u Ochsner Medical Center, New Orleans, LA (S.S., M.K., T.G.)
- 700 1_
- $a Magalski, Anthony $u University of Missouri-Kansas City and Saint Luke's Hospital (A.M.)
- 700 1_
- $a Cramer, Jonathan $u Children's Hospital, Omaha and University of Nebraska Medical Center (J.C.)
- 700 1_
- $a Kauling, Robert M $u Erasmus Medical Center, Rotterdam, the Netherlands (R.M.K., J.R.-H.) $1 https://orcid.org/0000000286547634
- 700 1_
- $a Dellborg, Mikael $u Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden (M.D.) $1 https://orcid.org/0000000165028838
- 700 1_
- $a Krieger, Eric V $u University of Washington Medical Center and Seattle Children's Hospital (E.V.K.) $1 https://orcid.org/0000000265255966
- 700 1_
- $a Yeung, Elizabeth $u Colorado University School of Medicine, Denver (E.Y., J.K.) $1 https://orcid.org/0000000244594256
- 700 1_
- $a Roos-Hesselink, Jolien $u Erasmus Medical Center, Rotterdam, the Netherlands (R.M.K., J.R.-H.) $1 https://orcid.org/0000000267703830 $7 ntk20231205347 ntk20231205346
- 700 1_
- $a Aboulhosn, Jamil $u University of California, Los Angeles Medical Center (J.A.) $1 https://orcid.org/0000000202099505
- 700 1_
- $a Nicolarsen, Jeremy $u Providence Spokane, WA (J.N.)
- 700 1_
- $a Masha, Luke $u Knight Cardiovascular Institute, Oregon Health and Science University, Portland (N.A., C.S.B., A.A., L.M., C.M.) $1 https://orcid.org/0000000311428056
- 700 1_
- $a Gallego, Pastora $u Hospital Universitario Virgen Del Rocio, Sevilla, Spain (P.G.) $1 https://orcid.org/0000000321155047
- 700 1_
- $a Celermajer, David S $u University of Sydney and Royal Prince Alfred Hospital, NSW, Australia (D.S.C.) $1 https://orcid.org/0000000176400439
- 700 1_
- $a Kay, Joseph $u Colorado University School of Medicine, Denver (E.Y., J.K.) $1 https://orcid.org/0000000332087270
- 700 1_
- $a Vonder Muhll, Isabelle $u University of Alberta, Edmonton, AB, Canada (I.V.M., S.P.) $1 https://orcid.org/0000000176177185
- 700 1_
- $a Jameson, Susan M $u Departments of Pediatrics and Medicine, School of Medicine, Stanford University, Palo Alto, CA (S.M.J.) $1 https://orcid.org/0000000230626827
- 700 1_
- $a O'Donnell, Clare $u Green Lane Paediatric and Congenital Cardiac Service, Auckland City Hospital, New Zealand (C.O.)
- 700 1_
- $a Fusco, Flavia $u Monaldi Hospital, Napoli, Italy (F.F., B.S.) $1 https://orcid.org/0000000290617834
- 700 1_
- $a John, Anitha S $u Children's National Hospital, Washington, DC (A.S.J.)
- 700 1_
- $a Macon, Conrad $u Knight Cardiovascular Institute, Oregon Health and Science University, Portland (N.A., C.S.B., A.A., L.M., C.M.)
- 700 1_
- $a Antonova, Petra $u University Hospital Motol, Prague, Czech Republic (P.A.) $1 https://orcid.org/0000000332727928
- 700 1_
- $a Cotts, Timothy $u University of Michigan Medical Center, Ann Arbor (T.C.)
- 700 1_
- $a Sarubbi, Berardo $u Monaldi Hospital, Napoli, Italy (F.F., B.S.) $1 https://orcid.org/0000000199418500
- 700 1_
- $a Rodriguez, Fred $u Emory University Hospital, Atlanta, GA (F.R.) $1 https://orcid.org/0000000248333483
- 700 1_
- $a DeZorzi, Christopher $u Department of Pediatrics, Boston Children's Hospital, and Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (C.D., C.P.R.M.)
- 700 1_
- $a Jayadeva, Pavithra S $u Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia (J.W., P.S.J., L.J.B., W.M.W.)
- 700 1_
- $a Kuo, Marissa $u Ochsner Medical Center, New Orleans, LA (S.S., M.K., T.G.) $1 https://orcid.org/0009000948028612
- 700 1_
- $a Kutty, Shelby $u Johns Hopkins University, Baltimore, MD (S.K.)
- 700 1_
- $a Gupta, Tripti $u Ochsner Medical Center, New Orleans, LA (S.S., M.K., T.G.) $1 https://orcid.org/0000000266098632
- 700 1_
- $a Burchill, Luke J $u Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia (J.W., P.S.J., L.J.B., W.M.W.) $1 https://orcid.org/0000000197861840
- 700 1_
- $a Rodriguez Monserrate, Carla P $u Department of Pediatrics, Boston Children's Hospital, and Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (C.D., C.P.R.M.) $1 https://orcid.org/0000000192974416
- 700 1_
- $a Lubert, Adam M $u Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Heart Institute, University of Cincinnati College of Medicine, OH (A.R.O., A.M.L.) $1 https://orcid.org/0000000164019980
- 700 1_
- $a Grewal, Jasmine $u Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada (J.G.)
- 700 1_
- $a Pylypchuk, Stephen $u University of Alberta, Edmonton, AB, Canada (I.V.M., S.P.) $1 https://orcid.org/0000000237652286
- 700 1_
- $a Belkin, Mark N $u University of Chicago, IL (M.N.B.)
- 700 1_
- $a Wilson, William M $u Department of Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia (J.W., P.S.J., L.J.B., W.M.W.)
- 773 0_
- $w MED00159985 $t Circulation. Heart failure $x 1941-3297 $g Roč. 17, č. 9 (2024), s. e011882
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39206568 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20241015 $b ABA008
- 991 __
- $a 20241024111208 $b ABA008
- 999 __
- $a ok $b bmc $g 2201708 $s 1231023
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 17 $c 9 $d e011882 $e 20240829 $i 1941-3297 $m Circulation. Heart failure $n Circ Heart Fail $x MED00159985
- GRA __
- $a 0885045N $p American Heart Association-American Stroke Association $2 United States
- GRA __
- $a UL1 TR002369 $p NCATS NIH HHS $2 United States
- LZP __
- $a Pubmed-20241015
