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Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry
M. Niedoszytko, A. Gorska, K. Brockow, P. Bonadonna, M. Lange, H. Kluin-Nelemans, H. Oude-Elberink, V. Sabato, K. Shoumariyeh, D. von Bubnoff, S. Müller, A. Illerhaus, M. Doubek, I. Angelova-Fischer, O. Hermine, M. Arock, C. Elena, L. Malcovati,...
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články
Grantová podpora
Gdański Uniwersytet Medyczny
Fonds Wetenschappelijk Onderzoek
PubMed
38651829
DOI
10.1111/all.16132
Knihovny.cz E-zdroje
- MeSH
- alergie epidemiologie diagnóza MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mastocytóza * epidemiologie diagnóza komplikace MeSH
- mladiství MeSH
- mladý dospělý MeSH
- pilotní projekty MeSH
- prevalence MeSH
- registrace * MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up. The study group consisted of 2485 adults with mastocytosis, 1379 women (55.5%) and 1106 men (44.5%). Median age was 48.2 years (range 18-91 years). RESULTS: Nine hundred and forty eight patients (38.1%) reported one or more HR`. Most common triggers were Hymenoptera venoms in cutaneous mastocytosis (CM) and indolent systemic mastocytosis (ISM), whereas in advanced SM (advSM), most common elicitors were drugs, including nonsteroidal anti-inflammatory agents and penicillin. In multivariate analyses, tryptase level < 90 ng/mL, <15% infiltration by mast cells in bone marrow biopsy-sections, and diagnosis of ISM were identified as independent risk factors for HR. For drug-induced HR, prominent risk factors were advSM and high tryptase levels. New reactions were observed in 4.8% of all patients during 4 years follow-up. CONCLUSIONS: HR are mainly triggered by Hymenoptera venoms in patients with CM and ISM and by drugs in patients with advSM. Tryptase levels <90 ng/mL, mast cell bone marrow infiltration <15%, and WHO category ISM are predictors of HR. New HR occur in 4.8% of all patients within 4 years.
Allergy Unit Azienda Ospedaliera Universitaria Integrata di Verona Verona Italy
Brno University Hospital Brno Czech Republic
Clinic for Hematology and Oncology Kepler University Hospital Linz Austria
Department of Allergology Medical University of Gdansk Gdansk Poland
Department of Allergology University Medical Center Groningen The Netherlands
Department of Dermatology Kepler University Hospital Linz Austria
Department of Dermatology Venereology and Allergology Medical University of Gdansk Gdansk Poland
Department of Hematology and Oncology Helios Pforzheim Pforzheim Germany
Department of Hematology Fondazione IRCCS Fondazione Policlinico San Matteo Pavia Italy
Department of Medicine Section of Hematology University of Verona Verona Italy
Department of Molecular Medicine University of Pavia Pavia Italy
Department of Public Health and Caring Sciences Uppsala University Uppsala Sweden
Dermatologie Uniklinik Köln Köln Germany
Invicta Fertility and Reproductive Center Molecular Laboratory Sopot Poland
Istanbul University Istanbul Faculty of Medicine Istanbul Türkiye
Ludwig Boltzmann Institute for Hematology and Oncology Medical University of Vienna Vienna Austria
Medical University of Graz Univ Klinik für Dermatologie Graz Austria
Pediatric Dermatology Internal Medicine Azienda Ospedaliera Università di Padova Padova Italy
Semmelweis University Budapest Budapest Hungary
Stanford University School of Medicine Hematology Clinic Stanford USA
Unit of Dermatology and CEREMAST Pitié Salpêtrière Hospital Sorbonne Université Paris France
Universitätsklinikum Leipzig AöR Leipzig Germany
Universitätsmedizin Mannheim 3 Medizinische Klinik Mannhein Germany
Citace poskytuje Crossref.org
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- $a BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up. The study group consisted of 2485 adults with mastocytosis, 1379 women (55.5%) and 1106 men (44.5%). Median age was 48.2 years (range 18-91 years). RESULTS: Nine hundred and forty eight patients (38.1%) reported one or more HR`. Most common triggers were Hymenoptera venoms in cutaneous mastocytosis (CM) and indolent systemic mastocytosis (ISM), whereas in advanced SM (advSM), most common elicitors were drugs, including nonsteroidal anti-inflammatory agents and penicillin. In multivariate analyses, tryptase level < 90 ng/mL, <15% infiltration by mast cells in bone marrow biopsy-sections, and diagnosis of ISM were identified as independent risk factors for HR. For drug-induced HR, prominent risk factors were advSM and high tryptase levels. New reactions were observed in 4.8% of all patients during 4 years follow-up. CONCLUSIONS: HR are mainly triggered by Hymenoptera venoms in patients with CM and ISM and by drugs in patients with advSM. Tryptase levels <90 ng/mL, mast cell bone marrow infiltration <15%, and WHO category ISM are predictors of HR. New HR occur in 4.8% of all patients within 4 years.
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