-
Je něco špatně v tomto záznamu ?
Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement
D. Green, R. van Ewijk, E. Tirtei, D. Andreou, F. Baecklund, D. Baumhoer, SS. Bielack, R. Botchu, K. Boye, B. Brennan, M. Capra, L. Cottone, U. Dirksen, F. Fagioli, N. Fernandez, AM. Flanagan, M. Gambarotti, N. Gaspar, H. Gelderblom, C. Gerrand,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
Grantová podpora
BCRT/8422 and BCRT/7721
Bone Cancer Research Trust (BCRT)
Foerderkreis Krebskranke Kinder eV Stuttgart
DKS 2021.13
German Child Cancer Foundation
NLK
Free Medical Journals
od 1995 do Před 1 rokem
Freely Accessible Science Journals
od 1995
Open Access Digital Library
od 1995-01-01
Open Access Digital Library
od 1995-01-01
- MeSH
- banky biologického materiálu MeSH
- Ewingův sarkom * terapie patologie diagnóza MeSH
- lidé MeSH
- nádorové biomarkery MeSH
- nádory kostí * terapie patologie MeSH
- odběr biologického vzorku * metody normy MeSH
- osteosarkom * terapie patologie diagnóza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Geografické názvy
- Evropa MeSH
Osteosarcoma and Ewing sarcoma are bone tumors mostly diagnosed in children, adolescents, and young adults. Despite multimodal therapy, morbidity is high and survival rates remain low, especially in the metastatic disease setting. Trials investigating targeted therapies and immunotherapies have not been groundbreaking. Better understanding of biological subgroups, the role of the tumor immune microenvironment, factors that promote metastasis, and clinical biomarkers of prognosis and drug response are required to make progress. A prerequisite to achieve desired success is a thorough, systematic, and clinically linked biological analysis of patient samples, but disease rarity and tissue processing challenges such as logistics and infrastructure have contributed to a lack of relevant samples for clinical care and research. There is a need for a Europe-wide framework to be implemented for the adequate and minimal sampling, processing, storage, and analysis of patient samples. Two international panels of scientists, clinicians, and patient and parent advocates have formed the Fight Osteosarcoma Through European Research consortium and the Euro Ewing Consortium. The consortia shared their expertise and institutional practices to formulate new guidelines. We report new reference standards for adequate and minimally required sampling (time points, diagnostic samples, and liquid biopsy tubes), handling, and biobanking to enable advanced biological studies in bone sarcoma. We describe standards for analysis and annotation to drive collaboration and data harmonization with practical, legal, and ethical considerations. This position paper provides comprehensive guidelines that should become the new standards of care that will accelerate scientific progress, promote collaboration, and improve outcomes.
Balgrist University Hospital Faculty of Medicine University of Zurich Zurich Switzerland
Biomedical Research Centre Norwich Medical School University of East Anglia Norwich United Kingdom
Department of Hematology and Oncology A Trousseau Hospital Sorbonne University APHP Paris France
Department of Medical Oncology Institut Bergonié Bordeaux France
Department of Medical Oncology Institut Curie Paris France
Department of Oncology Oslo University Hospital Oslo Norway
Department of Orthopaedic Surgery and Traumatology Ghent University Hospital Belgium
Department of Orthopaedics and Trauma Medical University of Graz Graz Austria
Department of Pathology Institut Universitaire du Cancer de Toulouse Oncopole Toulouse France
Department of Pathology IRCCS Istituto Ortopedico Rizzoli Bologna Italy
Department of Pathology UCL Cancer Institute University College London London United Kingdom
Department of Pediatrics and AYA Oncology Centre Oscar Lambret Lille France
Department of Public Health and Pediatrics University of Turin Turin Italy
Division of Imaging and Oncology University Medical Center Utrecht Utrecht the Netherlands
EQ ONCOSARC CRCT Inserm UT3 ERL CNRS Toulouse France
Haematology Oncology Children's Health Ireland at Crumlin Dublin Ireland
Histopathology The Royal National Orthopaedic Hospital NHS Trust Stanmore United Kingdom
Institute of Hematology and Pediatric Oncology Léon Bérard Center Lyon France
Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland
Laboratory of Experimental Oncology IRCCS Istituto Ortopedico Rizzoli Bologna Italy
Leiden Center for Computational Oncology Leiden University Medical Center Leiden the Netherlands
Medical Oncology Leiden University Medical Center Leiden the Netherlands
Medical Oncology Vall d'Hebron University Hospital Barcelona Spain
Musculoskeletal Radiology Klinikum Rechts der Isar Technical University of Munich Munich Germany
Oncology and Surgical Oncology for Children and Youth Institute of Mother and Child Warsaw Poland
Orthopaedic Oncology Leiden University Medical Centre Leiden the Netherlands
Orthopaedic Oncology The Royal National Orthopaedic Hospital NHS Trust Stanmore United Kingdom
Orthopaedics and Trauma IRCCS Istituto Ortopedico Rizzoli Bologna Italy
Paediatric Haematology and Oncology University Hospital Motol Prague Czech Republic
Pathology Leiden University Medical Center Leiden the Netherlands
Patient and Parent Advocacy Group FOSTER Washington District of Columbia
Pediatric Hematology Oncology Ippokratio General Hospital of Thessaloniki Thessaloniki Greece
Pediatric Oncology Klinikum Kassel Kassel Germany
Pediatric Oncology Regina Margherita Children's Hospital Turin Italy
Pediatric Oncology Unit Karolinska University Hospital Stockholm Sweden
Pediatrics St Anna Children's Hospital Medical University Vienna Vienna Austria
Portuguese Institute of Oncology of Lisbon Lisbon Portugal
Princess Maxima Center for Pediatric Oncology Utrecht the Netherlands
School of Medicine Nantes Université Nantes France
St Anna Children's Cancer Research Institute Vienna Austria
The Christie NHS Foundation Trust Manchester United Kingdom
The Danish Centre for Particle Therapy Aarhus University Hospital Aarhus Denmark
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24019333
- 003
- CZ-PrNML
- 005
- 20241024111449.0
- 007
- ta
- 008
- 241015s2024 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1158/1078-0432.CCR-24-0101 $2 doi
- 035 __
- $a (PubMed)38869831
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Green, Darrell $u Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom $1 https://orcid.org/0000000202173322
- 245 10
- $a Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement / $c D. Green, R. van Ewijk, E. Tirtei, D. Andreou, F. Baecklund, D. Baumhoer, SS. Bielack, R. Botchu, K. Boye, B. Brennan, M. Capra, L. Cottone, U. Dirksen, F. Fagioli, N. Fernandez, AM. Flanagan, M. Gambarotti, N. Gaspar, H. Gelderblom, C. Gerrand, A. Gomez-Mascard, J. Hardes, S. Hecker-Nolting, E. Kabickova, L. Kager, J. Kanerva, LA. Kester, ML. Kuijjer, V. Laurence, C. Lervat, A. Marchais, P. Marec-Berard, C. Mendes, JHM. Merks, B. Ory, E. Palmerini, P. Pantziarka, E. Papakonstantinou, S. Piperno-Neumann, A. Raciborska, EA. Roundhill, V. Rutkauskaite, A. Safwat, K. Scotlandi, EL. Staals, SJ. Strauss, D. Surdez, GML. Sys, MD. Tabone, M. Toulmonde, C. Valverde, MAJ. van de Sande, K. Wörtler, Q. Campbell-Hewson, MG. McCabe, M. Nathrath
- 520 9_
- $a Osteosarcoma and Ewing sarcoma are bone tumors mostly diagnosed in children, adolescents, and young adults. Despite multimodal therapy, morbidity is high and survival rates remain low, especially in the metastatic disease setting. Trials investigating targeted therapies and immunotherapies have not been groundbreaking. Better understanding of biological subgroups, the role of the tumor immune microenvironment, factors that promote metastasis, and clinical biomarkers of prognosis and drug response are required to make progress. A prerequisite to achieve desired success is a thorough, systematic, and clinically linked biological analysis of patient samples, but disease rarity and tissue processing challenges such as logistics and infrastructure have contributed to a lack of relevant samples for clinical care and research. There is a need for a Europe-wide framework to be implemented for the adequate and minimal sampling, processing, storage, and analysis of patient samples. Two international panels of scientists, clinicians, and patient and parent advocates have formed the Fight Osteosarcoma Through European Research consortium and the Euro Ewing Consortium. The consortia shared their expertise and institutional practices to formulate new guidelines. We report new reference standards for adequate and minimally required sampling (time points, diagnostic samples, and liquid biopsy tubes), handling, and biobanking to enable advanced biological studies in bone sarcoma. We describe standards for analysis and annotation to drive collaboration and data harmonization with practical, legal, and ethical considerations. This position paper provides comprehensive guidelines that should become the new standards of care that will accelerate scientific progress, promote collaboration, and improve outcomes.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a osteosarkom $x terapie $x patologie $x diagnóza $7 D012516
- 650 12
- $a Ewingův sarkom $x terapie $x patologie $x diagnóza $7 D012512
- 650 12
- $a nádory kostí $x terapie $x patologie $7 D001859
- 650 12
- $a odběr biologického vzorku $x metody $x normy $7 D013048
- 650 _2
- $a nádorové biomarkery $7 D014408
- 650 _2
- $a banky biologického materiálu $7 D018070
- 651 _2
- $a Evropa $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a van Ewijk, Roelof $u Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands $1 https://orcid.org/0000000303396031
- 700 1_
- $a Tirtei, Elisa $u Pediatric Oncology, Regina Margherita Children's Hospital, Turin, Italy $u Department of Public Health and Pediatrics, University of Turin, Turin, Italy $1 https://orcid.org/0000000341445957
- 700 1_
- $a Andreou, Dimosthenis $u Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria $1 https://orcid.org/0000000250839678
- 700 1_
- $a Baecklund, Fredrik $u Pediatric Oncology Unit, Karolinska University Hospital, Stockholm, Sweden $1 https://orcid.org/0000000313332912
- 700 1_
- $a Baumhoer, Daniel $u Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland $1 https://orcid.org/0000000221377507
- 700 1_
- $a Bielack, Stefan S $u Center for Pediatric, Adolescent and Women's Medicine, Klinikum Stuttgart-Olgahospital, Stuttgart Cancer Centre, Stuttgart, Germany $1 https://orcid.org/0000000321443153
- 700 1_
- $a Botchu, Rajesh $u Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, United Kingdom $1 https://orcid.org/0000000179982980
- 700 1_
- $a Boye, Kjetil $u Department of Oncology, Oslo University Hospital, Oslo, Norway $1 https://orcid.org/0000000255526283
- 700 1_
- $a Brennan, Bernadette $u Paediatric Oncology, Royal Manchester Children's Hospital, Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom $1 https://orcid.org/0009000328058079
- 700 1_
- $a Capra, Michael $u Haematology/Oncology, Children's Health Ireland at Crumlin, Dublin, Ireland $1 https://orcid.org/0000000159821944
- 700 1_
- $a Cottone, Lucia $u Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom $1 https://orcid.org/0000000293974925
- 700 1_
- $a Dirksen, Uta $u Pediatrics III, West German Cancer Center, University Hospital Essen, German Cancer Consortium (DKTK) Site Essen, Cancer Research Center (NCT) Cologne-Essen, University of Duisburg-Essen, Essen, Germany $1 https://orcid.org/0000000254357860
- 700 1_
- $a Fagioli, Franca $u Pediatric Oncology, Regina Margherita Children's Hospital, Turin, Italy $u Department of Public Health and Pediatrics, University of Turin, Turin, Italy $1 https://orcid.org/000000029257900X
- 700 1_
- $a Fernandez, Natalia $u Patient and Parent Advocacy Group, FOSTER, Washington, District of Columbia $1 https://orcid.org/0000000293628280
- 700 1_
- $a Flanagan, Adrienne M $u Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom $u Histopathology, The Royal National Orthopaedic Hospital NHS Trust, Stanmore, United Kingdom $1 https://orcid.org/0000000228321303
- 700 1_
- $a Gambarotti, Marco $u Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy $1 https://orcid.org/0000000280804484
- 700 1_
- $a Gaspar, Nathalie $u Department of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France $u U1015, Université Paris-Saclay, Villejuif, France $1 https://orcid.org/0000000218278903
- 700 1_
- $a Gelderblom, Hans $u Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands $1 https://orcid.org/0000000192708636
- 700 1_
- $a Gerrand, Craig $u Orthopaedic Oncology, The Royal National Orthopaedic Hospital NHS Trust, Stanmore, United Kingdom $1 https://orcid.org/0000000330434507
- 700 1_
- $a Gomez-Mascard, Anne $u Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France $u EQ ONCOSARC, CRCT Inserm/UT3, ERL CNRS, Toulouse, France $1 https://orcid.org/0000000312238393
- 700 1_
- $a Hardes, Jendrik $u Tumour Orthopaedics, University Hospital Essen, German Cancer Consortium (DKTK) Site Essen, Cancer Research Center (NCT) Cologne-Essen, University of Duisburg-Essen, Essen, Germany $1 https://orcid.org/0000000284082255
- 700 1_
- $a Hecker-Nolting, Stefanie $u Center for Pediatric, Adolescent and Women's Medicine, Klinikum Stuttgart-Olgahospital, Stuttgart Cancer Centre, Stuttgart, Germany $1 https://orcid.org/000000021815138X
- 700 1_
- $a Kabickova, Edita $u Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic $1 https://orcid.org/0000000218726630
- 700 1_
- $a Kager, Leo $u Pediatrics, St Anna Children's Hospital, Medical University Vienna, Vienna, Austria $u St Anna Children's Cancer Research Institute, Vienna, Austria $1 https://orcid.org/0000000349546488
- 700 1_
- $a Kanerva, Jukka $u Hematology-Oncology and Stem Cell Transplantation, HUS Helsinki University Hospital, New Children's Hospital, Helsinki, Finland $1 https://orcid.org/0000000258396058
- 700 1_
- $a Kester, Lennart A $u Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands $1 https://orcid.org/0000000282599971
- 700 1_
- $a Kuijjer, Marieke L $u Computational Biology and Systems Medicine Group, Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway $u Pathology, Leiden University Medical Center, Leiden, the Netherlands $u Leiden Center for Computational Oncology, Leiden University Medical Center, Leiden, the Netherlands $1 https://orcid.org/0000000162803130
- 700 1_
- $a Laurence, Valérie $u Department of Medical Oncology, Institut Curie, Paris, France $1 https://orcid.org/0000000343256252
- 700 1_
- $a Lervat, Cyril $u Department of Pediatrics and AYA Oncology, Centre Oscar Lambret, Lille, France $1 https://orcid.org/000000025343086X
- 700 1_
- $a Marchais, Antonin $u Department of Oncology for Child and Adolescent, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France $1 https://orcid.org/0000000309548294
- 700 1_
- $a Marec-Berard, Perrine $u Institute of Hematology and Pediatric Oncology, Léon Bérard Center, Lyon, France $1 https://orcid.org/0000000153155864
- 700 1_
- $a Mendes, Cristina $u Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal $1 https://orcid.org/0009000981311655
- 700 1_
- $a Merks, Johannes H M $u Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands $u Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht, the Netherlands $1 https://orcid.org/0000000176591028
- 700 1_
- $a Ory, Benjamin $u School of Medicine, Nantes Université, Nantes, France $1 https://orcid.org/0000000226227356
- 700 1_
- $a Palmerini, Emanuela $u Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Orthopedico Rizzoli, Bologna, Italy $1 https://orcid.org/0000000334066705
- 700 1_
- $a Pantziarka, Pan $u Patient and Parent Advocacy Group, FOSTER, Washington, District of Columbia $u Anticancer Fund, Meise, Belgium $u The George Pantziarka TP53 Trust, London, United Kingdom $1 https://orcid.org/0000000246767835
- 700 1_
- $a Papakonstantinou, Evgenia $u Pediatric Hematology-Oncology, Ippokratio General Hospital of Thessaloniki, Thessaloniki, Greece $1 https://orcid.org/0000000156207885
- 700 1_
- $a Piperno-Neumann, Sophie $u Department of Pediatrics and AYA Oncology, Centre Oscar Lambret, Lille, France $1 https://orcid.org/0000000199152810
- 700 1_
- $a Raciborska, Anna $u Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, Warsaw, Poland $1 https://orcid.org/0000000326127934
- 700 1_
- $a Roundhill, Elizabeth A $u Children's Cancer Research Group, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom $1 https://orcid.org/0000000205083648
- 700 1_
- $a Rutkauskaite, Vilma $u Center for Pediatric Oncology and Hematology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania $1 https://orcid.org/0009000889979433
- 700 1_
- $a Safwat, Akmal $u The Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark $1 https://orcid.org/0000000260202320
- 700 1_
- $a Scotlandi, Katia $u Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy $1 https://orcid.org/0000000161149499
- 700 1_
- $a Staals, Eric L $u Orthopaedics and Trauma, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy $1 https://orcid.org/0000000181893055
- 700 1_
- $a Strauss, Sandra J $u Department of Oncology, University College London Hospitals NHS Foundation Trust, UCL Cancer Institute, London, United Kingdom $1 https://orcid.org/0000000183280260
- 700 1_
- $a Surdez, Didier $u Balgrist University Hospital, Faculty of Medicine, University of Zurich (UZH), Zurich, Switzerland $1 https://orcid.org/0000000271187859
- 700 1_
- $a Sys, Gwen M L $u Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Belgium $1 https://orcid.org/0000000253087846
- 700 1_
- $a Tabone, Marie-Dominique $u Department of Hematology and Oncology, A. Trousseau Hospital, Sorbonne University, APHP, Paris, France $1 https://orcid.org/0000000294868454
- 700 1_
- $a Toulmonde, Maud $u Department of Medical Oncology, Institut Bergonié, Bordeaux, France $1 https://orcid.org/0000000338969274
- 700 1_
- $a Valverde, Claudia $u Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain $1 https://orcid.org/0000000341078616
- 700 1_
- $a van de Sande, Michiel A J $u Orthopaedic Oncology, Leiden University Medical Centre, Leiden, the Netherlands $1 https://orcid.org/0000000291567656
- 700 1_
- $a Wörtler, Klaus $u Musculoskeletal Radiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany $1 https://orcid.org/0000000201249735
- 700 1_
- $a Campbell-Hewson, Quentin $u Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom $1 https://orcid.org/0000000315096925
- 700 1_
- $a McCabe, Martin G $u Division of Cancer Sciences, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom $u The Christie NHS Foundation Trust, Manchester, United Kingdom $1 https://orcid.org/0000000251380707
- 700 1_
- $a Nathrath, Michaela $u Children's Cancer Research Center, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany $u Pediatric Oncology, Klinikum Kassel, Kassel, Germany $1 https://orcid.org/0000000215841115
- 773 0_
- $w MED00001121 $t Clinical cancer research : an official journal of the American Association for Cancer Research $x 1557-3265 $g Roč. 30, č. 16 (2024), s. 3395-3406
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38869831 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20241015 $b ABA008
- 991 __
- $a 20241024111443 $b ABA008
- 999 __
- $a ok $b bmc $g 2201898 $s 1231306
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 30 $c 16 $d 3395-3406 $e 20240815 $i 1557-3265 $m Clinical cancer research : an official journal of the American Association for Cancer Research $n Clin Cancer Res $x MED00001121
- GRA __
- $a BCRT/8422 and BCRT/7721 $p Bone Cancer Research Trust (BCRT)
- GRA __
- $p Foerderkreis Krebskranke Kinder eV Stuttgart
- GRA __
- $a DKS 2021.13 $p German Child Cancer Foundation
- LZP __
- $a Pubmed-20241015
