-
Je něco špatně v tomto záznamu ?
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands
MA. Krzyscik, K. Karl, P. Dudeja, P. Krejci, K. Hristova
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
Grantová podpora
R01 GM068619
NIGMS NIH HHS - United States
- MeSH
- chondrocyty metabolismus MeSH
- fibroblastové růstové faktory * metabolismus MeSH
- lidé MeSH
- ligandy MeSH
- receptor fibroblastových růstových faktorů, typ 1 * metabolismus MeSH
- receptory fibroblastových růstových faktorů * metabolismus MeSH
- signální transdukce * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.
Department of Biology Faculty of Medicine Masaryk University Brno 62500 Czech Republic
Institute of Animal Physiology and Genetics of the CAS Brno 60200 Czech Republic
International Clinical Research Center St Anne's University Hospital Brno 65691 Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24019458
- 003
- CZ-PrNML
- 005
- 20241024110726.0
- 007
- ta
- 008
- 241015e20240709enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.cytogfr.2024.07.002 $2 doi
- 035 __
- $a (PubMed)39043538
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Krzyscik, Mateusz A $u Department of Materials Science and Engineering and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA
- 245 10
- $a Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands / $c MA. Krzyscik, K. Karl, P. Dudeja, P. Krejci, K. Hristova
- 520 9_
- $a The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.
- 650 12
- $a fibroblastové růstové faktory $x metabolismus $7 D005346
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ligandy $7 D008024
- 650 12
- $a signální transdukce $7 D015398
- 650 12
- $a receptory fibroblastových růstových faktorů $x metabolismus $7 D017468
- 650 12
- $a receptor fibroblastových růstových faktorů, typ 1 $x metabolismus $7 D051496
- 650 _2
- $a chondrocyty $x metabolismus $7 D019902
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Karl, Kelly $u Department of Materials Science and Engineering and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA
- 700 1_
- $a Dudeja, Pooja $u Department of Biology, Faculty of Medicine, Masaryk University, Brno 62500, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno 65691, Czech Republic
- 700 1_
- $a Krejci, Pavel $u Department of Biology, Faculty of Medicine, Masaryk University, Brno 62500, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno 65691, Czech Republic; Institute of Animal Physiology and Genetics of the CAS, Brno 60200, Czech Republic
- 700 1_
- $a Hristova, Kalina $u Department of Materials Science and Engineering and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: kh@jhu.edu
- 773 0_
- $w MED00008700 $t Cytokine & growth factor reviews $x 1879-0305 $g Roč. 78 (20240709), s. 77-84
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39043538 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20241015 $b ABA008
- 991 __
- $a 20241024110720 $b ABA008
- 999 __
- $a ok $b bmc $g 2201976 $s 1231431
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 78 $c - $d 77-84 $e 20240709 $i 1879-0305 $m Cytokine & growth factor reviews $n Cytokine Growth Factor Rev $x MED00008700
- GRA __
- $a R01 GM068619 $p NIGMS NIH HHS $2 United States
- LZP __
- $a Pubmed-20241015