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Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites
Z. Simova, M. Sima, D. Pelclova, P. Klusackova, V. Zdimal, J. Schwarz, L. Maskova, P. Bradna, A. Roubickova, Z. Krejcik, J. Klema, P. Rossner, A. Rossnerova
Nanomedicine (London, England).
2024 ;
19 (17) :
1511-1523.
[pub] 20240702
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc24019747
Grantová podpora
22-08358S
Grantová Agentura České Republiky
Cooperatio: "Dental Medicine" 207031; Pharm
Univerzita Karlova v Praze
- MeSH
- dospělí MeSH
- inhalační expozice * škodlivé účinky MeSH
- lidé MeSH
- messenger RNA genetika MeSH
- mikro RNA * genetika MeSH
- nanočástice chemie MeSH
- nanokompozity * chemie MeSH
- oxidační stres účinky léků MeSH
- pracovní expozice škodlivé účinky MeSH
- transkriptom * účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Aim: Today, there is a lack of research studies concerning human acute exposure to nanoparticles (NPs). Our investigation aimed to simulate real-world acute inhalation exposure to NPs released during work with dental nanocomposites in a dental office or technician laboratory. Methods: Blood samples from female volunteers were processed before and after inhalation exposure. Transcriptomic mRNA and miRNA expression changes were analyzed. Results: We detected large interindividual variability, 90 significantly deregulated mRNAs, and 4 miRNAs when samples of participants before and after dental nanocomposite grinding were compared. Conclusion: The results suggest that inhaled dental NPs may present an occupational hazard to human health, as indicated by the changes in the processes related to oxidative stress, synthesis of eicosanoids, and cell division.
Citace poskytuje Crossref.org
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