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Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites
Z. Simova, M. Sima, D. Pelclova, P. Klusackova, V. Zdimal, J. Schwarz, L. Maskova, P. Bradna, A. Roubickova, Z. Krejcik, J. Klema, P. Rossner, A. Rossnerova
Nanomedicine (London, England).
2024 ;
19 (17) :
1511-1523.
[pub] 20240702
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc24019747
Grant support
22-08358S
Grantová Agentura České Republiky
Cooperatio: "Dental Medicine" 207031; Pharm
Univerzita Karlova v Praze
- MeSH
- Adult MeSH
- Inhalation Exposure * adverse effects MeSH
- Humans MeSH
- RNA, Messenger genetics MeSH
- MicroRNAs * genetics MeSH
- Nanoparticles chemistry MeSH
- Nanocomposites * chemistry MeSH
- Oxidative Stress drug effects MeSH
- Occupational Exposure adverse effects MeSH
- Transcriptome * drug effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Aim: Today, there is a lack of research studies concerning human acute exposure to nanoparticles (NPs). Our investigation aimed to simulate real-world acute inhalation exposure to NPs released during work with dental nanocomposites in a dental office or technician laboratory. Methods: Blood samples from female volunteers were processed before and after inhalation exposure. Transcriptomic mRNA and miRNA expression changes were analyzed. Results: We detected large interindividual variability, 90 significantly deregulated mRNAs, and 4 miRNAs when samples of participants before and after dental nanocomposite grinding were compared. Conclusion: The results suggest that inhaled dental NPs may present an occupational hazard to human health, as indicated by the changes in the processes related to oxidative stress, synthesis of eicosanoids, and cell division.
References provided by Crossref.org
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