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Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
T. Cervantes Rincón, T. Kapoor, JR. Keeffe, L. Simonelli, HH. Hoffmann, M. Agudelo, A. Jurado, A. Peace, YE. Lee, A. Gazumyan, F. Guidetti, J. Cantergiani, B. Cena, F. Bianchini, E. Tamagnini, SG. Moro, P. Svoboda, F. Costa, MG. Reis, AI. Ko, BA....
Language English Country United States
Document type Journal Article
NLK
Cell Press Free Archives
from 2012
Directory of Open Access Journals
from 2012
Free Medical Journals
from 2012
Freely Accessible Science Journals
from 2012-01-26
Open Access Digital Library
from 2012-01-01
Open Access Digital Library
from 2012-01-26
- MeSH
- Epitopes immunology MeSH
- Flavivirus immunology MeSH
- Ticks virology immunology MeSH
- Humans MeSH
- Antibodies, Monoclonal immunology MeSH
- Antibodies, Neutralizing * immunology MeSH
- Antibodies, Viral immunology MeSH
- Encephalitis Viruses, Tick-Borne immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Brazil MeSH
- Mexico MeSH
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.
Department of Epidemiology of Microbial Diseases Yale School of Public Health New Haven CT 06511 USA
Faculty of Medicine of Bahia Federal University of Bahia Salvador 40025 Brazil
Gonçalo Moniz Institute Oswaldo Cruz Foundation Ministry of Health Salvador BA 40296 Brazil
Howard Hughes Medical Institute The Rockefeller University New York NY 10065 USA
Institute for Research in Biomedicine Università della Svizzera italiana 6500 Bellinzona Switzerland
Institute of Collective Health Federal University of Bahia Salvador BA 40025 Brazil
Institute of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic
Laboratory of Molecular Immunology The Rockefeller University New York NY 10065 USA
Laboratory of Virology and Infectious Disease The Rockefeller University New York NY 10065 USA
National Institute of Respiratory Diseases Mexico City CP 14080 Mexico
References provided by Crossref.org
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