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Synthesis and structural confirmation of selaginpulvilin X

T. Havlíková, S. Nallappan, I. Císařová, L. Rycek

. 2024 ; 22 (45) : 8843-8846. [pub] 20241121

Status not-indexed Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25002097

We report the first total synthesis of the natural product selaginpulvilin X, a selaginellaceae polyphenol class of compounds. Our synthetic strategy employs cross-coupling reactions and an organolithium addition to construct the carbon framework. Subsequently, the functional group modifications and deprotection yield the natural product. Spectral analysis confirms the proposed structure by comparing natural and synthetic samples.

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$a Císařová, Ivana $u Department of Inorganic Chemistry, Faculty of Science Charles University Hlavova 8, 128 00 Prague, Czech Republic
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