Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis

R. Abdelnaby, AS. Shabib, MH. El Din Moawad, T. Salem, M. Wagih Youssef Awad, PD. Awad, I. Maallem, H. Atwan, SA. Rabie, KA. Mohamed, H. Abdelmageed, AM. Karkour, M. Elsayed, MS. Cartwright

. 2024 ; 6 (1) : 47. [pub] 20241017

Status neindexováno Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25002340

BACKGROUND/ AIM: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons, causing progressive atrophy of muscles, hypertonia, and paralysis. This study aimed to evaluate the current evidence and effectiveness of ultrasound in investigating nerve cross-sectional area (CSA) of peripheral nerves, vagus and cervical roots in those with ALS compared with healthy controls and to pool the CSA measurements. METHODS: A systematic search was conducted on Cochrane, Clarivate Web of Science, PubMed, Scopus, and Embase for the mesh terms nerve, ultrasonography, and amyotrophic lateral sclerosis. A quality assessment was performed using the New-Ottawa scale. In addition, a double-arm meta-analysis using Review Manager 5 software version 5.4 was performed. RESULTS: From the seventeen studies included in this review, the overall mean difference showed that individuals with ALS had a significantly smaller CSA in comparison to healthy controls for median, ulnar, C6 root, and phrenic nerves. However, no significant difference in the CSA was found in radial, vagal, sural, and tibial nerves. DISCUSSION: This study confirmed results of some of the included studies regards the anatomic sites, where nerve atrophy in ALS could be detected to potentially support the diagnosis of ALS. However, we recommend further large, prospective studies to assess the diagnostic value of these anatomical sites for the diagnosis of ALS. CONCLUSIONS: Our findings confirmed specific anatomic sites to differentiate ALS patients from healthy controls through ultrasound. However, these findings cannot be used to confirm the ALS diagnosis, but rather assist in differentiating it from other diagnoses. TRIAL REGISTRATION: Retrospectively registered on July 30th 2024 in PROSPERO (PROSPERO (york.ac.uk)) with ID574702.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25002340
003      
CZ-PrNML
005      
20250123101840.0
007      
ta
008      
250117s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s42466-024-00346-z $2 doi
035    __
$a (PubMed)39415277
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Abdelnaby, Ramy $u Department of Neurology, RWTH Aachen University, Pauwels Street 30, 52074, Aachen, Germany. rabdelnaby@ukaachen.de $1 https://orcid.org/0000000151612195
245    10
$a Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis / $c R. Abdelnaby, AS. Shabib, MH. El Din Moawad, T. Salem, M. Wagih Youssef Awad, PD. Awad, I. Maallem, H. Atwan, SA. Rabie, KA. Mohamed, H. Abdelmageed, AM. Karkour, M. Elsayed, MS. Cartwright
520    9_
$a BACKGROUND/ AIM: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons, causing progressive atrophy of muscles, hypertonia, and paralysis. This study aimed to evaluate the current evidence and effectiveness of ultrasound in investigating nerve cross-sectional area (CSA) of peripheral nerves, vagus and cervical roots in those with ALS compared with healthy controls and to pool the CSA measurements. METHODS: A systematic search was conducted on Cochrane, Clarivate Web of Science, PubMed, Scopus, and Embase for the mesh terms nerve, ultrasonography, and amyotrophic lateral sclerosis. A quality assessment was performed using the New-Ottawa scale. In addition, a double-arm meta-analysis using Review Manager 5 software version 5.4 was performed. RESULTS: From the seventeen studies included in this review, the overall mean difference showed that individuals with ALS had a significantly smaller CSA in comparison to healthy controls for median, ulnar, C6 root, and phrenic nerves. However, no significant difference in the CSA was found in radial, vagal, sural, and tibial nerves. DISCUSSION: This study confirmed results of some of the included studies regards the anatomic sites, where nerve atrophy in ALS could be detected to potentially support the diagnosis of ALS. However, we recommend further large, prospective studies to assess the diagnostic value of these anatomical sites for the diagnosis of ALS. CONCLUSIONS: Our findings confirmed specific anatomic sites to differentiate ALS patients from healthy controls through ultrasound. However, these findings cannot be used to confirm the ALS diagnosis, but rather assist in differentiating it from other diagnoses. TRIAL REGISTRATION: Retrospectively registered on July 30th 2024 in PROSPERO (PROSPERO (york.ac.uk)) with ID574702.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Shabib, Ahmed Samy $u Faculty of Medicine, Mansoura University, Mansoura, Egypt $1 https://orcid.org/0000000277011707
700    1_
$a El Din Moawad, Mostafa Hossam $u Faculty of Pharmacy Clinical Department, Alexandria University, Alexandria, Egypt $u Faculty of Medicine, Suez Canal University, Ismailia, Egypt
700    1_
$a Salem, Talal $u Faculty of Medicine, Masaryk University, Brno, Czech Republic $1 https://orcid.org/0009000294017323
700    1_
$a Wagih Youssef Awad, Merna $u Faculty of medicine, Alexandria University, Alexandria, Egypt $1 https://orcid.org/0000000244169452
700    1_
$a Awad, Peter Dawoud $u Department of Public Health, Theodor Bilharz Research Institute, Giza, Egypt $1 https://orcid.org/0000000216071589
700    1_
$a Maallem, Imene $u Faculty of pharmacy, University Grenoble Alpes, La tronche, France $1 https://orcid.org/0000000253563005
700    1_
$a Atwan, Hany $u Faculty of Medicine, Assiut University, Assiut, Egypt $1 https://orcid.org/0000000248432393
700    1_
$a Rabie, Salma Adel $u Faculty of Medicine, October 6 University, Giza, Egypt $1 https://orcid.org/0000000269997043
700    1_
$a Mohamed, Khaled Ashraf $u Faculty of medicine, Cairo University, Cairo, Egypt $1 https://orcid.org/0000000201392873
700    1_
$a Abdelmageed, Hossam $u Neurology Department, University of Greifswald, Greifswald, Germany $1 https://orcid.org/0009000132900842
700    1_
$a Karkour, Ali M $u Microbiology Department, Faculty of Science, Tanta University, Tanta, Egypt
700    1_
$a Elsayed, Mohamed $u Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany $u Department of Psychiatry, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
700    1_
$a Cartwright, Michael S $u Department of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
773    0_
$w MED00215992 $t Neurological research and practice $x 2524-3489 $g Roč. 6, č. 1 (2024), s. 47
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39415277 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250117 $b ABA008
991    __
$a 20250123101834 $b ABA008
999    __
$a ok $b bmc $g 2254544 $s 1238343
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2024 $b 6 $c 1 $d 47 $e 20241017 $i 2524-3489 $m Neurological research and practice $n Neurol Res Pract $x MED00215992
LZP    __
$a Pubmed-20250117

Najít záznam

Citační ukazatele

Možnosti archivace