Infectivity, pathogenicity, and genetic characteristics of mammalian gastric Cryptosporidium spp. in domestic ruminants
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18343038
DOI
10.1016/j.vetpar.2008.01.033
PII: S0304-4017(08)00073-3
Knihovny.cz E-zdroje
- MeSH
- Cryptosporidium * genetika patogenita MeSH
- druhová specificita MeSH
- genetická variace * MeSH
- genotyp MeSH
- interakce hostitele a parazita MeSH
- kryptosporidióza parazitologie veterinární MeSH
- krysa rodu Rattus MeSH
- novorozená zvířata MeSH
- počet parazitárních vajíček MeSH
- přežvýkavci parazitologie MeSH
- RNA protozoální analýza MeSH
- RNA ribozomální 18S analýza MeSH
- skot MeSH
- slez parazitologie patologie MeSH
- stadia vývoje MeSH
- žaludeční sliznice parazitologie patologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- RNA protozoální MeSH
- RNA ribozomální 18S MeSH
Farm ruminants were infected experimentally with four mammalian gastric Cryptosporidium, namely Cryptosporidium andersoni LI03 originated from cattle and three isolates of Cryptosporidium muris from brown rat (isolate RN66), Bactrian camel (isolate CB03) and firstly characterized isolate from East African mole rat (isolate TS03). Sequence characterizations of the small-subunit rRNA gene showed that the LI03 isolate was C. andersoni and the other three isolates belonged to C. muris, although the TS03 isolate showed unique sequence variations (one single nucleotide change and four nucleotide insertions). C. andersoni LI03 was infectious for calves only, whereas lambs and kids were susceptible to C. muris CB03. C. muris TS03 and RN66 were not infectious for any farm ruminants. Infection dynamics including prepatent and patent period and infection intensity of the isolates used differed depending on the host species, but no clinical signs of cryptosporidiosis were observed in any of experimentally infected hosts. Cryptosporidium developmental stages were only detected in infected animals in the abomasum region. Histopathological changes were characterized by dilatation and epithelial metaplasia of infected gastric glands with no significant inflammatory responses in the lamina propria.
Citace poskytuje Crossref.org
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